probucol has been researched along with Osteonecrosis in 4 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Osteonecrosis: Death of a bone or part of a bone, either atraumatic or posttraumatic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Simvastatin and pravastatin significantly reduced the incidence of steroid-induced osteonecrosis in rabbits." | 7.74 | Effect of simvastatin on steroid-induced osteonecrosis evidenced by the serum lipid level and hepatic cytochrome P4503A in a rabbit model. ( Asada, A; Iwaki, H; Iwakiri, K; Kaneshiro, Y; Kobayashi, A; Masada, T; Oda, Y; Takaoka, K, 2008) |
| "We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia." | 4.84 | [Animal models for steroid-induced osteonecrosis]. ( Iwamoto, Y; Miyanishi, K; Motomura, G; Nishida, K; Sueishi, K; Yamamoto, T, 2007) |
| "Simvastatin and pravastatin significantly reduced the incidence of steroid-induced osteonecrosis in rabbits." | 3.74 | Effect of simvastatin on steroid-induced osteonecrosis evidenced by the serum lipid level and hepatic cytochrome P4503A in a rabbit model. ( Asada, A; Iwaki, H; Iwakiri, K; Kaneshiro, Y; Kobayashi, A; Masada, T; Oda, Y; Takaoka, K, 2008) |
| "To investigate the effects of combination treatment with an anticoagulant (warfarin) plus a lipid-lowering agent (probucol) on the prevention of steroid-induced osteonecrosis (ON) in rabbits." | 3.72 | Combined effects of an anticoagulant and a lipid-lowering agent on the prevention of steroid-induced osteonecrosis in rabbits. ( Iwamoto, Y; Jingushi, S; Miyanishi, K; Motomura, G; Yamamoto, T, 2004) |
| "Probucol and warfarin were administered beginning 1 to 2 weeks prior to steroid injection." | 1.35 | Risk factors for developing osteonecrosis after prophylaxis in steroid-treated rabbits. ( Hirota, Y; Iwamoto, Y; Kondo, K; Miyanishi, K; Motomura, G; Yamamoto, T, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iwakiri, K | 1 |
| Oda, Y | 1 |
| Kaneshiro, Y | 1 |
| Iwaki, H | 1 |
| Masada, T | 1 |
| Kobayashi, A | 1 |
| Asada, A | 1 |
| Takaoka, K | 1 |
| Motomura, G | 3 |
| Yamamoto, T | 3 |
| Miyanishi, K | 3 |
| Kondo, K | 1 |
| Hirota, Y | 1 |
| Iwamoto, Y | 3 |
| Jingushi, S | 1 |
| Nishida, K | 1 |
| Sueishi, K | 1 |
1 review available for probucol and Osteonecrosis
| Article | Year |
|---|---|
[Animal models for steroid-induced osteonecrosis].
Topics: Animals; Anticholesteremic Agents; Anticoagulants; Disease Models, Animal; Dose-Response Relationshi | 2007 |
3 other studies available for probucol and Osteonecrosis
| Article | Year |
|---|---|
Effect of simvastatin on steroid-induced osteonecrosis evidenced by the serum lipid level and hepatic cytochrome P4503A in a rabbit model.
Topics: Animals; Cytochrome P-450 CYP3A; Female; Glucocorticoids; Hydroxymethylglutaryl-CoA Reductase Inhibi | 2008 |
Risk factors for developing osteonecrosis after prophylaxis in steroid-treated rabbits.
Topics: Adrenal Cortex Hormones; Animals; Anticholesteremic Agents; Anticoagulants; Biomarkers; Chemoprevent | 2008 |
Combined effects of an anticoagulant and a lipid-lowering agent on the prevention of steroid-induced osteonecrosis in rabbits.
Topics: Adipocytes; Animals; Anticholesteremic Agents; Anticoagulants; Bone Marrow; Drug Therapy, Combinatio | 2004 |