procaine has been researched along with Apnea in 15 studies
Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
Apnea: A transient absence of spontaneous respiration.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Because of these reports, 23 patients with prolonged apnea after administration of succinylcholine were studied with Kalow's method for abnormal dibucaine number (DN), which characterizes this condition, and for the history of local anesthetic toxicity." | 3.65 | Survey of local anesthetic toxicity in the families of patients with atypical plasma cholinesterase. ( Eilderton, TE; Zsigmond, EK, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HAZARD, R | 1 |
| CHEYMOL, J | 1 |
| QUINQUAND, A | 1 |
| IRWIN, RL | 1 |
| STONE, JE | 1 |
| DRAPER, WB | 1 |
| WHITEHEAD, RW | 1 |
| CAMPBELL, JR | 1 |
| LAWSON, DD | 1 |
| SANFORD, J | 1 |
| BERNSTEIN, EF | 1 |
| Cozine, RA | 1 |
| Ngai, SH | 1 |
| Moore, DC | 1 |
| Lanks, KW | 1 |
| Sklar, GS | 1 |
| Geshelin, SA | 1 |
| Zsigmond, EK | 2 |
| Eilderton, TE | 2 |
| Sehhati, G | 1 |
| Frey, R | 1 |
| Mildner, R | 1 |
| Heissen, E | 1 |
| Teske, HJ | 1 |
| Haller, J | 1 |
| Katz, RL | 1 |
| Gissen, AJ | 1 |
| Borison, HL | 1 |
| Haranath, PS | 1 |
| McCarthy, LE | 1 |
| Schläfke, ME | 1 |
| See, WR | 1 |
| Massion, WH | 1 |
| Loeschcke, HH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Intravenous Infusion of Magnesium Sulfate Associated or Not to Lidocaine On the Neuromuscular Blockade Induced by Muscle Relaxant Cistracurium[NCT02483611] | Phase 4 | 48 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The clinical duration is the elapsed time for T1 recovery = 25% (Dur25%) of the original value of T1 after the infusion of cisatracurium.~This outcome meansure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes
| Intervention | minutes (Median) |
|---|---|
| Group M | 82.68 |
| Group ML | 86.33 |
| Group C | 64.8 |
"The final recovery index is the elapsed time between the T1 recovery = 25% (Dur25%) and T4 / T1 = 80% (TOF = 80%) after the infusion of cisatracurium.~This outcome measure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes
| Intervention | minutes (Mean) |
|---|---|
| Group M | 27.97 |
| Group ML | 33.81 |
| Group C | 21.51 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The measure of heart rate was recorded and annotated at various times such as in the arrival of the patient in the operating room. This time point was named as moment '1'. (NCT02483611)
Timeframe: This measure of heart rate was performed when the patient arrived in the operating room
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 79.94 |
| Group ML | 77.25 |
| Group C | 73.66 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as in the moment immediately before the anesthesia induction. This time point was named as moment '2'. (NCT02483611)
Timeframe: This measure of heart rate was performed immediately before induction of anesthesia
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 74.69 |
| Group ML | 73.69 |
| Group C | 75.40 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution). This time point was named as moment '3'. (NCT02483611)
Timeframe: This measure of heart rate was performed immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution)
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 72.94 |
| Group ML | 74.19 |
| Group C | 75.40 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as in the end of the study solutions infusion. This time point was named as moment '4'. (NCT02483611)
Timeframe: This measure of heart rate was performed five minutes after M3 (in the end of the X and Y solutions infusion)
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 71.94 |
| Group ML | 72.25 |
| Group C | 65.07 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as immediately before the tracheal intubation. This time point was named as moment '5'. (NCT02483611)
Timeframe: This measure of heart rate was performed immediately before the tracheal intubation
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 67.56 |
| Group ML | 69.31 |
| Group C | 64.27 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as one minute after the tracheal intubation. This time point was named as moment '6'. (NCT02483611)
Timeframe: This measure of heart rate was performed one minute after the tracheal intubation
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 66.50 |
| Group ML | 68.19 |
| Group C | 65.13 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 15 minutes after the traqueal intubation.This time point was named as moment '7a'. (NCT02483611)
Timeframe: This measure of heart rate was performed 15 minutes after the traqueal intubation
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 68.94 |
| Group ML | 68.19 |
| Group C | 67.13 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 30 minutes after the traqueal intubation. This time point was named as moment '7b'. (NCT02483611)
Timeframe: This measure of heart rate was performed 30 minutes after the traqueal intubation
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 67.44 |
| Group ML | 68.38 |
| Group C | 64.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 45 minutes after the traqueal intubation. This time point was named as moment '7c'. (NCT02483611)
Timeframe: This measure of heart rate was performed 45 minutes after the traqueal intubation
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 65.75 |
| Group ML | 65.75 |
| Group C | 62.33 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 60 minutes after the traqueal intubation. This time point was named as moment '7d'. (NCT02483611)
Timeframe: This measure of heart rate was performed 60 minutes after the traqueal intubation
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 66.19 |
| Group ML | 65.31 |
| Group C | 61.93 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 75 minutes after the traqueal intubation. This time point was named as moment '7e'. (NCT02483611)
