procaine has been researched along with Depression in 24 studies
Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This article is a review and evaluation of the world literature on the systemic use of procaine in the treatment of the aging process and the common chronic diseases of later life." | 3.65 | The systemic use of procaine in the treatment of the elderly: a review. ( Ostfeld, A; Smith, CM; Stotsky, BA, 1977) |
| "1 years committed to a mental hospital for senile or arteriosclerotic psychoses, 11 received 2% procaine hydrochloride according to Aslan's method, for an average of 13 months, 11 for 6 months, and 10 normal saline." | 3.64 | Procaine (novocain) treatment of patients with senile and arteriosclerotic brain disease. ( CAHN, C; DEUTSCH, M; KRAL, VA; MUELLER, H; SOLYOM, L, 1962) |
| " This dosage was doubled to 10 ml per injection during the second six weeks." | 2.64 | Effects of a procaine preparation (Gerovital H3) in hospitalized geriatric patients: a double-blind study. ( Grossman, J; Hotz, M; Kling, R; Plutchik, R; Rubin, L; Siegel, B; Zwerling, I, 1975) |
| " The beginning dosage of medication should be lower than for younger patients, and elderly patients must be monitored carefully for side effects." | 1.25 | Depression in elderly patients. ( Fann, WE; Wheless, JC, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| KRANTZ, A | 1 |
| BACHET, M | 1 |
| MARCHAIS, P | 1 |
| CASELLA, C | 1 |
| MARCHETTI, G | 1 |
| STUDENT, V | 1 |
| VLACH, V | 1 |
| BOLZANI, L | 1 |
| KRAL, VA | 1 |
| CAHN, C | 1 |
| DEUTSCH, M | 1 |
| MUELLER, H | 1 |
| SOLYOM, L | 1 |
| SIUCHNINSKA, H | 2 |
| SCARDIGLI, G | 1 |
| GUIDI, G | 1 |
| Cwynar, S | 1 |
| Napieralska, M | 1 |
| Posel, Z | 1 |
| Wojdyslawska, I | 1 |
| Frydrychowicz, T | 1 |
| Reisberg, B | 1 |
| Ferris, SH | 1 |
| Gershon, S | 2 |
| Jarvik, LF | 2 |
| Milne, JF | 1 |
| Ostfeld, A | 1 |
| Smith, CM | 1 |
| Stotsky, BA | 1 |
| Olsen, EJ | 1 |
| Bank, L | 1 |
| Ban, TA | 1 |
| Zung, WW | 1 |
| Gianturco, D | 1 |
| Pfieffer, E | 1 |
| Kurland, ML | 1 |
| Hayman, M | 1 |
| Kent, S | 1 |
| Zwerling, I | 1 |
| Plutchik, R | 1 |
| Hotz, M | 1 |
| Kling, R | 1 |
| Rubin, L | 1 |
| Grossman, J | 1 |
| Siegel, B | 1 |
| Fann, WE | 1 |
| Wheless, JC | 1 |
| Kline, NS | 1 |
| Sakalis, G | 1 |
| Oh, D | 1 |
| Shopsin, B | 1 |
| Cohen, S | 1 |
| Ditman, KS | 1 |
| MacFarlane, MD | 2 |
| Besbris, H | 1 |
1 review available for procaine and Depression
| Article | Year |
|---|---|
Pharmacotherapy of senile dementia.
Topics: Adult; Age Factors; Aged; Alzheimer Disease; Amphetamine; Antidepressive Agents, Tricyclic; Dementia | 1980 |
6 trials available for procaine and Depression
| Article | Year |
|---|---|
Gerovital-H3: a clinical trial as an antidepressant.
Topics: Aged; Antidepressive Agents; Clinical Trials as Topic; Depression; Double-Blind Method; Female; Huma | 1978 |
Treatment of depression in the aged with gerovital H3: clinical efficacy and neurophysiological effects.
Topics: Aged; Clinical Trials as Topic; Depression; Humans; Imipramine; Middle Aged; Placebos; Procaine; Psy | 1976 |
Effects of a procaine preparation (Gerovital H3) in hospitalized geriatric patients: a double-blind study.
Topics: Aged; Clinical Trials as Topic; Dementia; Depression; Female; Humans; Injections, Intramuscular; Int | 1975 |
Letter: Effect of procaine on ageing.
