Page last updated: 2024-11-03

procaine and Blood Pressure, Low

procaine has been researched along with Blood Pressure, Low in 35 studies

Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.

Research Excerpts

ExcerptRelevanceReference
"The purpose of this study was to determine, by continual reassessment, the 90% effective dose (ED90) of phenylephrine for hypotension after combined spinal-epidural anesthesia."7.81Determination of the 90% effective dose (ED90) of phenylephrine for hypotension during elective cesarean delivery using a continual reassessment method. ( Diao, M; Huang, Y; Li, H; Lin, X; Liu, H; Ma, Y; Zhou, J, 2015)
"The purpose of this study was to determine, by continual reassessment, the 90% effective dose (ED90) of phenylephrine for hypotension after combined spinal-epidural anesthesia."3.81Determination of the 90% effective dose (ED90) of phenylephrine for hypotension during elective cesarean delivery using a continual reassessment method. ( Diao, M; Huang, Y; Li, H; Lin, X; Liu, H; Ma, Y; Zhou, J, 2015)
"The incidence and degree of hypotension, time to establish surgical analgesia, and several other maternal and fetal variables were studied when 2-chloroprocaine, 3 per cent, and bupivacaine, 0."3.66Chloroprocaine vs. bupivacaine for lumbar epidural analgesia for elective cesarean section. ( Dewan, DM; Floyd, HM; Grant, WM; James, FM; Rhyne, L; Westmoreland, RT; Wheeler, AS, 1980)
"Chloroprocaine was comparable with plain 0."2.79Intrathecal 1% 2-chloroprocaine vs. 0.5% bupivacaine in ambulatory surgery: a prospective, observer-blinded, randomised, controlled trial. ( Camponovo, C; Cristina, D; Fanelli, A; Fanelli, G; Ghisi, D; Leschka, K; Riva, T; Vassiliou, T; Wulf, H, 2014)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199027 (77.14)18.7374
1990's1 (2.86)18.2507
2000's3 (8.57)29.6817
2010's4 (11.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Camponovo, C1
Wulf, H1
Ghisi, D1
Fanelli, A1
Riva, T1
Cristina, D1
Vassiliou, T1
Leschka, K1
Fanelli, G1
Fukushima, A1
Chazono, K1
Hashimoto, Y1
Iwajima, Y1
Yamamoto, S1
Maeda, Y1
Ohsawa, M1
Ono, H1
Liu, H1
Huang, Y1
Diao, M1
Li, H1
Ma, Y1
Lin, X1
Zhou, J1
Ghafaripour, S1
Sahmeddini, MA1
Lahsaee, SM1
Khosravi, MB1
Sattari, H1
Nikeghbalian, S1
Shokrizadeh, S1
Malekhosseine, SA1
MASON, AA1
PELMORE, JF1
ASERMAN, D1
KERR, WJ1
LAGEN, JB1
DOCAL, JC1
ARRIEN ECHEVARRI, A1
LEWIS, JM1
REES, GA1
SLEIGHT, P1
CAMPBELL, JR1
LAWSON, DD1
SANFORD, J1
BERGMANN, KH1
LITWIN, J1
Lee, JS1
Harding, RE1
Bjørnestad, E1
Iversen, OL1
Raeder, J1
Fu, RQ1
Tian, YK1
Fang, WR1
Meĭerovich, SI1
Begara Mesa, D1
Vilar Rodriguez, MA1
Anshelevich, IuV1
Dumesh, SZ1
Slaĭdyn', AK1
Sporan, VG1
Abboud, TK1
Khoo, SS1
Miller, F1
Doan, T1
Henriksen, EH1
James, FM1
Dewan, DM1
Floyd, HM1
Wheeler, AS1
Grant, WM1
Rhyne, L1
Westmoreland, RT1
Conklin, KA1
van der Wal, C1
Ku, YH1
Zhang, T1
McAllister, CJ1
Petin, GI1
Strelets, BM1
Krasavin, VA1
MacLachlan, D1
Forrest, AL1
Sehhati, G1
Frey, R1
Mildner, R1
Ahlgren, P1
Praestholm, J1
Foussard-Blanpin, O1
Bretaudeau, J1
Rosner, S1
Borodianskiĭ, VI1
Fukunaga, AF1
Epstein, RM1
Shnider, SM1
Bartelheimer, HK1
Bauditz, W1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Chloroprocaine Versus Bupivacaine Spinal Anesthesia for Cervical Cerclage[NCT02862912]Phase 443 participants (Actual)Interventional2016-11-08Completed
Low Epidural Anesthesia With Chloroprocaine Versus Lidocaine: a Prospective, Randomized, Double-blinded Multi-centre Clinical Trial in China[NCT02287870]Phase 4120 participants (Actual)Interventional2008-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Time to Ambulate