Timeframe: This measure of heart rate was performed 75 minutes after the traqueal intubation
| Intervention | beats/min (Median) |
|---|---|
| Group M | 66.50 |
| Group ML | 63.00 |
| Group C | 58.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 90 minutes after the traqueal intubation. This time point was named as moment '7f'. (NCT02483611)
Timeframe: This measure of heart rate was performed 90 minutes after the traqueal intubation
| Intervention | beats/min (Median) |
|---|---|
| Group M | 66.00 |
| Group ML | 61.00 |
| Group C | 61.00 |
"The latency is computed as the elapsed time to reduce the response of T1 to 5% of the initial contraction force after the infusion of cisatracurium.~This outcome meansure was presented in seconds." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes
| Intervention | seconds (Mean) |
|---|---|
| Group M | 139.70 |
| Group ML | 151.30 |
| Group C | 147.80 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as in the arrival of the patient in the operating room. This time point was named as moment '1'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed when the patient arrived in the operating room
| Intervention | mmHg (Mean) |
|---|---|
| Group M | 94.63 |
| Group ML | 88.75 |
| Group C | 100.10 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as in the moment immediately before the anesthesia induction. This time point was named as moment '2'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed immediately before induction of anesthesia
| Intervention | mmHg (Mean) |
|---|---|
| Group M | 87.63 |
| Group ML | 84.69 |
| Group C | 92.47 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution). This time point was named as moment '3'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution)
| Intervention | mmHg (Mean) |
|---|---|
| Group M | 75.88 |
| Group ML | 73.88 |
| Group C | 76.73 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as in the end of the study solutions infusion.This time point was named as moment '4'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed five minutes after M3 (in the end of the X and Y solutions infusion)
| Intervention | mmHg (Median) |
|---|---|
| Group M | 69.00 |
| Group ML | 63.00 |
| Group C | 74.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as immediately before the tracheal intubation. This time point was named as moment '5'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed immediately before the tracheal intubation
| Intervention | mmHg (Median) |
|---|---|
| Group M | 62.50 |
| Group ML | 61.50 |
| Group C | 67.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as one minute after the tracheal intubation. This time point was named as moment '6'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed one minute after the tracheal intubation
| Intervention | mmHg (Median) |
|---|---|
| Group M | 64.50 |
| Group ML | 64.00 |
| Group C | 69.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 15 minutes after the traqueal intubation. This time point was named as moment '7a'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 15 minutes after the traqueal intubation
| Intervention | mmHg (Median) |
|---|---|
| Group M | 66.00 |
| Group ML | 61.50 |
| Group C | 69.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 30 minutes after the traqueal intubation. This time point was named as moment '7b'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 30 minutes after the traqueal intubation
| Intervention | mmHg (Median) |
|---|---|
| Group M | 66.50 |
| Group ML | 63.50 |
| Group C | 68.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 45 minutes after the traqueal intubation. This time point was named as moment '7c'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 45 minutes after the traqueal intubation
| Intervention | mmHg (Mean) |
|---|---|
| Group M | 69.25 |
| Group ML | 63.00 |
| Group C | 69.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 60 minutes after the traqueal intubation. This time point was named as moment '7d'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 60 minutes after the traqueal intubation
| Intervention | mmHg (Median) |
|---|---|
| Group M | 68.00 |
| Group ML | 62.00 |
| Group C | 66.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 75 minutes after the traqueal intubation. This time point was named as moment '7e'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 75 minutes after the traqueal intubation
| Intervention | mmHg (Median) |
|---|---|
| Group M | 68.00 |
| Group ML | 66.00 |
| Group C | 69.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 90 minutes after the traqueal intubation. This time point was named as moment '7f'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 90 minutes after the traqueal intubation
| Intervention | mmHg (Median) |
|---|---|
| Group M | 64.00 |
| Group ML | 64.50 |
| Group C | 72.00 |
"The recovery index is the elapsed time between the T1 recovery =25% (Dur25%) and T1 =75% (Dur75%) after the infusion of cisatracurium.~This outcome meansure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes
| Intervention | minutes (Mean) |
|---|---|
| Group M | 20.08 |
| Group ML | 20.26 |
| Group C | 14.53 |
"Spontaneous recovery is the elapsed time for the recovery of the TOF (T4 / T1) response to 90% of the original after infusion of cisatracurium.~This outcome measure was presented in minutes." (NCT02483611)
Timeframe: The participants were followed during the anesthetic - surgical procedure
| Intervention | minutes (Mean) |
|---|---|
| Group M | 120.20 |
| Group ML | 126.70 |
| Group C | 90.03 |
"The total duration is the elapsed time for T1 recovery of the response to reach 95% of the initial after the infusion of cisatracurium.~This outcome measure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes
| Intervention | minutes (Mean) |
|---|---|
| Group M | 113.20 |
| Group ML | 120.10 |
| Group C | 88.19 |
1 review available for procaine and Apnea
| Article | Year |
|---|---|
Local anesthetic drugs: tissue and systemic toxicity.
