Page last updated: 2024-11-03

procaine and Apnea

procaine has been researched along with Apnea in 15 studies

Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.

Apnea: A transient absence of spontaneous respiration.

Research Excerpts

ExcerptRelevanceReference
" Because of these reports, 23 patients with prolonged apnea after administration of succinylcholine were studied with Kalow's method for abnormal dibucaine number (DN), which characterizes this condition, and for the history of local anesthetic toxicity."3.65Survey of local anesthetic toxicity in the families of patients with atypical plasma cholinesterase. ( Eilderton, TE; Zsigmond, EK, 1975)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-199015 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
HAZARD, R1
CHEYMOL, J1
QUINQUAND, A1
IRWIN, RL1
STONE, JE1
DRAPER, WB1
WHITEHEAD, RW1
CAMPBELL, JR1
LAWSON, DD1
SANFORD, J1
BERNSTEIN, EF1
Cozine, RA1
Ngai, SH1
Moore, DC1
Lanks, KW1
Sklar, GS1
Geshelin, SA1
Zsigmond, EK2
Eilderton, TE2
Sehhati, G1
Frey, R1
Mildner, R1
Heissen, E1
Teske, HJ1
Haller, J1
Katz, RL1
Gissen, AJ1
Borison, HL1
Haranath, PS1
McCarthy, LE1
Schläfke, ME1
See, WR1
Massion, WH1
Loeschcke, HH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Intravenous Infusion of Magnesium Sulfate Associated or Not to Lidocaine On the Neuromuscular Blockade Induced by Muscle Relaxant Cistracurium[NCT02483611]Phase 448 participants (Actual)Interventional2015-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Clinical Duration

"The clinical duration is the elapsed time for T1 recovery = 25% (Dur25%) of the original value of T1 after the infusion of cisatracurium.~This outcome meansure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes

Interventionminutes (Median)
Group M82.68
Group ML86.33
Group C64.8

Final Recovery Index

"The final recovery index is the elapsed time between the T1 recovery = 25% (Dur25%) and T4 / T1 = 80% (TOF = 80%) after the infusion of cisatracurium.~This outcome measure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes

Interventionminutes (Mean)
Group M27.97
Group ML33.81
Group C21.51

HR - M1 (Heart Rate in the Moment 1)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The measure of heart rate was recorded and annotated at various times such as in the arrival of the patient in the operating room. This time point was named as moment '1'. (NCT02483611)
Timeframe: This measure of heart rate was performed when the patient arrived in the operating room

Interventionbeats/min (Mean)
Group M79.94
Group ML77.25
Group C73.66

HR - M2 (Heart Rate in the Moment 2)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as in the moment immediately before the anesthesia induction. This time point was named as moment '2'. (NCT02483611)
Timeframe: This measure of heart rate was performed immediately before induction of anesthesia

Interventionbeats/min (Mean)
Group M74.69
Group ML73.69
Group C75.40

HR - M3 (Heart Rate in the Moment 3)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution). This time point was named as moment '3'. (NCT02483611)
Timeframe: This measure of heart rate was performed immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution)

Interventionbeats/min (Mean)
Group M72.94
Group ML74.19
Group C75.40

HR - M4 (Heart Rate in the Moment 4)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as in the end of the study solutions infusion. This time point was named as moment '4'. (NCT02483611)
Timeframe: This measure of heart rate was performed five minutes after M3 (in the end of the X and Y solutions infusion)

Interventionbeats/min (Mean)
Group M71.94
Group ML72.25
Group C65.07

HR - M5 (Heart Rate in the Moment 5)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as immediately before the tracheal intubation. This time point was named as moment '5'. (NCT02483611)
Timeframe: This measure of heart rate was performed immediately before the tracheal intubation

Interventionbeats/min (Mean)
Group M67.56
Group ML69.31
Group C64.27

HR - M6 (Heart Rate in the Moment 6)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as one minute after the tracheal intubation. This time point was named as moment '6'. (NCT02483611)
Timeframe: This measure of heart rate was performed one minute after the tracheal intubation

