procaine has been researched along with Alloxan Diabetes in 8 studies
Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In addition, the slope factor (steepness) of the dose-response relation was lowered 4-fold." | 1.30 | Norepinephrine-mediated calcium signaling is altered in vascular smooth muscle of diabetic rat. ( Bielefeld, DR; Cohen, RM; Ferguson, DG; Lorenz, JN; Pun, RY; Tam, ES, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Song, M | 1 |
| Chen, Y | 1 |
| Nassar, CF | 3 |
| Shayban, ES | 1 |
| Nasser, MG | 2 |
| Dibu, RG | 1 |
| Tam, ES | 1 |
| Ferguson, DG | 1 |
| Bielefeld, DR | 1 |
| Lorenz, JN | 1 |
| Cohen, RM | 1 |
| Pun, RY | 1 |
| Hearse, DJ | 1 |
| Stewart, DA | 1 |
| Green, DG | 1 |
| Kalichman, MW | 1 |
| Calcutt, NA | 1 |
| Karkaji, EG | 1 |
| Habbal, ZM | 1 |
| Shevchuk, IA | 1 |
| Mel'nik, TF | 1 |
| Sanduliak, LI | 1 |
| Kashina, IM | 1 |
| Mardar', AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Difference in Duration of Sciatic Nerve Block Between Diabetic and Non-diabetic Patients[NCT02482831] | 53 participants (Anticipated) | Observational | 2014-09-30 | Recruiting | |||
| Can Ultrasound Predict Nerve Injury Following Posterior Tibial Nerve Block in Patients With Peripheral Neuropathy?[NCT01002053] | 40 participants (Actual) | Observational | 2012-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for procaine and Alloxan Diabetes
| Article | Year |
|---|---|
Local anaesthetic procaine derivatives protect rat against diabetic nephropathy via inhibition of DPP-4, inflammation and oxidative stress.
Topics: Anesthetics, Local; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Inflammation; | 2023 |
Calcium binding to normal, regenerating and diabetic liver plasma membrane.
Topics: Animals; Binding Sites; Calcium; Cell Membrane; Colchicine; Diabetes Mellitus, Experimental; In Vitr | 1984 |
Pyridoxine binding to normal and diabetic liver plasma membrane.
Topics: Animals; Binding Sites; Cell Membrane; Colchicine; Diabetes Mellitus, Experimental; Insulin; Liver; | 1984 |
Norepinephrine-mediated calcium signaling is altered in vascular smooth muscle of diabetic rat.
Topics: Animals; Calcium; Calcium-Binding Proteins; Cells, Cultured; Diabetes Mellitus, Experimental; Dose-R | 1997 |
Myocardial susceptibility to ischemic damage: a comparative study of disease models in the rat.
Topics: Adenosine Triphosphate; Animals; Cardiac Output; Cardiomegaly; Coronary Circulation; Coronary Diseas | 1978 |
Local anesthetic-induced conduction block and nerve fiber injury in streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Lidocaine; Nerve Fibers; Neural Conduction; Procai | 1992 |
Local anesthetic-induced conduction block and nerve fiber injury in streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Lidocaine; Nerve Fibers; Neural Conduction; Procai | 1992 |
Local anesthetic-induced conduction block and nerve fiber injury in streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Lidocaine; Nerve Fibers; Neural Conduction; Procai | 1992 |
Local anesthetic-induced conduction block and nerve fiber injury in streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Lidocaine; Nerve Fibers; Neural Conduction; Procai | 1992 |
Dopamine receptors in normal and diabetic liver plasma membrane.
Topics: Animals; Cell Membrane; Diabetes Mellitus, Experimental; In Vitro Techniques; Insulin; Liver; Procai | 1986 |
[Experimental study of the content and histotopography of zinc in the pancreas].
Topics: Adrenal Glands; Adrenalectomy; Animals; Blood Glucose; Castration; Cobalt; Desoxycorticosterone; Dia | 1974 |