Time from spinal anesthesia placement to ability to ambulate. (NCT02862912)
Timeframe: 5 hours

Interventionminutes (Median)
Chloroprocaine (CP)158
Bupivacaine (BUP)229

Time to Resolution of Motor Block

"The mean difference between groups in time between the end of spinal injection (t IT) to time for no motor block (t motor), i.e. tIT - T motor. Motor block will be assessed using the Bromage scale:~Bromage Scale I = free movement of the legs and feet = no block II = able to flex knees, with free movement of feet = partial (33%) block III = unable to flex knees, but with free movement of the feet = almost complete (66%) block IV = unable to move legs or feet = complete block (100%)" (NCT02862912)
Timeframe: 3 hours

Interventionminutes (Median)
Chloroprocaine (CP)109
Bupivacaine (BUP)112

Time to Void

Time from spinal anesthesia injection to ability to void spontaneously. (NCT02862912)
Timeframe: 5 hours

Interventionminutes (Median)
Bupivacaine (BUP)229
Chloroprocaine (CP)158

Reviews

1 review available for procaine and Blood Pressure, Low

ArticleYear
[Extradural anesthesia in cesarean operations].
    Revista espanola de anestesiologia y reanimacion, 1982, Volume: 29, Issue:4

    Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Bupivacaine; Cesarean Section; Ep

1982

Trials

4 trials available for procaine and Blood Pressure, Low

ArticleYear
Intrathecal 1% 2-chloroprocaine vs. 0.5% bupivacaine in ambulatory surgery: a prospective, observer-blinded, randomised, controlled trial.
    Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:5

    Topics: Abdomen; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, Spinal

2014
Hypotension after reperfusion in liver transplantation: histidine-tryptophan-ketoglutarate versus University of Wisconsin solution.
    Progress in transplantation (Aliso Viejo, Calif.), 2010, Volume: 20, Issue:3

    Topics: Adenosine; Adult; Allopurinol; Blood Gas Analysis; Female; Glucose; Glutathione; Hemodynamics; Human

2010
Similar onset time of 2-chloroprocaine and lidocaine + epinephrine for epidural anesthesia for elective Cesarean section.
    Acta anaesthesiologica Scandinavica, 2006, Volume: 50, Issue:3

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Cesarean Section; Double-B

2006
Combined spinal and epidural anaesthesia with chloroprocaine for hysterectomy.
    Clinical and experimental pharmacology & physiology, 2008, Volume: 35, Issue:1

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Dose-Response Relationship, Dru

2008

Other Studies

30 other studies available for procaine and Blood Pressure, Low

ArticleYear
Oseltamivir produces hypothermic and neuromuscular effects by inhibition of nicotinic acetylcholine receptor functions: comparison to procaine and bupropion.
    European journal of pharmacology, 2015, Sep-05, Volume: 762

    Topics: Animals; Bradycardia; Bupropion; Drug Synergism; Fever; Hypotension; Male; Mice; Muscle Relaxation;

2015
Determination of the 90% effective dose (ED90) of phenylephrine for hypotension during elective cesarean delivery using a continual reassessment method.
    European journal of obstetrics, gynecology, and reproductive biology, 2015, Volume: 194

