Compounds > procainamide
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procainamide and Agranulocytosis

procainamide has been researched along with Agranulocytosis in 42 studies

Procainamide: A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.
procainamide : A benzamide that is 4-aminobenzamide substituted on the amide N by a 2-(diethylamino)ethyl group. It is a pharmaceutical antiarrhythmic agent used for the medical treatment of cardiac arrhythmias.

Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).

Research Excerpts

ExcerptRelevanceReference
"A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide (750 mg/day)."7.69Sustained-release procainamide-induced reversible granulocytopenia after myocardial infarction. ( Abe, H; Kuroiwa, A; Suzuka, H; Tasaki, H, 1995)
"Agranulocytosis is a well recognized but uncommon complication of procainamide (PA) therapy, whereas a lupus-like syndrome occurs in approximately 20% of patients treated chronically with PA."7.69Procainamide-induced agranulocytosis differs serologically and clinically from procainamide-induced lupus. ( Creamer, JI; Kenyon, CM; Rubin, RL; Simrell, CR; Starkebaum, G, 1996)
"A 56-year-old man developed procainamide-induced agranulocytosis."7.67Procainamide-induced agranulocytosis with reversible myeloid sensitivity. ( Fass, AE; Lutton, JD; Nelson, JC, 1984)
"We have described six new patients accounting for seven episodes of agranulocytosis due to procainamide."7.67Procainamide-induced agranulocytosis. ( Reidy, TJ; Upshaw, JD, 1984)
"Neutropenia is a rare complication of procainamide therapy."7.67Severe neutropenia associated with sustained-release procainamide. ( Ellrodt, AG; Gray, R; Mochizuki, C; Murata, GH; Riedinger, MS; Stewart, ME, 1984)
"With increased use of sustained-release forms of procainamide in treating common cardiac arrhythmias, more and more cases of severe neutropenia and occasional deaths have been reported."7.67Severe neutropenia due to sustained-release procainamide. ( Hoyt, RE, 1987)
"Procainamide therapy has frequently been reported as a cause of agranulocytosis, but severe thrombocytopenia associated with the use of this drug has been noted only once."7.66Procainamide-induced agranulocytosis and thrombocytopenia. ( Amorosi, EL; Rothman, IK, 1979)
"Bone marrow granulomas and neutropenia occurred in a 77-year-old man following the ingestion of procainamide hydrochloride for 50 days."7.66Bone marrow granulomas and neutropenia associated with procainamide. Report of a case. ( Baker, J; Riker, J; Swanson, M, 1978)
"The case of a 69-year-old woman with procainamide-induced agranulocytosis is reported, and literature reports of 14 other such cases are reviewed."7.65Agranulocytosis associated with procainamide therapy--report of a case. ( Brown, BT; Jacknowitz, AI; Prince, RA, 1977)
"A 73-year-old woman was found to have clinically significant pancytopenia in association with procainamide hydrochloride ingestion."7.65Severe transient pancytopenia associated with procainamide ingestion. ( Bluming, AZ; Plotkin, D; Rosen, P; Thiessen, AR, 1976)
"We have presented two cases of agranulocytosis occurring in patients receiving a combination antiarrhythmic regimen."5.26Agranulocytosis during combined procainamide and phenytoin therapy. ( Crook, JE; Leftwich, RB; Natelson, EA; Woosley, RL, 1979)
"A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide (750 mg/day)."3.69Sustained-release procainamide-induced reversible granulocytopenia after myocardial infarction. ( Abe, H; Kuroiwa, A; Suzuka, H; Tasaki, H, 1995)
"Neutropenia is a rare complication of procainamide therapy."3.67Severe neutropenia associated with sustained-release procainamide. ( Ellrodt, AG; Gray, R; Mochizuki, C; Murata, GH; Riedinger, MS; Stewart, ME, 1984)
"With increased use of sustained-release forms of procainamide in treating common cardiac arrhythmias, more and more cases of severe neutropenia and occasional deaths have been reported."3.67Severe neutropenia due to sustained-release procainamide. ( Hoyt, RE, 1987)
"Procainamide therapy has frequently been reported as a cause of agranulocytosis, but severe thrombocytopenia associated with the use of this drug has been noted only once."3.66Procainamide-induced agranulocytosis and thrombocytopenia. ( Amorosi, EL; Rothman, IK, 1979)
"Bone marrow granulomas and neutropenia occurred in a 77-year-old man following the ingestion of procainamide hydrochloride for 50 days."3.66Bone marrow granulomas and neutropenia associated with procainamide. Report of a case. ( Baker, J; Riker, J; Swanson, M, 1978)
"The case of a 69-year-old woman with procainamide-induced agranulocytosis is reported, and literature reports of 14 other such cases are reviewed."3.65Agranulocytosis associated with procainamide therapy--report of a case. ( Brown, BT; Jacknowitz, AI; Prince, RA, 1977)
"A 73-year-old woman was found to have clinically significant pancytopenia in association with procainamide hydrochloride ingestion."3.65Severe transient pancytopenia associated with procainamide ingestion. ( Bluming, AZ; Plotkin, D; Rosen, P; Thiessen, AR, 1976)
"We have presented two cases of agranulocytosis occurring in patients receiving a combination antiarrhythmic regimen."1.26Agranulocytosis during combined procainamide and phenytoin therapy. ( Crook, JE; Leftwich, RB; Natelson, EA; Woosley, RL, 1979)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199039 (92.86)18.7374
1990's3 (7.14)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
FABREGOULE, M1
MESSERSCHMITT, J1
TALMERS, FN1
TELMOS, AJ1
INOUYE, M1
MILLAR, J1
TOWNSEND, JH1
Azócar, J1
Nagesh, KG1
Poulose, KP1
Tseng, TH1
Schadchehr, A1
Woosley, RL2
Roden, DM1
Nelson, JC1
Lutton, JD1
Fass, AE1
Anderson, S1
Wenger, NK1
Reidy, TJ1
Upshaw, JD1
Clary, RM1
Beazley, WS1
Henley, RW1
Ellrodt, AG2
Murata, GH1
Riedinger, MS1
Stewart, ME1
Mochizuki, C1
Gray, R1
Fleet, S1
Christensen, DJ1
Palma, LF1
Phelps, K1
Berger, BE1
Hauser, DJ1
Rollag, A1
Knipping, W1
Abe, H1
Suzuka, H1
Tasaki, H1
Kuroiwa, A1
Starkebaum, G1
Kenyon, CM1
Simrell, CR1
Creamer, JI1
Rubin, RL1
Rothman, IK1
Amorosi, EL1
Crook, JE1
Leftwich, RB1
Natelson, EA1
Prince, RA1
Brown, BT1
Jacknowitz, AI1
van Beek, RJ1
Bieger, R1
den Ottolander, GJ1
Riker, J1
Baker, J1
Swanson, M1
Bluming, AZ1
Plotkin, D1
Rosen, P1
Thiessen, AR1
Chelius, CJ1
Nunag, AN1
Hoffman, HS1
Freed, JS1
Reiner, MA1
Malters, PB1
Salem, AG1
Hoyt, RE1
Kimmel, DP1
Antignano, LV1
Barold, SS1
Boros, L2
Olson, JP1
Meyers, DG1
Gonzalez, ER1
Peters, LL1
Davis, RB1
Feagler, JR1
Egan, JD1
Nair, CK1
Katkov, W1
Konttinen, YP2
Tuominen, L2
Golochevskaia, VS1
Hensen, A1
Gunay, U1
Honig, GR1
Hickson, B1
Davidson, RJ1
Walker, W1
Ream, CR1
Barrera, R1
Wang, RI1
Schuller, G1

