procainamide has been researched along with Muscle Contraction in 45 studies
Procainamide: A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.
procainamide : A benzamide that is 4-aminobenzamide substituted on the amide N by a 2-(diethylamino)ethyl group. It is a pharmaceutical antiarrhythmic agent used for the medical treatment of cardiac arrhythmias.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ten patients with myotonic dystrophy were allocated at random to treatment with disopyramide and procainamide in a cross-over trial." | 9.05 | A comparative study of disopyramide and procainamide in the treatment of myotonia in myotonic dystrophy. ( Finlay, M, 1982) |
| "Amitriptyline, a tricyclic antidepressant, has been reported to diminish signs of human myotonic muscular dystrophy, but has not been examined in other myotonias." | 7.68 | Lack of effect of amitriptyline in murine myotonia. ( Carter, GT; Entrikin, RK; Longley, KJ; Walsh, SA, 1992) |
| "Ten patients with myotonic dystrophy were allocated at random to treatment with disopyramide and procainamide in a cross-over trial." | 5.05 | A comparative study of disopyramide and procainamide in the treatment of myotonia in myotonic dystrophy. ( Finlay, M, 1982) |
| "Amitriptyline, a tricyclic antidepressant, has been reported to diminish signs of human myotonic muscular dystrophy, but has not been examined in other myotonias." | 3.68 | Lack of effect of amitriptyline in murine myotonia. ( Carter, GT; Entrikin, RK; Longley, KJ; Walsh, SA, 1992) |
| "Malignant hyperpyrexia is a genetically related syndrome that cannot be predicted reliably in advance of administration of anesthesia except by a strong family history." | 2.36 | Malignant hyperpyrexia. ( Stephen, CR, 1977) |
| "Pretreatment with propranolol (0." | 1.27 | The inotropic actions of N-acetylprocainamide: blockade and reversal by propranolol. ( Donkor, KA; King, LW; Lertora, JJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (88.89) | 18.7374 |
| 1990's | 3 (6.67) | 18.2507 |
| 2000's | 2 (4.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stout, DM | 1 |
| Matier, WL | 1 |
| Barcelon-Yang, C | 1 |
| Reynolds, RD | 1 |
| Brown, BS | 1 |
| ALLARD, JR | 1 |
| WARE, WH | 1 |
| BENNETT, LL | 1 |
| Maeda, K | 1 |
| Courtney, KR | 1 |
| Finlay, M | 1 |
| Nakahara, T | 2 |
| Moriuchi, H | 2 |
| Yunoki, M | 2 |
| Kubota, Y | 2 |
| Tanaka, Y | 2 |
| Sakamato, K | 2 |
| Shigenobu, K | 2 |
| Ishii, K | 2 |
| Coccagna, G | 1 |
| Mantovani, M | 1 |
| Parchi, C | 1 |
| Mironi, F | 1 |
| Lugaresi, E | 1 |
| Stephen, CR | 1 |
| Nelson, TE | 1 |
| Flewellen, EH | 1 |
| Carter, GT | 1 |
| Longley, KJ | 1 |
| Walsh, SA | 1 |
| Entrikin, RK | 1 |
| Yeh, TM | 1 |
| Tami, JA | 1 |
| Krolick, KA | 1 |
| Lehmann-Horn, F | 1 |
| Iaizzo, PA | 1 |
| Franke, C | 1 |
| Hatt, H | 1 |
| Spaans, F | 1 |
| Lertora, JJ | 1 |
| King, LW | 1 |
| Donkor, KA | 1 |
| Strobel, GE | 2 |
| Ricker, K | 1 |
| Meinch, HM | 1 |
| Stumpf, H | 1 |
| Heeg, E | 3 |
| Reuter, N | 2 |
| Steiger, H | 1 |
| Mason, DT | 1 |
| Zelis, R | 1 |
| Lee, G | 1 |
| Hughes, JL | 1 |
