procaine has been researched along with Aging in 67 studies
Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To test the effects of aging on conduction block, equipotent doses of bupivacaine (0." | 7.69 | Effects of aging on nerve conduction block induced by bupivacaine and procaine in rats. ( Kalichman, MW; Yee, TC, 1997) |
| "Since its discovery in 1905 and its employment in everyday medical practice as a local anesthetic, to its highly controversial endorsement as an "anti-aging" molecule in the sixties and seventies, procaine is part of the history of medicine and gerontoprophylaxis." | 5.12 | Procaine-The Controversial Geroprotector Candidate: New Insights Regarding Its Molecular and Cellular Effects. ( Bürkle, A; Gradinaru, D; Margina, D; Moreno-Villanueva, M; Ungurianu, A, 2021) |
| "Many of the neurochemical changes associated with aging brain, particularly lower choline acetyltransferase and higher monoamine oxidase, occur with greater severity in senile dementia, Alzheimer's type (SDAT)." | 4.76 | Chemotherapy of cognitive disorders in geriatric subjects. ( Gershon, S; Goodnick, P, 1984) |
| "In aging eyes phenylephrine drops have no significant effect on the depth of the anterior chamber, whereas pilocarpine drops produce a significant shallowing." | 3.66 | Acute shallowing of the anterior chamber. ( Mapstone, R, 1981) |
| "This article is a review and evaluation of the world literature on the systemic use of procaine in the treatment of the aging process and the common chronic diseases of later life." | 3.65 | The systemic use of procaine in the treatment of the elderly: a review. ( Ostfeld, A; Smith, CM; Stotsky, BA, 1977) |
| "The area of punctate hyperalgesia was maintained in older adults over 4 h, while it declined in the young." | 2.74 | The effect of local anaesthetic on age-related capsaicin-induced mechanical hyperalgesia--a randomised, controlled study. ( Gibson, SJ; Helme, RD; McMeeken, JM; Zheng, Z, 2009) |
| "d-tubocurarine and procaine have been shown to inhibit the acetylcholinesterase of rat brain homogenate by coupled and non-competitive mechanism respectively, which suggests binding to enzyme peripheral sites." | 1.26 | [Age changes in the allosteric properties of brain acetylcholinesterase]. ( Aksentsev, SL; Arinchin, NI; Konev, SV; Miliutin, AA; Okun', IM, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 59 (88.06) | 18.7374 |
| 1990's | 4 (5.97) | 18.2507 |
| 2000's | 2 (2.99) | 29.6817 |
| 2010's | 1 (1.49) | 24.3611 |
| 2020's | 1 (1.49) | 2.80 |
| Authors | Studies |
|---|---|
| Gradinaru, D | 1 |
| Ungurianu, A | 1 |
| Margina, D | 1 |
| Moreno-Villanueva, M | 1 |
| Bürkle, A | 1 |
| Perls, T | 1 |
| Zheng, Z | 1 |
| Gibson, SJ | 1 |
| Helme, RD | 1 |
| McMeeken, JM | 1 |
| Adam, D | 1 |
| Federspil, P | 1 |
| Lukes, M | 1 |
| Petrowicz, O | 1 |
| GIOTTI, A | 1 |
| PARHON, CI | 1 |
| ASLAN, A | 3 |
| DAVID, C | 2 |
| PIRO, S | 1 |
| DI CRISTO, G | 1 |
| GRASSI, B | 1 |
| TRONCONI, V | 1 |
| MONTANARI, M | 1 |
| ZANETTI, R | 1 |