Reviews

2 reviews available for procainamide and Agranulocytosis

ArticleYear
Septic complications of procainamide-induced agranulocytosis: report of two cases.
    The Mount Sinai journal of medicine, New York, 1988, Volume: 55, Issue:2

    Topics: Aged; Agranulocytosis; Escherichia coli Infections; Female; Humans; Male; Procainamide; Pseudomonas

1988
[Side effects of anti-arrhythmic agents].
    Klinicheskaia meditsina, 1971, Volume: 49, Issue:10

    Topics: 1-Propanol; Adrenal Cortex Hormones; Agranulocytosis; Anorexia Nervosa; Anti-Arrhythmia Agents; Anti

1971

Other Studies

40 other studies available for procainamide and Agranulocytosis

ArticleYear
[Agranulocytosis during procaine amide treatment].
    Le Sang, 1954, Volume: 25, Issue:5

    Topics: Agranulocytosis; Humans; Procainamide

1954
A CASE REPORT: PROCAINE AMIDE HYDROCHLORIDE (PRONESTYL) INDUCED AGRANULOCYTOSIS.
    Michigan medicine, 1965, Volume: 64

    Topics: Agranulocytosis; Drug Therapy; Geriatrics; Humans; Procainamide; Toxicology; Ventricular Fibrillatio

1965
Agranulocytosis following maintenance dosage of pronestyl; report of severe case with recovery.
    Journal of the American Medical Association, 1951, Oct-13, Volume: 147, Issue:7

    Topics: Agranulocytosis; Biological Phenomena; Physiological Phenomena; Procainamide; Procaine

1951
Anti-myeloid-cell antibody in procainamide-induced agranulocytosis.
    Lancet (London, England), 1984, May-12, Volume: 1, Issue:8385

    Topics: Aged; Agranulocytosis; Autoantibodies; Bone Marrow; Humans; Male; Middle Aged; Procainamide