| Spann, JF | 1 |
| Amsterdam, EA | 1 |
| Zetler, G | 1 |
| Strubelt, O | 1 |
| Senges, J | 1 |
| Rüdel, R | 1 |
| Kuhn, E | 1 |
| Jacque, M | 1 |
| Luchi, RJ | 1 |
| Kritcher, EM | 1 |
| Lundberg, PO | 1 |
| Stålberg, E | 1 |
| Thiele, B | 1 |
| Benfey, BG | 1 |
| Greeff, K | 2 |
| Giuliano, H | 1 |
| Smirnov, AI | 1 |
| Graham, JD | 1 |
| Chandler, BM | 1 |
| Shore, RN | 1 |
| MacLachlan, TB | 1 |
| Negri, S | 1 |
| Bianchi, CP | 1 |
| Nahas, M | 1 |
| Lachapelle, J | 1 |
| Tremblay, GM | 1 |
| Tinker, J | 1 |
| Cox, AG | 1 |
| Bruno, L | 1 |
| Giani, P | 1 |
| Bellinvia, P | 1 |
| Yung, DK | 2 |
| Vohra, MM | 1 |
| Chu, I | 1 |
| Heitmann, P | 1 |
| Möller, N | 1 |
| Murnaghan, MF | 1 |
| Johnson, WE | 1 |
| Graeff, DM | 1 |
| Martin, AR | 1 |
| White, AI | 1 |
| Harrah, MD | 1 |
| Way, WL | 1 |
| Katzung, BG | 1 |
| Robelli, F | 1 |
| De Vita, C | 1 |
| Cadel, A | 1 |
| Chatten, LG | 1 |
| MacLeod, DP | 1 |
| Bertaccini, G | 1 |
| Impicciatore, M | 1 |
| Visioli, O | 1 |
| Malagnino, G | 1 |
| Molinengo, L | 1 |
| Büchi, J | 1 |
| Fischer, G | 1 |
| Mohs, M | 1 |
| Perlia, X | 1 |
2 reviews available for procainamide and Muscle Contraction
| Article | Year |
|---|---|
Malignant hyperpyrexia.
Topics: Acute Kidney Injury; Adenosine Triphosphate; Anesthetics; Bicarbonates; Body Temperature; Calcium; C | 1977 |
Current concepts and treatment of digitalis toxicity.
Topics: Adenosine Triphosphatases; Arrhythmias, Cardiac; Binding Sites; Biological Transport; Calcium; Catec | 1971 |
1 trial available for procainamide and Muscle Contraction
| Article | Year |
|---|---|
A comparative study of disopyramide and procainamide in the treatment of myotonia in myotonic dystrophy.
Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Disopyramide; Female; Humans; | 1982 |
42 other studies available for procainamide and Muscle Contraction
| Article | Year |
|---|---|
Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 2. Amides.
Topics: Amides; Animals; Anti-Arrhythmia Agents; Chemical Phenomena; Chemistry; Dogs; Electric Stimulation; | 1984 |
Negative chronotropism and inotropism of procaine amide in the heart.
Topics: Heart; Humans; Muscle Contraction; Procainamide | 1960 |
[Effects of ouabain on the isolated guinea-pig atria pretreated by reserpine and under the influence of propranolol administration].
Topics: Animals; Arrhythmias, Cardiac; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Muscle Con | 1967 |
Depressant effects of drugs used in myotonia therapy.
Topics: Animals; In Vitro Techniques; Ion Channels; Lidocaine; Mexiletine; Muscle Contraction; Myotonia; Phe | 1982 |
Involvement of K(+) channel in procainamide-induced relaxation of bovine tracheal smooth muscle.
Topics: Albuterol; Animals; Anti-Arrhythmia Agents; Bronchoconstrictor Agents; Bronchodilator Agents; Cattle | 2000 |
Role of K+ channels in N-acetylprocainamide-induced relaxation of bovine tracheal smooth muscle.
Topics: Acecainide; Animals; Barium; Cattle; Dose-Response Relationship, Drug; In Vitro Techniques; Methacho | 2001 |
Alveolar hypoventilation and hyperosmnia in myotonic dystrophy.
