procaine and Blood Pressure, Low studies

Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.

Research Excerpts

Excerpt	Relevance	Reference
"The purpose of this study was to determine, by continual reassessment, the 90% effective dose (ED90) of phenylephrine for hypotension after combined spinal-epidural anesthesia."	7.81	Determination of the 90% effective dose (ED90) of phenylephrine for hypotension during elective cesarean delivery using a continual reassessment method. ( Diao, M; Huang, Y; Li, H; Lin, X; Liu, H; Ma, Y; Zhou, J, 2015)
"The purpose of this study was to determine, by continual reassessment, the 90% effective dose (ED90) of phenylephrine for hypotension after combined spinal-epidural anesthesia."	3.81	Determination of the 90% effective dose (ED90) of phenylephrine for hypotension during elective cesarean delivery using a continual reassessment method. ( Diao, M; Huang, Y; Li, H; Lin, X; Liu, H; Ma, Y; Zhou, J, 2015)
"The incidence and degree of hypotension, time to establish surgical analgesia, and several other maternal and fetal variables were studied when 2-chloroprocaine, 3 per cent, and bupivacaine, 0."	3.66	Chloroprocaine vs. bupivacaine for lumbar epidural analgesia for elective cesarean section. ( Dewan, DM; Floyd, HM; Grant, WM; James, FM; Rhyne, L; Westmoreland, RT; Wheeler, AS, 1980)
"Chloroprocaine was comparable with plain 0."	2.79	Intrathecal 1% 2-chloroprocaine vs. 0.5% bupivacaine in ambulatory surgery: a prospective, observer-blinded, randomised, controlled trial. ( Camponovo, C; Cristina, D; Fanelli, A; Fanelli, G; Ghisi, D; Leschka, K; Riva, T; Vassiliou, T; Wulf, H, 2014)

Research

Studies (35)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Time to Ambulate

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (77.14)	18.7374
1990's	1 (2.86)	18.2507
2000's	3 (8.57)	29.6817
2010's	4 (11.43)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Camponovo, C	1
Wulf, H	1
Ghisi, D	1
Fanelli, A	1
Riva, T	1
Cristina, D	1
Vassiliou, T	1
Leschka, K	1
Fanelli, G	1
Fukushima, A	1
Chazono, K	1
Hashimoto, Y	1
Iwajima, Y	1
Yamamoto, S	1
Maeda, Y	1
Ohsawa, M	1
Ono, H	1
Liu, H	1
Huang, Y	1
Diao, M	1
Li, H	1
Ma, Y	1
Lin, X	1
Zhou, J	1
Ghafaripour, S	1
Sahmeddini, MA	1
Lahsaee, SM	1
Khosravi, MB	1
Sattari, H	1
Nikeghbalian, S	1
Shokrizadeh, S	1
Malekhosseine, SA	1
MASON, AA	1
PELMORE, JF	1
ASERMAN, D	1
KERR, WJ	1
LAGEN, JB	1
DOCAL, JC	1
ARRIEN ECHEVARRI, A	1
LEWIS, JM	1
REES, GA	1
SLEIGHT, P	1
CAMPBELL, JR	1
LAWSON, DD	1
SANFORD, J	1
BERGMANN, KH	1
LITWIN, J	1
Lee, JS	1
Harding, RE	1
Bjørnestad, E	1
Iversen, OL	1
Raeder, J	1
Fu, RQ	1
Tian, YK	1
Fang, WR	1
Meĭerovich, SI	1
Begara Mesa, D	1
Vilar Rodriguez, MA	1
Anshelevich, IuV	1
Dumesh, SZ	1
Slaĭdyn', AK	1
Sporan, VG	1
Abboud, TK	1
Khoo, SS	1
Miller, F	1
Doan, T	1
Henriksen, EH	1
James, FM	1
Dewan, DM	1
Floyd, HM	1
Wheeler, AS	1
Grant, WM	1
Rhyne, L	1
Westmoreland, RT	1
Conklin, KA	1
van der Wal, C	1
Ku, YH	1
Zhang, T	1
McAllister, CJ	1
Petin, GI	1
Strelets, BM	1
Krasavin, VA	1
MacLachlan, D	1
Forrest, AL	1
Sehhati, G	1
Frey, R	1
Mildner, R	1
Ahlgren, P	1
Praestholm, J	1
Foussard-Blanpin, O	1
Bretaudeau, J	1
Rosner, S	1
Borodianskiĭ, VI	1
Fukunaga, AF	1
Epstein, RM	1
Shnider, SM	1
Bartelheimer, HK	1
Bauditz, W	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Chloroprocaine Versus Bupivacaine Spinal Anesthesia for Cervical Cerclage[NCT02862912]	Phase 4	43 participants (Actual)	Interventional	2016-11-08	Completed
Low Epidural Anesthesia With Chloroprocaine Versus Lidocaine: a Prospective, Randomized, Double-blinded Multi-centre Clinical Trial in China[NCT02287870]	Phase 4	120 participants (Actual)	Interventional	2008-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Time from spinal anesthesia placement to ability to ambulate. (NCT02862912)
Timeframe: 5 hours