1984
Procainamide-induced agranulocytosis: report of two cases and review.
    The Journal of the Kansas Medical Society, 1980, Volume: 81, Issue:1

    Topics: Aged; Agranulocytosis; Cardiac Complexes, Premature; Child; Female; Heart Ventricles; Humans; Male;

1980
Importance of metabolites in antiarrhythmic therapy.
    The American journal of cardiology, 1983, Sep-22, Volume: 52, Issue:6

    Topics: Acecainide; Agranulocytosis; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Encainide; Huma

1983
Procainamide-induced agranulocytosis with reversible myeloid sensitivity.
    American journal of hematology, 1984, Volume: 17, Issue:4

    Topics: Agranulocytosis; Bone Marrow; Colony-Forming Units Assay; Colony-Stimulating Factors; Granulocytes;

1984
Sustained-release procainamide and neutropenia.
    Annals of internal medicine, 1984, Volume: 101, Issue:3

    Topics: Agranulocytosis; Delayed-Action Preparations; Humans; Neutropenia; Procainamide

1984
Procainamide-induced agranulocytosis.
    Southern medical journal, 1984, Volume: 77, Issue:12

    Topics: Administration, Oral; Aged; Agranulocytosis; Delayed-Action Preparations; Female; Humans; Male; Midd

1984
Fatal typhlitis secondary to procainamide-induced agranulocytosis.
    Virginia medical, 1984, Volume: 111, Issue:11

    Topics: Aged; Agranulocytosis; Cecal Diseases; Female; Humans; Inflammation; Procainamide

1984
Severe neutropenia associated with sustained-release procainamide.
    Annals of internal medicine, 1984, Volume: 100, Issue:2

    Topics: Aged; Agranulocytosis; Benzothiadiazines; Cardiac Surgical Procedures; Delayed-Action Preparations;

1984
Agranulocytosis, procainamide, and phenytoin.
    Annals of internal medicine, 1984, Volume: 100, Issue:4

    Topics: Aged; Agranulocytosis; Humans; Male; Phenytoin; Procainamide

1984
Procainamide and neutropenia.
    Annals of internal medicine, 1984, Volume: 100, Issue:5

    Topics: Aged; Agranulocytosis; Delayed-Action Preparations; Humans; Male; Neutropenia; Procainamide

1984
Agranulocytosis, thrombocytopenia, and procainamide.
    Annals of internal medicine, 1984, Volume: 100, Issue:6

    Topics: Aged; Agranulocytosis; Delayed-Action Preparations; Female; Humans; Male; Procainamide; Thrombocytop

1984
Agranulocytosis due to new sustained-release procainamide.
    American heart journal, 1983, Volume: 105, Issue:6

    Topics: Administration, Oral; Aged; Agranulocytosis; Arrhythmias, Cardiac; Delayed-Action Preparations; Huma

1983
[Procainamide induced agranulocytosis].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1982, Jan-20, Volume: 102, Issue:2

    Topics: Aged; Agranulocytosis; Humans; Male; Procainamide

1982
[Problems of evaluating rare adverse drug reactions using as an example agranulocytosis induced by anti-arrhythmia agents].
    Medizinische Klinik, 1980, Feb-01, Volume: 75, Issue:3

    Topics: Aged; Agranulocytosis; Ajmaline; Anti-Arrhythmia Agents; Drug Therapy, Combination; Drug-Related Sid

1980
Sustained-release procainamide-induced reversible granulocytopenia after myocardial infarction.
    Japanese heart journal, 1995, Volume: 36, Issue:4

    Topics: Aged; Agranulocytosis; Anti-Arrhythmia Agents; Atrial Fibrillation; Blood Cell Count; Delayed-Action

1995
Procainamide-induced agranulocytosis differs serologically and clinically from procainamide-induced lupus.
    Clinical immunology and immunopathology, 1996, Volume: 78, Issue:2

    Topics: Aged; Aged, 80 and over; Agranulocytosis; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Antinu

1996
Procainamide-induced agranulocytosis and thrombocytopenia.
    Archives of internal medicine, 1979, Volume: 139, Issue:2

    Topics: Aged; Agranulocytosis; Arteriosclerosis; Humans; Male; Procainamide; Thrombocytopenia

1979
Agranulocytosis during combined procainamide and phenytoin therapy.
    Southern medical journal, 1979, Volume: 72, Issue:12

    Topics: Acetylation; Acetyltransferases; Aged; Agranulocytosis; Arrhythmias, Cardiac; Drug Therapy, Combinat

1979
Agranulocytosis associated with procainamide therapy--report of a case.
    American journal of hospital pharmacy, 1977, Volume: 34, Issue:12

    Topics: Aged; Agranulocytosis; Arrhythmias, Cardiac; Female; Humans; Leukocyte Count; Procainamide; Time Fac