Topics: Anesthesia, Conduction; Anesthetics, Local; Animals; Apnea; Arrhythmias, Cardiac; Barbiturates; Cent | 1981 |
14 other studies available for procaine and Apnea
| Article | Year |
|---|---|
Novocaine and complex respiratory rhythms of toxic origin (nicotine, acetylcholine) suppression of apnea, maintenance of the polypnetic crisis.
Topics: Acetylcholine; Apnea; Humans; Nicotine; Procaine; Respiration | 1947 |
Urine secretion during diffusion respiration following apnea induced by intracisternal injection of procaine hydrochloride.
Topics: Anuria; Apnea; Injections; Kidney; Procaine; Respiration | 1955 |
INVESTIGATION OF RESPIRATORY AND CIRCULATORY EFFECTS OF ETHAMIVAN IN THE DOG AND CAT.
Topics: Amines; Aorta; Apnea; Atropine; Benzamides; Blood Pressure; Bradycardia; Carotid Arteries; Cats; Cen | 1964 |
THE RESPIRATORY FACTOR IN ANGIOGRAPHIC MEDIA TOXICITY.
Topics: Angiography; Animals; Apnea; Arrhythmias, Cardiac; Atropine; Blood Pressure; Contrast Media; Dextran | 1965 |
Medullary surface chemoreceptors and regulation of respiration in the cat.
Topics: Animals; Apnea; Blood Pressure; Carbon Dioxide; Cats; Chloralose; Decerebrate State; Denervation; Me | 1967 |
Pseudocholinesterase levels and rates of chloroprocaine hydrolysis in patients receiving adequate doses of phospholine iodide.
Topics: Apnea; Butyrylcholinesterase; Cholinesterases; Echothiophate Iodide; Humans; Procaine; Succinylcholi | 1980 |
[Peripheral paralysis or "bulbar threat"? (Further comment on the pathogenesis of respiratory arrest and vascular collapse during cerebrospinal anesthesia)].
Topics: Anesthesia, Spinal; Animals; Apnea; Blood Pressure; Bulbar Palsy, Progressive; Dibucaine; Dogs; Hear | 1978 |
Survey of local anesthetic toxicity in the families of patients with atypical plasma cholinesterase.
Topics: Anesthetics, Local; Apnea; Benzoylcholine; Cholinesterases; Dibucaine; Heterozygote; Homozygote; Hum | 1975 |
[Complications of regional anaesthesia and their treatment (author's transl)].
Topics: Adrenal Cortex Hormones; Anesthesia, Local; Apnea; Barbiturates; Bradycardia; Bupivacaine; Diagnosis | 1973 |
[Advantages of neuroleptic analgesia in arteriographic studies (experiences with Thalamonal)].
Topics: Adolescent; Adult; Aged; Angiography; Apnea; Benperidol; Blood Pressure; Drug Eruptions; Drug Hypers | 1971 |
Effects of intravenous and intra-arterial procaine and lidocaine on neuromuscular transmission in man.
Topics: Apnea; Drug Synergism; Humans; Injections, Intra-Arterial; Injections, Intravenous; Lidocaine; Muscl | 1969 |
Respiratory responses to chemical pulses in the cerebrospinal fluid of cats.
Topics: Acetylcholine; Animals; Apnea; Benzamides; Blood Pressure; Brain; Carbon Dioxide; Cats; Cerebrospina | 1972 |
[Role of "specific" and non-specific afferent fibers in the drive of respiration, studied by stimulation and blockade of afferent fibers in decerebrate cats].
Topics: Animals; Apnea; Carbon Dioxide; Cats; Cold Temperature; Decerebrate State; Electric Stimulation; Glo | 1969 |
Abnormal reaction to procaine and succinylcholine in a patient with inherited atypical plasma cholinesterase: case report.
Topics: Abdomen; Adjuvants, Anesthesia; Adult; Anesthesia, Local; Apnea; Cholinesterases; Drug Hypersensitiv | 1968 |