| VERZAR, F | 1 |
| BERGER, P | 1 |
| SKULA, E | 1 |
| JEZDINSKY, J | 1 |
| VIEILLEFOSSE, R | 1 |
| HANEGRAAFF, C | 1 |
| KONIECZNY, W | 1 |
| SCARDIGLI, G | 1 |
| VRABIESCU, A | 1 |
| DOMILESCU, C | 1 |
| CAMPEANU, L | 1 |
| COSTINIU, M | 1 |
| STANESCU, S | 1 |
| COSMOVICI, NL | 1 |
| SIMON, IS | 1 |
| SHOSTENKO, IuV | 1 |
| Peferoen, M | 1 |
| Fransen, P | 1 |
| De Loof, A | 1 |
| Goodnick, P | 1 |
| Gershon, S | 2 |
| Hall, MR | 1 |
| Briggs, RS | 1 |
| MacLennan, WJ | 1 |
| Marcer, D | 1 |
| Robinson, MJ | 1 |
| Everett, FM | 1 |
| Mal'tsev, EV | 1 |
| Mapstone, R | 1 |
| Bai, F | 1 |
| Michel, R | 1 |
| Rossignol, P | 1 |
| Bhaskaran, D | 1 |
| Radha, E | 1 |
| Thomas, R | 1 |
| Kent, S | 2 |
| Zistl, A | 1 |
| Draeger, J | 1 |
| Drescher, K | 1 |
| Timm, J | 1 |
| Schloot, W | 1 |
| Kanowski, S | 1 |
| Kulaev, BS | 1 |
| Bursian, AV | 1 |
| Semenova, IuO | 1 |
| Ungemach, FR | 1 |
| Yee, TC | 1 |
| Kalichman, MW | 1 |
| Jarvik, LF | 1 |
| Milne, JF | 1 |
| Ostfeld, A | 1 |
| Smith, CM | 1 |
| Stotsky, BA | 1 |
| Vanker, AD | 1 |
| Mizukami, H | 1 |
| Clemens, JA | 1 |
| Fuller, RW | 1 |
| Karmazyn, M | 1 |
| Horrobin, DF | 1 |
| Oka, M | 1 |
| Manku, MS | 1 |
| Ally, AI | 1 |
| Karmali, RA | 1 |
| Morgan, RO | 1 |
| Cunnane, SC | 1 |
| Gressner, E | 1 |
| Miliutin, AA | 1 |
| Okun', IM | 1 |
| Aksentsev, SL | 1 |
| Arinchin, NI | 1 |
| Konev, SV | 1 |
| Mabeck, CE | 1 |
| Andreasen, PB | 1 |
| Heynen, AJ | 1 |
| Bilkey, DK | 1 |
| Schneider, EL | 1 |
| Reed, JD | 1 |
| Comfort, A | 1 |
| Kline, NS | 1 |
| Kroath, F | 1 |
| Sakalis, G | 1 |
| Oh, D | 1 |
| Shopsin, B | 1 |
| Hunecke, I | 1 |
| Bunge, HC | 1 |
| Hochschild, R | 1 |
| Jarvik, ME | 1 |
| Gritz, ER | 1 |
| Schneider, NG | 1 |
| Cohen, S | 1 |
| Ditman, KS | 1 |
| Lemaire, A | 1 |
| MacFarlane, MD | 1 |
| Weiss, O | 1 |
| von Raffler, E | 1 |
| Sarama, E | 1 |
| Piscitelli, J | 1 |
| Bottecchia, G | 1 |
| Pesaro, F | 1 |
| Salmeri, G | 1 |
| Heinitz, M | 1 |
| Enăchescu, G | 1 |
| Carca, AS | 1 |
| Dutren, AM | 1 |
| Lassmann, H | 1 |
| Plenk, H | 1 |
| Bode, G | 1 |
6 reviews available for procaine and Aging
| Article | Year |
|---|---|
Procaine-The Controversial Geroprotector Candidate: New Insights Regarding Its Molecular and Cellular Effects.
Topics: Aging; Anesthetics, Local; Animals; Antioxidants; Epigenesis, Genetic; Humans; Procaine | 2021 |
Chemotherapy of cognitive disorders in geriatric subjects.
Topics: Adrenocorticotropic Hormone; Aged; Aging; Alzheimer Disease; Arecoline; Brain Chemistry; Choline; Co | 1984 |
[Conservative treatment of cataract].
Topics: Acridines; Aged; Aging; Cataract; Crystallins; Cysteine; Drug Therapy, Combination; Humans; Hypercho | 1984 |
Chemical manipulation of some aspects of aging.
Topics: Aging; Animals; Ergolines; Estrus; Female; Humans; Longevity; Male; Monoamine Oxidase Inhibitors; Pi | 1978 |
Life extension.
Topics: Aged; Aging; Animals; Antioxidants; Dehydroepiandrosterone; Diet; Energy Intake; Ethics, Medical; Fe | 1985 |
Drugs and memory disorders in human aging.