Interventionbeats/min (Mean)
Group M66.50
Group ML68.19
Group C65.13

HR - M7a (Heart Rate in the Moment 7a)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 15 minutes after the traqueal intubation.This time point was named as moment '7a'. (NCT02483611)
Timeframe: This measure of heart rate was performed 15 minutes after the traqueal intubation

Interventionbeats/min (Mean)
Group M68.94
Group ML68.19
Group C67.13

HR - M7b (Heart Rate in the Moment 7b)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 30 minutes after the traqueal intubation. This time point was named as moment '7b'. (NCT02483611)
Timeframe: This measure of heart rate was performed 30 minutes after the traqueal intubation

Interventionbeats/min (Mean)
Group M67.44
Group ML68.38
Group C64.00

HR - M7c (Heart Rate in the Moment 7c)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 45 minutes after the traqueal intubation. This time point was named as moment '7c'. (NCT02483611)
Timeframe: This measure of heart rate was performed 45 minutes after the traqueal intubation

Interventionbeats/min (Mean)
Group M65.75
Group ML65.75
Group C62.33

HR - M7d (Heart Rate in the Moment 7d)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 60 minutes after the traqueal intubation. This time point was named as moment '7d'. (NCT02483611)
Timeframe: This measure of heart rate was performed 60 minutes after the traqueal intubation

Interventionbeats/min (Mean)
Group M66.19
Group ML65.31
Group C61.93

HR - M7e (Heart Rate in the Moment 7e)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 75 minutes after the traqueal intubation. This time point was named as moment '7e'. (NCT02483611)
Timeframe: This measure of heart rate was performed 75 minutes after the traqueal intubation

Interventionbeats/min (Median)
Group M66.50
Group ML63.00
Group C58.00

HR - M7f (Heart Rate in the Moment 7f)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 90 minutes after the traqueal intubation. This time point was named as moment '7f'. (NCT02483611)
Timeframe: This measure of heart rate was performed 90 minutes after the traqueal intubation

Interventionbeats/min (Median)
Group M66.00
Group ML61.00
Group C61.00

Latency

"The latency is computed as the elapsed time to reduce the response of T1 to 5% of the initial contraction force after the infusion of cisatracurium.~This outcome meansure was presented in seconds." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes

Interventionseconds (Mean)
Group M139.70
Group ML151.30
Group C147.80

MAP - M1 (Mean Arterial Pressure in the Moment 1)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as in the arrival of the patient in the operating room. This time point was named as moment '1'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed when the patient arrived in the operating room

InterventionmmHg (Mean)
Group M94.63
Group ML88.75
Group C100.10

MAP - M2 (Mean Arterial Pressure in the Moment 2)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as in the moment immediately before the anesthesia induction. This time point was named as moment '2'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed immediately before induction of anesthesia

InterventionmmHg (Mean)
Group M87.63
Group ML84.69
Group C92.47

MAP - M3 (Mean Arterial Pressure in the Moment 3)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution). This time point was named as moment '3'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution)

InterventionmmHg (Mean)
Group M75.88
Group ML73.88
Group C76.73

MAP - M4 (Mean Arterial Pressure in the Moment 4)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as in the end of the study solutions infusion.This time point was named as moment '4'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed five minutes after M3 (in the end of the X and Y solutions infusion)

InterventionmmHg (Median)
Group M69.00
Group ML63.00
Group C74.00

MAP - M5 (Mean Arterial Pressure in the Moment 5)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as immediately before the tracheal intubation. This time point was named as moment '5'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed immediately before the tracheal intubation

InterventionmmHg (Median)
Group M62.50
Group ML61.50
Group C67.00

MAP - M6 (Mean Arterial Pressure in the Moment 6)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as one minute after the tracheal intubation. This time point was named as moment '6'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed one minute after the tracheal intubation

