procaine has been researched along with Abnormalities, Drug-Induced in 3 studies
Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Embryo-lethal and teratogenic effects caused by the cisplatin-procaine complex cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N(4)]-chlorideplatinum(II) monohydrochloride monohydrate (DPR) were examined in CD-1 mice after a single administration of 7, 14, 21 or 28 mg/kg, injected on day 6, 9, 13 or 16 of pregnancy." | 3.72 | Embryo-lethal and teratogenic effect of the new platinum compound DPR in pregnant mice. ( Lapide, M; Mandys, V; Ognio, E; Ottone, M; Parodi, B; Peterka, M; Viale, M, 2003) |
| " To reduce its toxic side effects in patients, cisplatin has been bound with procaine in a cisplatin-procaine complex (DPR)." | 1.31 | Embryotoxicity of cisplatin and a cisplatin-procaine complex (DPR) studied in chick embryo. ( Cafaggi, S; Esposito, M; Mandys, V; Peterka, M; Peterková, R; Viale, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peterka, M | 2 |
| Mandys, V | 2 |
| Viale, M | 3 |
| Cafaggi, S | 1 |
| Peterková, R | 1 |
| Esposito, M | 1 |
| Ognio, E | 2 |
| Lapide, M | 2 |
| Ottone, M | 1 |
| Parodi, B | 1 |
| Chiavarina, B | 1 |
| Caviglioli, G | 1 |
3 other studies available for procaine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Embryotoxicity of cisplatin and a cisplatin-procaine complex (DPR) studied in chick embryo.
Topics: Abnormalities, Drug-Induced; Anesthetics, Local; Animals; Antineoplastic Agents; Chick Embryo; Cispl | 2002 |
Embryo-lethal and teratogenic effect of the new platinum compound DPR in pregnant mice.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Bone and Bones; Cisplatin; Dose-Respons | 2003 |
Transplacental passage of Pt after treatment with the new triamine complex cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N4]-chloride platinum (II) monohydrochloride monohydrate.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Cisplatin; Embryo, Mammalian; Female; F | 2004 |