Topics: Adolescent; Adult; Aged; Aging; Amphetamine; Anticonvulsants; Antidepressive Agents; Arousal; Caffei | 1972 |
9 trials available for procaine and Aging
| Article | Year |
|---|---|
The effect of local anaesthetic on age-related capsaicin-induced mechanical hyperalgesia--a randomised, controlled study.
Topics: Adult; Aged; Aging; Analysis of Variance; Anesthetics, Local; Capsaicin; Female; Humans; Hyperalgesi | 2009 |
Therapeutic properties and tolerance of procaine and phenazone containing ear drops in infants and very young children.
Topics: Aging; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Child; Child, Presch | 2009 |
The effects of procaine/haematoporphyrin on age-related decline: a double-blind trial.
Topics: Aged; Aging; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Hematoporphyr | 1983 |
The procaine "youth" drugs.
Topics: Aged; Aging; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Hematoporphyr | 1982 |
Gerovital H3.
Topics: Aged; Aging; Clinical Trials as Topic; Humans; Mental Disorders; Procaine | 1979 |
Letter: Effect of procaine on ageing.
Topics: Aged; Aging; Clinical Trials as Topic; Depression; Drug Evaluation; Humans; Procaine; United States; | 1973 |
A trial of Gerovital H-3 in depression during senility.
Topics: Aged; Aging; Antidepressive Agents; Arteriosclerosis; Clinical Trials as Topic; Depression; Humans; | 1974 |
Gerovital H3 in the treatment of the depressed aging patient.
Topics: Adult; Aged; Aging; Anxiety; Clinical Trials as Topic; Depression; Drug Evaluation; Female; Humans; | 1974 |
[On oral procaine therapy].
Topics: Adult; Aged; Aging; Female; Geriatrics; Humans; Male; Middle Aged; Procaine | 1969 |
52 other studies available for procaine and Aging
| Article | Year |
|---|---|
The reappearance of procaine hydrochloride (Gerovital H3) for antiaging.
Topics: Aging; Anesthetics, Local; Drug Approval; Female; Humans; Male; Procaine; Rejuvenation | 2013 |
[From procaine as a membrane-stabilizing drug to procaine as a rejuvenation factor].
Topics: Aging; Humans; Membranes; Procaine; Rejuvenation | 1958 |
[Preventive treatment and cure of aging phenomena; action of novocaine as eutrophic and rejuvenating factor].
Topics: Aging; Procaine; Rejuvenation | 1957 |
[Experiences in the realm of therapy of the aging man].
Topics: Aging; Geriatrics; Procaine | 1960 |
[Contribution to the study of the treatment of neuropsychiatric forms of senility: procaine therapy].
Topics: Aging; Dementia; Mental Disorders; Procaine; Psychotic Disorders | 1960 |
[Initial results and proposals for procaine-placental therapy of the processes of organic aging].
Topics: Aging; Cell- and Tissue-Based Therapy; Female; Placenta; Pregnancy; Procaine; Rejuvenation | 1959 |
Note on the influence of procain (novocain), paraaminobenzoicacid or diethylethanolamin on the ageing of rats.
Topics: 4-Aminobenzoic Acid; Aging; Amino Alcohols; Animals; Procaine; Rats | 1959 |
[The effects of chronic procaine treatment of senescence of the white rat. First results].
Topics: Aging; Animals; Procaine; Rats | 1960 |
[Our experiences with treatment of diseases of aging with procaine by the Parhon and Aslanova method].
Topics: Aged; Aged, 80 and over; Aging; Arteriosclerosis; Procaine | 1962 |
[The aging of adrenaline-containing local anesthetic solutions. II. Preservation of local anesthetics. Changes in local anesthetic activity and toxicity].
Topics: Aging; Anesthetics; Anesthetics, Local; Epinephrine; Humans; Procaine; Tetracaine | 1962 |
[EFFECT OF NOVOCAINE PREPARATIONS ON THE METABOLISM OF NITROGEN IN OLD RATS].
Topics: Aging; Body Weight; Nitrogen; Pharmacology; Procaine; Proteins; Rats; Research | 1963 |
[OLD AND NEW CONSIDERATIONS ON THE SO-CALLED REJUVENATION CURES].
Topics: Aging; Geriatrics; Hormones; Humans; Placental Extracts; Procaine; Rejuvenation; Vitamin A; Vitamin | 1964 |
LONG-TERM TREATMENT WITH PROCAINE (GEROVITAL H3) IN ALBINO RATS.
