probucol has been researched along with Pulmonary Fibrosis in 1 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Probucol treatment attenuated bleomycin-induced TGF-β1 production, EMT and pulmonary fibrosis, meanwhile it suppressed bleomycin-induced oxidative stress." | 1.51 | Probucol ameliorates EMT and lung fibrosis through restoration of SIRT3 expression. ( Li, HP; Li, YN; Liu, YJ; Wang, XL; Yang, T; Ye, CL; Zhang, HX; Zhu, XY, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, HX | 1 |
| Li, YN | 1 |
| Wang, XL | 1 |
| Ye, CL | 1 |
| Zhu, XY | 1 |
| Li, HP | 1 |
| Yang, T | 1 |
| Liu, YJ | 1 |
1 other study available for probucol and Pulmonary Fibrosis
| Article | Year |
|---|---|
Probucol ameliorates EMT and lung fibrosis through restoration of SIRT3 expression.
Topics: Actins; Alveolar Epithelial Cells; Animals; Bleomycin; Cadherins; Cell Culture Techniques; Collagen | 2019 |