Topics: Aged; Aging; Clinical Trials as Topic; Depression; Drug Evaluation; Humans; Procaine; United States; | 1973 |
A trial of Gerovital H-3 in depression during senility.
Topics: Aged; Aging; Antidepressive Agents; Arteriosclerosis; Clinical Trials as Topic; Depression; Humans; | 1974 |
Gerovital H3 in the treatment of the depressed aging patient.
Topics: Adult; Aged; Aging; Anxiety; Clinical Trials as Topic; Depression; Drug Evaluation; Female; Humans; | 1974 |
17 other studies available for procaine and Depression
| Article | Year |
|---|---|
[Treatment of depressive states by vagosympathetic infiltrations].
Topics: Depression; Depressive Disorder; Humans; Procaine | 1952 |
[Psychoses treated by pericarotid injections].
Topics: Depression; Depressive Disorder; Mental Disorders; Procaine; Psychosurgery; Psychotic Disorders | 1953 |
[Effects of procaine, procaine amide and quinidine on the excitability and the depression period of the frog heart].
Topics: Depression; Heart; Procainamide; Procaine; Quinidine | 1956 |
[Treatment of depressive states with procaine injections].
Topics: Depression; Depressive Disorder; Humans; Injections; Neurotic Disorders; Procaine | 1957 |
[On the treatment of disease-induced premature aging with a geriatric agent].
Topics: Aged; Aged, 80 and over; Aging, Premature; Ascorbic Acid; Depression; Depressive Disorder; Procaine; | 1962 |
Procaine (novocain) treatment of patients with senile and arteriosclerotic brain disease.
Topics: Aged; Brain Diseases; Dementia; Depression; Female; Hospitals, Psychiatric; Humans; Intracranial Art | 1962 |
[RESULTS OF THE TREATMENT OF DEPRESSIVE STATES WITH GERIOCAINE (H-3), GLUTAMIC ACID AND PREPARATION PLACENTA DURING THE INVOLUTIONAL STAGE].
Topics: Depression; Depressive Disorder; Drug Therapy; Female; Glutamates; Glutamic Acid; Placenta; Pregnanc | 1964 |
[Therapy with Gerovital H3 in the diseases of senescence and of old age].
Topics: Aged; Aged, 80 and over; Arteriosclerosis; Arthritis; Depression; Depressive Disorder; Geriatrics; P | 1962 |
[Usefulness of edan (Polfa) in the treatment of pain syndromes with hypochondriac and depressive traits].
Topics: Aspirin; Depression; Humans; Hypochondriasis; Pain; Procaine | 1966 |
Gerovital-H3--a review of the literature.
Topics: Aged; Aging; Anesthetics, Local; Anticholesteremic Agents; Dementia; Depression; Humans; Hydrogen-Io | 1975 |
The systemic use of procaine in the treatment of the elderly: a review.
Topics: 4-Aminobenzoic Acid; Adult; Affect; Aged; Aging; Arteriosclerosis; Arthritis; Chronic Disease; Demen | 1977 |
The treatment of depressed geriatric patients.
Topics: Age Factors; Aged; Antidepressive Agents, Tricyclic; Biopharmaceutics; Depression; Dihydroergotoxine | 1978 |
A procaine derivative for the treatment of depression in an outpatient population.
Topics: Aged; Ambulatory Care; Depression; Drug Evaluation; Female; Humans; Male; Middle Aged; Placebos; Pro | 1976 |
A look at Gerovital--the "youth" drug.
Topics: Age Factors; Aged; Aging; Animals; Depression; Female; Humans; Male; Mice; Middle Aged; Monoamine Ox | 1976 |
Depression in elderly patients.
Topics: Adaptation, Psychological; Aged; Antidepressive Agents; Chlordiazepoxide; Depression; Electroconvuls | 1975 |
Possible rationale for procaine (Gerovital H3) therapy in geriatrics: inhibition of monoamine oxidase.
Topics: Aged; Aging; Amines; Animals; Biological Assay; Brain; Catecholamines; Depression; Female; Humans; I | 1973 |
Procaine (Gerovital H3) therapy: mechanism of inhibition of monoamine oxidase.
Topics: Aged; Binding, Competitive; Brain; Depression; Humans; Hydrolysis; Iproniazid; Kinetics; Kynurenine; | 1974 |