Topics: Aging; Body Weight; Electrocardiography; Learning; Life Expectancy; Memory; Nephritis; Nephrosis; Ph | 1965 |
[RESEARCH ON THE CATALASE INDEX OF THE BLOOD SERUM AS A FUNCTION OF AGE AND PATHOLOGICAL CONDITION. INFLUENCE OF GEROVITAL H3].
Topics: Aging; Blood; Catalase; Humans; Procaine; Research; Serum | 1965 |
[DETERMINATION OF THE STORAGE LIFE OF NOVOCAINE SOLUTIONS BY THE METHOD OF ACCELERATED AGING].
Topics: Aging; Chemistry, Pharmaceutical; Pharmacy; Procaine; Research; Solutions | 1965 |
Influence of procaine HCl on larval development, adult lifespan and acid phosphatase activity in Musca domestica L.
Topics: Acid Phosphatase; Aging; Animals; Body Weight; Female; Houseflies; Larva; Male; Procaine; Sex Factor | 1982 |
Acute shallowing of the anterior chamber.
Topics: Acetazolamide; Aged; Aging; Anterior Chamber; Glaucoma; Humans; Intraocular Pressure; Iris; Middle A | 1981 |
Effects of procaine on the oxidative phosphorylation of brain mitochondria from senescent rats.
Topics: Aging; Animals; Brain; In Vitro Techniques; Male; Mitochondria; Oxidative Phosphorylation; Oxygen Co | 1984 |
Murine regional brain monoamine oxidase activity: time- and age-dependent response to inhibitors.
Topics: Aging; Analysis of Variance; Animals; Brain; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; | 1984 |
Procaine. Will it keep you younger longer?
Topics: Aged; Aging; Drug Combinations; Hematoporphyrins; Humans; Neurocognitive Disorders; Procaine; Resear | 1983 |
[Investigations under anesthesia on the effects of endogenous and exogenous factors on corneal sensitivity].
Topics: Adult; Age Factors; Aging; Anesthetics, Local; Cornea; Female; Humans; Male; Middle Aged; Procaine; | 1982 |
[Is aging curable? Advantage of so-called geriatrics].
Topics: Aged; Aging; Brain; Geriatrics; Hormones; Humans; Placebos; Procaine; Vitamins | 1982 |
The state and the goals of the gerontological research at the National Institute of Gerontology and Geriatrics in Romania.
Topics: Aged; Aging; Animals; Antibody Formation; Autoantibodies; Blood Circulation; Capillary Permeability; | 1980 |
[The role of interoceptive afferentation in regulating motor activity in the early postnatal ontogeny of rats].
Topics: Afferent Pathways; Aging; Anesthetics, Local; Animals; Injections, Intraperitoneal; Motor Activity; | 1995 |
[Geriatric drugs in aged dogs?].
Topics: Aging; Animals; Cerebral Hemorrhage; Dog Diseases; Dogs; Hemorrhage; Hormones; Pentoxifylline; Proca | 1994 |
Effects of aging on nerve conduction block induced by bupivacaine and procaine in rats.
Topics: Aging; Anesthetics, Local; Animals; Bupivacaine; Male; Motor Neurons; Neural Conduction; Procaine; R | 1997 |
Gerovital-H3--a review of the literature.
Topics: Aged; Aging; Anesthetics, Local; Anticholesteremic Agents; Dementia; Depression; Humans; Hydrogen-Io | 1975 |
The systemic use of procaine in the treatment of the elderly: a review.
Topics: 4-Aminobenzoic Acid; Adult; Affect; Aged; Aging; Arteriosclerosis; Arthritis; Chronic Disease; Demen | 1977 |
Changes in the activity of acetylcholinesterase from the brain of the Mongolian gerbil (Meriones unguiculatus) with age.
Topics: Acetylcholinesterase; Aging; Animals; Animals, Newborn; Brain; Gerbillinae; Kinetics; Lidocaine; Mep | 1979 |
Changes in coronary vascular resistance associated with prolonged hypoxia in isolated rat hearts: a possible role of prostaglandins.
Topics: Aging; Animals; Aspirin; Chloroquine; Coronary Circulation; Coronary Disease; In Vitro Techniques; I | 1979 |
[Geriatrics].