Time to Resolution of Motor Block

Intervention	minutes (Median)
Chloroprocaine (CP)	158
Bupivacaine (BUP)	229

"The mean difference between groups in time between the end of spinal injection (t IT) to time for no motor block (t motor), i.e. tIT - T motor. Motor block will be assessed using the Bromage scale:~Bromage Scale I = free movement of the legs and feet = no block II = able to flex knees, with free movement of feet = partial (33%) block III = unable to flex knees, but with free movement of the feet = almost complete (66%) block IV = unable to move legs or feet = complete block (100%)" (NCT02862912)
Timeframe: 3 hours

Time to Void

Intervention	minutes (Median)
Chloroprocaine (CP)	109
Bupivacaine (BUP)	112

Time from spinal anesthesia injection to ability to void spontaneously. (NCT02862912)
Timeframe: 5 hours

Article	Year
Intrathecal 1% 2-chloroprocaine vs. 0.5% bupivacaine in ambulatory surgery: a prospective, observer-blinded, randomised, controlled trial. Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:5 Topics: Abdomen; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, Spinal	2014
Hypotension after reperfusion in liver transplantation: histidine-tryptophan-ketoglutarate versus University of Wisconsin solution. Progress in transplantation (Aliso Viejo, Calif.), 2010, Volume: 20, Issue:3 Topics: Adenosine; Adult; Allopurinol; Blood Gas Analysis; Female; Glucose; Glutathione; Hemodynamics; Human	2010
Similar onset time of 2-chloroprocaine and lidocaine + epinephrine for epidural anesthesia for elective Cesarean section. Acta anaesthesiologica Scandinavica, 2006, Volume: 50, Issue:3 Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Cesarean Section; Double-B	2006
Combined spinal and epidural anaesthesia with chloroprocaine for hysterectomy. Clinical and experimental pharmacology & physiology, 2008, Volume: 35, Issue:1 Topics: Adult; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Dose-Response Relationship, Dru	2008