Topics: Aminobutyrates; Disorders of Excessive Somnolence; Humans; Hypoventilation; Male; Middle Aged; Muscl | 1975 |
Rationale for dantrolene vs. procainamide for treatment of malignant hyperthermia.
Topics: Animals; Dantrolene; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Halothane; Hy | 1979 |
Lack of effect of amitriptyline in murine myotonia.
Topics: Amitriptyline; Animals; Behavior, Animal; Electromyography; Mice; Mice, Inbred Strains; Muscle Contr | 1992 |
Exacerbated muscle dysfunction by procainamide in rats with experimental myasthenia gravis.
Topics: Animals; Antibodies; Autoimmune Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; | 1992 |
Schwartz-Jampel syndrome: II. Na+ channel defect causes myotonia.
Topics: Child, Preschool; Curare; Electromyography; Humans; Male; Muscle Contraction; Muscles; Myotonia; Ost | 1990 |
The inotropic actions of N-acetylprocainamide: blockade and reversal by propranolol.
Topics: Acecainide; Animals; Atropine; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Heart Rate; M | 1986 |
Treatment of anaesthetic-induced malignant hyperpyrexia.
Topics: Anesthesia, Local; Anesthetics; Calcium; Fever; Humans; Lidocaine; Muscle Contraction; Procainamide | 1971 |
[Neurophysiological studies on the temporary paresis in myotonia congenita and dystrophia myotonica].
Topics: Action Potentials; Adult; Cell Membrane; Female; Guanidines; Humans; Magnesium; Male; Middle Aged; M | 1973 |
[Influence of active antiarrhythmia substances on refractory period and contractility of guinea pig atria].
Topics: Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; Heart Atria; In Vitro Techniques; Lidocaine; Mu | 1969 |
Actions of antiarrhythmic drugs on refractory period and contractility of isolated rat and guinea-pig atria.
Topics: Ajmaline; Animals; Anti-Arrhythmia Agents; Ethers; Ethylamines; Glycerol; Guinea Pigs; Heart Atria; | 1971 |
Effects of quinidine, procaine amide, and N-propyl-ajmaline on skeletal muscle.
Topics: Action Potentials; Ajmaline; Animals; Diaphragm; In Vitro Techniques; Membrane Potentials; Muscle Co | 1973 |
[Effect of hypothermia on the action of procaine amide at the level of the isolated rat diaphragm].
Topics: Animals; Diaphragm; Electric Stimulation; Hypothermia, Induced; In Vitro Techniques; Ion Exchange; M | 1974 |
Drug effects on cardiac myosin adenosine triphosphatase activity.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Angiotensin II; Animals; Binding Sites; Calcium; | 1967 |
Paralysis periodica paramyotonica. A clinical and neurophysiological study.
Topics: Acetazolamide; Acetylcholine; Adult; Alanine Transaminase; Aspartate Aminotransferases; Calcium; Cre | 1974 |
Evaluation of sympathetic beta-receptor blockade by recording the rate of ventricular pressure rise in cats.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cats; Drug Antagonism; Ethanolamines; Heart Rate; H | 1967 |
A comparison of the cardiac activity of a new antiarrhythmic drug--pipazetate--with quinidine, procainamide, antazoline and diphenylhydantoin.
Topics: Animals; Anti-Arrhythmia Agents; Antitussive Agents; Atrial Function; Depression, Chemical; Dogs; He | 1970 |
[Action of antiarrhythmic and -receptor blocking drugs on functional refractory period and contractility of electrically stimulated guinea-pig atria].
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Anti-Arrhythmia Agents; Atrial Function; Drug Inte | 1971 |
Automatic contractions of the specific ventricular muscle of the isolated rabbit heart.
Topics: Acetylcholine; Animals; Caffeine; Calcium Chloride; Depression, Chemical; Electrophysiology; Epineph | 1974 |
The effects of lidocaine, propranolol, procaine amide, and bretylium tosylate on the contractility of isolated cat papillary muscles.
Topics: Animals; Bretylium Compounds; Cats; Depression, Chemical; Dose-Response Relationship, Drug; Electric | 1973 |
Pregnancy with myotonic dystrophy: course, complications and management.