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Apgar

2015
Combined use of hexamethonium bromide and procaine amide in controlled hypotension; a preliminary report.
    British medical journal, 1953, Jan-31, Volume: 1, Issue:4804

    Topics: Cardiovascular Agents; Hexamethonium; Hypotension; Hypotension, Controlled; Muscle Relaxants, Centra

1953
Controlled hypotension in neurosurgery with hexamethonium and procaine amide.
    British medical journal, 1953, May-02, Volume: 1, Issue:4817

    Topics: Cardiovascular Agents; Hexamethonium; Hypotension; Hypotension, Controlled; Muscle Relaxants, Centra

1953
Cardiovascular diseases.
    American practitioner and digest of treatment, 1953, Volume: 4, Issue:5

    Topics: Arrhythmias, Cardiac; Cardiovascular Diseases; Cardiovascular Surgical Procedures; Cardiovascular Sy

1953
[Controlled hypotension with novocaine and pendiomide].
    El Dia medico, 1954, Jan-04, Volume: 26, Issue:1

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Autonomic Agents; Hypotension; Hypotension, Control

1954
[Intravenous novocaine and induced arterial hypotension].
    Revista espanola de anestesiologia, 1957, Volume: 4, Issue:1

    Topics: Hypotension; Hypotension, Controlled; Procaine

1957
ELECTROCARDIOGRAPHY DURING POSTERIOR FOSSA OPERATIONS.
    British journal of anaesthesia, 1964, Volume: 36

    Topics: Arrhythmias, Cardiac; Electrocardiography; Embolism; Embolism, Air; Humans; Hypotension; Infant; Lid

1964
A CARDIOVASCULAR DEPRESSOR REFLEX FROM THE EPICARDIUM OF THE LEFT VENTRICLE IN THE DOG.
    The Journal of physiology, 1964, Volume: 173

    Topics: Alkaloids; Atropine; Blood Pressure; Bradycardia; Cold Temperature; Coronary Vessels; Dogs; Heart; H

1964
INVESTIGATION OF RESPIRATORY AND CIRCULATORY EFFECTS OF ETHAMIVAN IN THE DOG AND CAT.
    British journal of anaesthesia, 1964, Volume: 36

    Topics: Amines; Aorta; Apnea; Atropine; Benzamides; Blood Pressure; Bradycardia; Carotid Arteries; Cats; Cen

1964
[ON THE QUESTION OF A BLOOD-SPARING OPERATION METHOD IN THE VAGINALPERINEAL AREA].
    Zentralblatt fur Gynakologie, 1964, Sep-19, Volume: 86

    Topics: Anesthesia; Anesthesia, Local; Anesthesiology; Female; Humans; Hypotension; Hypotension, Controlled;

1964
[Effect of adrenaline administered after adrenolytic drug on hypotensive action of autohemolysates in cats].
    Acta physiologica Polonica, 1954, Volume: 5, Issue:4

    Topics: Adrenergic Antagonists; Animals; Blood Pressure; Blood Pressure Determination; Cats; Epinephrine; He

1954
Spinal anesthesia in severe preeclampsia.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:6

    Topics: Anesthesia, Spinal; Female; Humans; Hypotension; Pre-Eclampsia; Pregnancy; Procaine

2004
[Experience in the treatment of trigeminal neuralgia with aminazine].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1966, Volume: 66, Issue:6

    Topics: Adult; Aged; Analgesics; Chlorpromazine; Female; Humans; Hypotension; Injections, Intramuscular; Mal

1966
[Complications after intravenous administration of anti-arrhythmia agents].
    Kardiologiia, 1982, Volume: 22, Issue:11

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Ad

1982
Maternal, fetal, and neonatal responses after epidural anesthesia with bupivacaine, 2-chloroprocaine, or lidocaine.
    Anesthesia and analgesia, 1982, Volume: 61, Issue:8

    Topics: Adolescent; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Behavior; Bupi