InterventionmmHg (Median)
Group M64.50
Group ML64.00
Group C69.00

MAP - M7a (Mean Arterial Pressure in the Moment 7a)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 15 minutes after the traqueal intubation. This time point was named as moment '7a'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 15 minutes after the traqueal intubation

InterventionmmHg (Median)
Group M66.00
Group ML61.50
Group C69.00

MAP - M7b (Mean Arterial Pressure in the Moment 7b)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 30 minutes after the traqueal intubation. This time point was named as moment '7b'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 30 minutes after the traqueal intubation

InterventionmmHg (Median)
Group M66.50
Group ML63.50
Group C68.00

MAP - M7c (Mean Arterial Pressure in the Moment 7c)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 45 minutes after the traqueal intubation. This time point was named as moment '7c'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 45 minutes after the traqueal intubation

InterventionmmHg (Mean)
Group M69.25
Group ML63.00
Group C69.00

MAP - M7d (Mean Arterial Pressure in the Moment 7d)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 60 minutes after the traqueal intubation. This time point was named as moment '7d'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 60 minutes after the traqueal intubation

InterventionmmHg (Median)
Group M68.00
Group ML62.00
Group C66.00

MAP - M7e (Mean Arterial Pressure in the Moment 7e)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 75 minutes after the traqueal intubation. This time point was named as moment '7e'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 75 minutes after the traqueal intubation

InterventionmmHg (Median)
Group M68.00
Group ML66.00
Group C69.00

MAP - M7f (Mean Arterial Pressure in the Moment 7f)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 90 minutes after the traqueal intubation. This time point was named as moment '7f'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 90 minutes after the traqueal intubation

InterventionmmHg (Median)
Group M64.00
Group ML64.50
Group C72.00

Recovery Index

"The recovery index is the elapsed time between the T1 recovery =25% (Dur25%) and T1 =75% (Dur75%) after the infusion of cisatracurium.~This outcome meansure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes

Interventionminutes (Mean)
Group M20.08
Group ML20.26
Group C14.53

Spontaneous Recovery (T4/T1=90%)

"Spontaneous recovery is the elapsed time for the recovery of the TOF (T4 / T1) response to 90% of the original after infusion of cisatracurium.~This outcome measure was presented in minutes." (NCT02483611)
Timeframe: The participants were followed during the anesthetic - surgical procedure

Interventionminutes (Mean)
Group M120.20
Group ML126.70
Group C90.03

Total Duration (Dur95%)

"The total duration is the elapsed time for T1 recovery of the response to reach 95% of the initial after the infusion of cisatracurium.~This outcome measure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes

Interventionminutes (Mean)
Group M113.20
Group ML120.10
Group C88.19

Reviews

1 review available for procaine and Apnea

ArticleYear
Local anesthetic drugs: tissue and systemic toxicity.
    Acta anaesthesiologica Belgica, 1981, Volume: 32, Issue:4

    Topics: Anesthesia, Conduction; Anesthetics, Local; Animals; Apnea; Arrhythmias, Cardiac; Barbiturates; Cent

1981

Other Studies

14 other studies available for procaine and Apnea

ArticleYear
Novocaine and complex respiratory rhythms of toxic origin (nicotine, acetylcholine) suppression of apnea, maintenance of the polypnetic crisis.
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1947, Volume: 141, Issue:3-4

    Topics: Acetylcholine; Apnea; Humans; Nicotine; Procaine; Respiration

1947
Urine secretion during diffusion respiration following apnea induced by intracisternal injection of procaine hydrochloride.
    Anesthesiology, 1955, Volume: 16, Issue:5

    Topics: Anuria; Apnea; Injections; Kidney; Procaine; Respiration

1955
INVESTIGATION OF RESPIRATORY AND CIRCULATORY EFFECTS OF ETHAMIVAN IN THE DOG AND CAT.
    British journal of anaesthesia, 1964, Volume: 36