Article	Year
Oseltamivir produces hypothermic and neuromuscular effects by inhibition of nicotinic acetylcholine receptor functions: comparison to procaine and bupropion. European journal of pharmacology, 2015, Sep-05, Volume: 762 Topics: Animals; Bradycardia; Bupropion; Drug Synergism; Fever; Hypotension; Male; Mice; Muscle Relaxation;	2015
Determination of the 90% effective dose (ED90) of phenylephrine for hypotension during elective cesarean delivery using a continual reassessment method. European journal of obstetrics, gynecology, and reproductive biology, 2015, Volume: 194 Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Apgar	2015
Combined use of hexamethonium bromide and procaine amide in controlled hypotension; a preliminary report. British medical journal, 1953, Jan-31, Volume: 1, Issue:4804 Topics: Cardiovascular Agents; Hexamethonium; Hypotension; Hypotension, Controlled; Muscle Relaxants, Centra	1953
Controlled hypotension in neurosurgery with hexamethonium and procaine amide. British medical journal, 1953, May-02, Volume: 1, Issue:4817 Topics: Cardiovascular Agents; Hexamethonium; Hypotension; Hypotension, Controlled; Muscle Relaxants, Centra	1953
Cardiovascular diseases. American practitioner and digest of treatment, 1953, Volume: 4, Issue:5 Topics: Arrhythmias, Cardiac; Cardiovascular Diseases; Cardiovascular Surgical Procedures; Cardiovascular Sy	1953
[Controlled hypotension with novocaine and pendiomide]. El Dia medico, 1954, Jan-04, Volume: 26, Issue:1 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Autonomic Agents; Hypotension; Hypotension, Control	1954
[Intravenous novocaine and induced arterial hypotension]. Revista espanola de anestesiologia, 1957, Volume: 4, Issue:1 Topics: Hypotension; Hypotension, Controlled; Procaine	1957
ELECTROCARDIOGRAPHY DURING POSTERIOR FOSSA OPERATIONS. British journal of anaesthesia, 1964, Volume: 36 Topics: Arrhythmias, Cardiac; Electrocardiography; Embolism; Embolism, Air; Humans; Hypotension; Infant; Lid	1964
A CARDIOVASCULAR DEPRESSOR REFLEX FROM THE EPICARDIUM OF THE LEFT VENTRICLE IN THE DOG. The Journal of physiology, 1964, Volume: 173 Topics: Alkaloids; Atropine; Blood Pressure; Bradycardia; Cold Temperature; Coronary Vessels; Dogs; Heart; H	1964
INVESTIGATION OF RESPIRATORY AND CIRCULATORY EFFECTS OF ETHAMIVAN IN THE DOG AND CAT. British journal of anaesthesia, 1964, Volume: 36 Topics: Amines; Aorta; Apnea; Atropine; Benzamides; Blood Pressure; Bradycardia; Carotid Arteries; Cats; Cen	1964
[ON THE QUESTION OF A BLOOD-SPARING OPERATION METHOD IN THE VAGINALPERINEAL AREA]. Zentralblatt fur Gynakologie, 1964, Sep-19, Volume: 86 Topics: Anesthesia; Anesthesia, Local; Anesthesiology; Female; Humans; Hypotension; Hypotension, Controlled;	1964
[Effect of adrenaline administered after adrenolytic drug on hypotensive action of autohemolysates in cats]. Acta physiologica Polonica, 1954, Volume: 5, Issue:4 Topics: Adrenergic Antagonists; Animals; Blood Pressure; Blood Pressure Determination; Cats; Epinephrine; He	1954
Spinal anesthesia in severe preeclampsia. Anesthesia and analgesia, 2004, Volume: 98, Issue:6 Topics: Anesthesia, Spinal; Female; Humans; Hypotension; Pre-Eclampsia; Pregnancy; Procaine	2004
[Experience in the treatment of trigeminal neuralgia with aminazine]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1966, Volume: 66, Issue:6 Topics: Adult; Aged; Analgesics; Chlorpromazine; Female; Humans; Hypotension; Injections, Intramuscular; Mal	1966
[Complications after intravenous administration of anti-arrhythmia agents]. Kardiologiia, 1982, Volume: 22, Issue:11 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Ad	1982