1982
Chloroprocaine vs. bupivacaine for lumbar epidural analgesia for elective cesarean section.
    Anesthesiology, 1980, Volume: 52, Issue:6

    Topics: Analgesia; Anesthesia, Epidural; Apgar Score; Blood Gas Analysis; Bupivacaine; Cesarean Section; Eph

1980
Epidural anaesthesia with chloroprocaine. Delayed onset, extensive spread, and prolonged duration.
    Anaesthesia, 1980, Volume: 35, Issue:2

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Female; Humans; Hypotension; Pregnancy; Procai

1980
Brain atriopeptin mediates AV3V depressor response.
    Peptides, 1994, Volume: 15, Issue:6

    Topics: Animals; Atrial Natriuretic Factor; Atropine Derivatives; Blood Pressure; Cerebral Ventricles; Drug

1994
Adverse reactions to commonly prescribed drugs in patients with renal insufficiency.
    Journal of the Tennessee Medical Association, 1977, Volume: 70, Issue:8

    Topics: Analgesics; Anti-Bacterial Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Drug-Related Side

1977
[Suppression of cardiac activity and respiration during conduction anesthesia].
    Vestnik khirurgii imeni I. I. Grekova, 1989, Volume: 142, Issue:5

    Topics: Anesthesia, Conduction; Arteriosclerosis Obliterans; Humans; Hypotension; Leg; Lidocaine; Male; Midd

1989
Letter: Procaine and malignant hyperthermia.
    Lancet (London, England), 1974, Mar-02, Volume: 1, Issue:7853

    Topics: Dose-Response Relationship, Drug; Female; Humans; Hypotension; Injections, Intravenous; Malignant Hy

1974
[Complications of regional anaesthesia and their treatment (author's transl)].
    Munchener medizinische Wochenschrift (1950), 1973, Oct-12, Volume: 115, Issue:41

    Topics: Adrenal Cortex Hormones; Anesthesia, Local; Apnea; Barbiturates; Bradycardia; Bupivacaine; Diagnosis

1973
[Complications of myelography with methiodal].
    Nordisk medicin, 1969, Dec-18, Volume: 82, Issue:51

    Topics: Adult; Anesthesia, Spinal; Blood Pressure; Female; Headache; Humans; Hypotension; Male; Mesylates; M

1969
[Study of the mechanism of hypotension induced in certain conditions by epsilon-aminocaproic acid].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1966, Volume: 160, Issue:3

    Topics: Aminocaproates; Animals; Atropine; Dogs; Ethanolamines; Hypotension; Phenylbutazone; Procaine; Prome

1966
The diagnosis and treatment of cerebral concussion.
    International surgery, 1967, Volume: 47, Issue:4

    Topics: Ascorbic Acid; Aspirin; Brain Concussion; Cerebral Ventriculography; Cortisone; Diphenhydramine; Ele

1967
[The therapy and prevention of acute renal insufficiency in traumatic shock].
    Vestnik khirurgii imeni I. I. Grekova, 1966, Volume: 97, Issue:7

    Topics: Acute Kidney Injury; Adult; Autonomic Nerve Block; Diuresis; Female; Histamine H1 Antagonists; Human

1966
Effects of cyclopropane on the sympathetic nervous system and on neural regulation of circulation in the cat.
    Anesthesiology, 1974, Volume: 40, Issue:4

    Topics: Action Potentials; Animals; Aorta; Arrhythmias, Cardiac; Blood; Blood Circulation; Blood Pressure; B

1974
New and interesting aspects of obstetric conduction anesthesia. A. Placental transfer of local anesthetics.
    Acta anaesthesiologica Scandinavica. Supplementum, 1966, Volume: 25

    Topics: Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Animals; Fe

1966
[Treatment of imipramine poisoning at childhood].
    Monatsschrift fur Kinderheilkunde, 1970, Volume: 118, Issue:11

    Topics: Arrhythmias, Cardiac; Carbon; Child, Preschool; Chloral Hydrate; Coma; Gastric Lavage; Humans; Hypot

1970