    Topics: Amines; Aorta; Apnea; Atropine; Benzamides; Blood Pressure; Bradycardia; Carotid Arteries; Cats; Cen

1964
THE RESPIRATORY FACTOR IN ANGIOGRAPHIC MEDIA TOXICITY.
    Radiology, 1965, Volume: 84

    Topics: Angiography; Animals; Apnea; Arrhythmias, Cardiac; Atropine; Blood Pressure; Contrast Media; Dextran

1965
Medullary surface chemoreceptors and regulation of respiration in the cat.
    Journal of applied physiology, 1967, Volume: 22, Issue:1

    Topics: Animals; Apnea; Blood Pressure; Carbon Dioxide; Cats; Chloralose; Decerebrate State; Denervation; Me

1967
Pseudocholinesterase levels and rates of chloroprocaine hydrolysis in patients receiving adequate doses of phospholine iodide.
    Anesthesiology, 1980, Volume: 52, Issue:5

    Topics: Apnea; Butyrylcholinesterase; Cholinesterases; Echothiophate Iodide; Humans; Procaine; Succinylcholi

1980
[Peripheral paralysis or "bulbar threat"? (Further comment on the pathogenesis of respiratory arrest and vascular collapse during cerebrospinal anesthesia)].
    Vestnik khirurgii imeni I. I. Grekova, 1978, Volume: 121, Issue:7

    Topics: Anesthesia, Spinal; Animals; Apnea; Blood Pressure; Bulbar Palsy, Progressive; Dibucaine; Dogs; Hear

1978
Survey of local anesthetic toxicity in the families of patients with atypical plasma cholinesterase.
    Journal of oral surgery (American Dental Association : 1965), 1975, Volume: 33, Issue:11

    Topics: Anesthetics, Local; Apnea; Benzoylcholine; Cholinesterases; Dibucaine; Heterozygote; Homozygote; Hum

1975
[Complications of regional anaesthesia and their treatment (author's transl)].
    Munchener medizinische Wochenschrift (1950), 1973, Oct-12, Volume: 115, Issue:41

    Topics: Adrenal Cortex Hormones; Anesthesia, Local; Apnea; Barbiturates; Bradycardia; Bupivacaine; Diagnosis

1973
[Advantages of neuroleptic analgesia in arteriographic studies (experiences with Thalamonal)].
    Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1971, Volume: 114, Issue:5

    Topics: Adolescent; Adult; Aged; Angiography; Apnea; Benperidol; Blood Pressure; Drug Eruptions; Drug Hypers

1971
Effects of intravenous and intra-arterial procaine and lidocaine on neuromuscular transmission in man.
    Acta anaesthesiologica Scandinavica. Supplementum, 1969, Volume: 36

    Topics: Apnea; Drug Synergism; Humans; Injections, Intra-Arterial; Injections, Intravenous; Lidocaine; Muscl

1969
Respiratory responses to chemical pulses in the cerebrospinal fluid of cats.
    British journal of pharmacology, 1972, Volume: 44, Issue:4

    Topics: Acetylcholine; Animals; Apnea; Benzamides; Blood Pressure; Brain; Carbon Dioxide; Cats; Cerebrospina

1972
[Role of "specific" and non-specific afferent fibers in the drive of respiration, studied by stimulation and blockade of afferent fibers in decerebrate cats].
    Pflugers Archiv : European journal of physiology, 1969, Volume: 312, Issue:4

    Topics: Animals; Apnea; Carbon Dioxide; Cats; Cold Temperature; Decerebrate State; Electric Stimulation; Glo

1969
Abnormal reaction to procaine and succinylcholine in a patient with inherited atypical plasma cholinesterase: case report.
    Canadian Anaesthetists' Society journal, 1968, Volume: 15, Issue:5

    Topics: Abdomen; Adjuvants, Anesthesia; Adult; Anesthesia, Local; Apnea; Cholinesterases; Drug Hypersensitiv

1968