Maternal, fetal, and neonatal responses after epidural anesthesia with bupivacaine, 2-chloroprocaine, or lidocaine. Anesthesia and analgesia, 1982, Volume: 61, Issue:8 Topics: Adolescent; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Behavior; Bupi	1982
Chloroprocaine vs. bupivacaine for lumbar epidural analgesia for elective cesarean section. Anesthesiology, 1980, Volume: 52, Issue:6 Topics: Analgesia; Anesthesia, Epidural; Apgar Score; Blood Gas Analysis; Bupivacaine; Cesarean Section; Eph	1980
Epidural anaesthesia with chloroprocaine. Delayed onset, extensive spread, and prolonged duration. Anaesthesia, 1980, Volume: 35, Issue:2 Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Female; Humans; Hypotension; Pregnancy; Procai	1980
Brain atriopeptin mediates AV3V depressor response. Peptides, 1994, Volume: 15, Issue:6 Topics: Animals; Atrial Natriuretic Factor; Atropine Derivatives; Blood Pressure; Cerebral Ventricles; Drug	1994
Adverse reactions to commonly prescribed drugs in patients with renal insufficiency. Journal of the Tennessee Medical Association, 1977, Volume: 70, Issue:8 Topics: Analgesics; Anti-Bacterial Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Drug-Related Side	1977
[Suppression of cardiac activity and respiration during conduction anesthesia]. Vestnik khirurgii imeni I. I. Grekova, 1989, Volume: 142, Issue:5 Topics: Anesthesia, Conduction; Arteriosclerosis Obliterans; Humans; Hypotension; Leg; Lidocaine; Male; Midd	1989
Letter: Procaine and malignant hyperthermia. Lancet (London, England), 1974, Mar-02, Volume: 1, Issue:7853 Topics: Dose-Response Relationship, Drug; Female; Humans; Hypotension; Injections, Intravenous; Malignant Hy	1974
[Complications of regional anaesthesia and their treatment (author's transl)]. Munchener medizinische Wochenschrift (1950), 1973, Oct-12, Volume: 115, Issue:41 Topics: Adrenal Cortex Hormones; Anesthesia, Local; Apnea; Barbiturates; Bradycardia; Bupivacaine; Diagnosis	1973
[Complications of myelography with methiodal]. Nordisk medicin, 1969, Dec-18, Volume: 82, Issue:51 Topics: Adult; Anesthesia, Spinal; Blood Pressure; Female; Headache; Humans; Hypotension; Male; Mesylates; M	1969
[Study of the mechanism of hypotension induced in certain conditions by epsilon-aminocaproic acid]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1966, Volume: 160, Issue:3 Topics: Aminocaproates; Animals; Atropine; Dogs; Ethanolamines; Hypotension; Phenylbutazone; Procaine; Prome	1966
The diagnosis and treatment of cerebral concussion. International surgery, 1967, Volume: 47, Issue:4 Topics: Ascorbic Acid; Aspirin; Brain Concussion; Cerebral Ventriculography; Cortisone; Diphenhydramine; Ele	1967
[The therapy and prevention of acute renal insufficiency in traumatic shock]. Vestnik khirurgii imeni I. I. Grekova, 1966, Volume: 97, Issue:7 Topics: Acute Kidney Injury; Adult; Autonomic Nerve Block; Diuresis; Female; Histamine H1 Antagonists; Human	1966
Effects of cyclopropane on the sympathetic nervous system and on neural regulation of circulation in the cat. Anesthesiology, 1974, Volume: 40, Issue:4 Topics: Action Potentials; Animals; Aorta; Arrhythmias, Cardiac; Blood; Blood Circulation; Blood Pressure; B	1974
New and interesting aspects of obstetric conduction anesthesia. A. Placental transfer of local anesthetics. Acta anaesthesiologica Scandinavica. Supplementum, 1966, Volume: 25 Topics: Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Animals; Fe	1966
[Treatment of imipramine poisoning at childhood]. Monatsschrift fur Kinderheilkunde, 1970, Volume: 118, Issue:11 Topics: Arrhythmias, Cardiac; Carbon; Child, Preschool; Chloral Hydrate; Coma; Gastric Lavage; Humans; Hypot	1970

procaine and Blood Pressure, Low