Topics: Aged; Aging; Anabolic Agents; Humans; Pharmacology; Procaine; Trace Elements; Vitamins | 1977 |
A look at Gerovital--the "youth" drug.
Topics: Age Factors; Aged; Aging; Animals; Depression; Female; Humans; Male; Mice; Middle Aged; Monoamine Ox | 1976 |
[Age changes in the allosteric properties of brain acetylcholinesterase].
Topics: Aging; Animals; Brain; Cholinesterase Inhibitors; In Vitro Techniques; Procaine; Rats; Tubocurarine | 1976 |
[Letter: Gerovital].
Topics: Aging; Anaphylaxis; Procaine | 1975 |
Induction of RSA-like oscillations in both the in-vitro and in-vivo hippocampus.
Topics: Aging; Animals; Carbachol; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Picrot | 1991 |
[Gerovital H3 and Aslavital].
Topics: Aged; Aging; Humans; Middle Aged; Procaine | 1985 |
Effect of procaine on ageing.
Topics: Aging; Humans; Procaine | 1973 |
[On the drug therapy of old-age hearing disorders].
Topics: Aged; Aging; Anabolic Agents; Central Nervous System Stimulants; Hearing Disorders; Heparin; Heparin | 1967 |
[Behavior of blood lipid fraction under Turigeran].
Topics: Aged; Aging; Aminobenzoates; Ascorbic Acid; Cholesterol; Female; Humans; Lipid Metabolism; Lipids; M | 1970 |
Effect of membrane stabilizing drugs on mortality in Drosophila melanogaster.
Topics: Adrenal Cortex Hormones; Aging; Analgesics; Animals; Cell Membrane; Central Nervous System Stimulant | 1971 |
[Aging. 2. Consequences of aging].
Topics: Aged; Aging; Antioxidants; Body Temperature; Cold Temperature; Diet; Genetics, Medical; Geriatrics; | 1973 |
Possible rationale for procaine (Gerovital H3) therapy in geriatrics: inhibition of monoamine oxidase.
Topics: Aged; Aging; Amines; Animals; Biological Assay; Brain; Catecholamines; Depression; Female; Humans; I | 1973 |
[Treatment of psychological failure in aging man].
Topics: Aged; Aging; Amino Alcohols; Cerebrovascular Disorders; Drug Combinations; Female; Geriatrics; Hemat | 1972 |
[Drug therapy in geriatrics].
Topics: Aging; Anabolic Agents; Drug Therapy; Heparin; Humans; Hyperlipidemias; Minerals; Nicotinic Acids; P | 1972 |
A preliminary investigation of the effects of procaine solution on the growth of strain L cells.
Topics: Aging; Cell Division; Cell Survival; Humans; L Cells; Procaine | 1971 |
[Preliminary results of clinical trials of a new anti-aging preparation].
Topics: Aged; Aging; Blood Pressure; Cholesterol; Hematoporphyrins; Humans; Magnesium; Phosphates; Porphyrin | 1969 |
[So-called specific treatment of aging].
Topics: Aged; Aging; Cell- and Tissue-Based Therapy; Female; Geriatrics; Gonadal Steroid Hormones; Humans; M | 1969 |
[What can the physician expect from a geriatric drug?].
Topics: Aged; Aging; Drug Therapy; Female; Geriatrics; Humans; Male; Metabolism; Middle Aged; Procaine; Vita | 1967 |
[Immunological studies on the aged. Dynamic aspects of reactivity in antigenic stimuli of the ABO blood group system. Possibilities of therapeutic stimulation of immunological reactivity].
Topics: ABO Blood-Group System; Aged; Aging; Antistreptolysin; Complement System Proteins; Female; Hemolysin | 1968 |
[Treatment of presenile and senile complaints with an oral procaine-hematoporphyrin preparation].
Topics: Aged; Aging; Female; Hematoporphyrins; Humans; Male; Middle Aged; Porphyrins; Procaine | 1968 |
Procaine therapy for senescence and convalescence in large and small animals.
Topics: Aging; Animal Diseases; Animals; Drug Synergism; Hematoporphyrins; Procaine; Rats | 1969 |
[Therapeutic possibilities of the control of aging processes].
Topics: Aged; Aging; Hematoporphyrins; Humans; Porphyrins; Procaine | 1966 |