1977
Reversible severe anaemia and granulocytopenia caused by procainamide. A case report.
    Scandinavian journal of haematology, 1978, Volume: 21, Issue:2

    Topics: Agranulocytosis; Anemia; Humans; Male; Middle Aged; Procainamide

1978
Bone marrow granulomas and neutropenia associated with procainamide. Report of a case.
    Archives of internal medicine, 1978, Volume: 138, Issue:11

    Topics: Aged; Agranulocytosis; Bone Marrow Diseases; Granuloma; Humans; Male; Neutropenia; Procainamide

1978
Severe transient pancytopenia associated with procainamide ingestion.
    JAMA, 1976, Nov-29, Volume: 236, Issue:22

    Topics: Aged; Agranulocytosis; Female; Humans; Myocardial Infarction; Pancytopenia; Procainamide

1976
Procainamide reactions.
    Wisconsin medical journal, 1975, Volume: 74, Issue:1

    Topics: Aged; Agranulocytosis; Drug Hypersensitivity; Humans; Male; Middle Aged; Procainamide; Respiratory T

1975
Severe neutropenia with procainamide therapy.
    Connecticut medicine, 1990, Volume: 54, Issue:2

    Topics: Aged; Agranulocytosis; Humans; Male; Neutropenia; Procainamide

1990
Agranulocytosis secondary to extended-release procainamide: a case report and review of the literature. A case of agranulocytosis caused by procainamide in a patient who had undergone open-heart surgery.
    South Dakota journal of medicine, 1987, Volume: 40, Issue:2

    Topics: Agranulocytosis; Angina Pectoris; Angina, Unstable; Delayed-Action Preparations; Humans; Male; Middl

1987
Severe neutropenia due to sustained-release procainamide.
    Southern medical journal, 1987, Volume: 80, Issue:9

    Topics: Aged; Agranulocytosis; Delayed-Action Preparations; Humans; Male; Neutropenia; Procainamide; Tachyca

1987
Neutropenia associated with procainamide.
    New York state journal of medicine, 1985, Volume: 85, Issue:5

    Topics: Aged; Agranulocytosis; Female; Heart Diseases; Humans; Male; Neutropenia; Procainamide

1985
Correction: procainamide versus Procan SR.
    New York state journal of medicine, 1985, Volume: 85, Issue:10

    Topics: Agranulocytosis; Humans; Neutropenia; Procainamide

1985
Severe neutropenia associated with procainamide: comparison of sustained release and conventional preparations.
    American heart journal, 1985, Volume: 109, Issue:6

    Topics: Aged; Agranulocytosis; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Neutropenia;

1985
Neutropenia and procainamide.
    American heart journal, 1985, Volume: 110, Issue:6

    Topics: Agranulocytosis; Humans; Neutropenia; Procainamide

1985
Reversible procainamide-induced agranulocytosis twice in one patient.
    Lancet (London, England), 1971, Oct-23, Volume: 2, Issue:7730

    Topics: Adenocarcinoma; Aged; Agranulocytosis; Coronary Disease; Female; Heart Neoplasms; Humans; Myocardial

1971
[Agranulocytosis caused by procainamide (Pronestyl)].
    Nederlands tijdschrift voor geneeskunde, 1974, Apr-27, Volume: 118, Issue:17

    Topics: Aged; Agranulocytosis; Angina Pectoris; Cardiac Complexes, Premature; Female; Humans; Procainamide

1974
Agranulocytosis in a 12-year-old girl treated with procainamide.
    Clinical pediatrics, 1974, Volume: 13, Issue:9

    Topics: Agranulocytosis; Arrhythmias, Cardiac; Blood Cell Count; Child; Female; Humans; Procainamide

1974
Agranulocytosis caused by procainamide.
    Scottish medical journal, 1972, Volume: 17, Issue:5

    Topics: Acute Kidney Injury; Aged; Agranulocytosis; Anemia; Antibodies, Antinuclear; Anuria; Erythropoiesis;

1972
[Procaine amide-induced agranulocytosis].
    Duodecim; laaketieteellinen aikakauskirja, 1972, Volume: 88, Issue:10

    Topics: Aged; Agranulocytosis; Creatinine; Female; Humans; Kidney; Procainamide; Ventricular Fibrillation

1972
Desensitization to procainamide.
    The Journal of the Medical Society of New Jersey, 1970, Volume: 67, Issue:3

    Topics: Agranulocytosis; Arrhythmias, Cardiac; Desensitization, Immunologic; Humans; Leukopenia; Male; Methy

1970
Agranulocytosis following procainamide administration.
    American heart journal, 1969, Volume: 78, Issue:2

    Topics: Aged; Agranulocytosis; Blood Cell Count; Bone Marrow Examination; Humans; Male; Procainamide; Tachyc

1969