Topics: Abortion, Habitual; Adult; Contraception; Electromyography; Female; Fetal Death; Hemorrhage; Humans; | 1971 |
An atypical case of Steinert's disease (myotonia dystrophica) in infancy.
Topics: Age Factors; Child; Creatine Kinase; Electroencephalography; Electromyography; Facial Muscles; Femal | 1971 |
An in-vitro model of anesthetic hypertonic hyperpyrexia, halothane--caffeine-induced muscle contractures: prevention of contracture by procainamide.
Topics: Anesthesia, Inhalation; Animals; Anura; Caffeine; Culture Techniques; Drug Synergism; Fever; Halotha | 1971 |
Comparative effect of procainamide and lidocaine on myocardial contractility.
Topics: Animals; Heart; Heart Ventricles; Lidocaine; Muscle Contraction; Perfusion; Pressure; Procainamide; | 1969 |
Effect of metoclopramide on transport in the small intestine of the dog.
Topics: Animals; Biological Transport; Coloring Agents; Dogs; Gastrointestinal Agents; Gastrointestinal Moti | 1969 |
[Pharmacological and toxicological side effects of antifibrillatory substances].
Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Autonomic Nervous System; Cell Membrane Permeability | 1969 |
[Modifications of the inotropic effect of ajmalin in a healthy subject. Comparison of the quinidine and procainamide effect].
Topics: Adult; Ajmaline; Anti-Arrhythmia Agents; Heart; Heart Function Tests; Heart Rate; Humans; Male; Musc | 1969 |
Potential antiarrhythmic agents. II. Effects of amide reversal and ortho-methylation on activity of procaine amide.
Topics: Aconitum; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Chemical Phenomena; Chemistry | 1970 |
The effect of metoclopramide on the gastroesophageal junctional zone and the distal esophagus in man.
Topics: Adult; Aged; Esophagogastric Junction; Esophagus; Female; Gastrointestinal Motility; Humans; Injecti | 1970 |
Comparative effectiveness of lignocaine, quinidine, propranolol and procainamide as antifibrillatory agents.
Topics: Animals; Depression, Chemical; Electric Stimulation; Heart; Heart Rate; In Vitro Techniques; Lidocai | 1970 |
A new myocardial depressant and antifibrillatory agent.
Topics: Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; Heart Atria; Heart Rate; In Vitro Techniques; L | 1970 |
The interaction of d-tubocurarine with antiarrhythmic drugs.
Topics: Animals; Anti-Arrhythmia Agents; Cats; Drug Synergism; Electric Stimulation; Lidocaine; Muscle Contr | 1970 |
[Therapy of acute myocardial infarct with particular reference to arrhythmia and myocardial contractibility disorders].
Topics: Adult; Aged; Aging; Arrhythmias, Cardiac; Atropine; Cardiac Glycosides; Cortisone; Electric Counters | 1971 |
Potential antiarrhythmic agents. I. Synthesis and pharmacological evaluation of some piperazine and ethylenediamine analogs of procaine amide.
Topics: Aconitum; Animals; Arrhythmias, Cardiac; Cats; Epinephrine; Ethers; Ethylenediamines; Guinea Pigs; H | 1968 |
Effects of interaction of antiarrhythmic drugs and beta-blocking agents on the isolated rabbit heart.
Topics: Amino Alcohols; Animals; Anti-Arrhythmia Agents; Drug Antagonism; Electrocardiography; Female; Heart | 1968 |
On the pharmacological inhibition of epinephrine-induced ventricular automaticity.
Topics: Acetanilides; Acetylcholine; Animals; Atropine; Benzoates; Emetine; Ephedrine; Epinephrine; Heart; H | 1968 |
[Relations between physical-chemical properties, chemical reactivity and local anesthetic effect in some procaine analogues. (Change of the carboxyl-group). 26].
Topics: Adsorption; Anesthetics, Local; Animals; Anura; Chemical Phenomena; Chemistry; Chemistry, Physical; | 1969 |