Page last updated: 2024-11-03

procaine and Abnormalities, Drug-Induced

procaine has been researched along with Abnormalities, Drug-Induced in 3 studies

Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.

Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

Research Excerpts

ExcerptRelevanceReference
"Embryo-lethal and teratogenic effects caused by the cisplatin-procaine complex cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N(4)]-chlorideplatinum(II) monohydrochloride monohydrate (DPR) were examined in CD-1 mice after a single administration of 7, 14, 21 or 28 mg/kg, injected on day 6, 9, 13 or 16 of pregnancy."3.72Embryo-lethal and teratogenic effect of the new platinum compound DPR in pregnant mice. ( Lapide, M; Mandys, V; Ognio, E; Ottone, M; Parodi, B; Peterka, M; Viale, M, 2003)
" To reduce its toxic side effects in patients, cisplatin has been bound with procaine in a cisplatin-procaine complex (DPR)."1.31Embryotoxicity of cisplatin and a cisplatin-procaine complex (DPR) studied in chick embryo. ( Cafaggi, S; Esposito, M; Mandys, V; Peterka, M; Peterková, R; Viale, M, 2002)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Peterka, M2
Mandys, V2
Viale, M3
Cafaggi, S1
Peterková, R1
Esposito, M1
Ognio, E2
Lapide, M2
Ottone, M1
Parodi, B1
Chiavarina, B1
Caviglioli, G1

Other Studies

3 other studies available for procaine and Abnormalities, Drug-Induced

ArticleYear
Embryotoxicity of cisplatin and a cisplatin-procaine complex (DPR) studied in chick embryo.
    Neoplasma, 2002, Volume: 49, Issue:6

    Topics: Abnormalities, Drug-Induced; Anesthetics, Local; Animals; Antineoplastic Agents; Chick Embryo; Cispl

2002
Embryo-lethal and teratogenic effect of the new platinum compound DPR in pregnant mice.
    Archives of toxicology, 2003, Volume: 77, Issue:10

    Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Bone and Bones; Cisplatin; Dose-Respons

2003
Transplacental passage of Pt after treatment with the new triamine complex cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N4]-chloride platinum (II) monohydrochloride monohydrate.
    Archives of toxicology, 2004, Volume: 78, Issue:10

    Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Cisplatin; Embryo, Mammalian; Female; F

2004