probucol has been researched along with Lecithin Cholesterol Acyltransferase Deficiency in 3 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Lecithin Cholesterol Acyltransferase Deficiency: An autosomal recessive disorder of lipoprotein metabolism caused by mutation of LECITHIN CHOLESTEROL ACYLTRANSFERASE gene. It is characterized by low HDL-cholesterol levels, and the triad of CORNEAL OPACITIES; HEMOLYTIC ANEMIA; and PROTEINURIA with renal failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Probucol is a controversial drug to inhibit ATP-binding cassette transporter A1 (ABCA1) and to exhibit some positive clinical effects such as regression of xanthomas." | 1.56 | Selective Correction of Genotype Yield by Probucol in HDL-Deficient Mice Propagation. ( Akita, N; Kobayashi, F; Tsujita, M; Yokota, T; Yokoyama, S, 2020) |
| "Therefore, LCAT deficiency impairs the former pathway, and the latter can be inhibited by probucol, which interferes with the apolipoprotein-cell interaction." | 1.31 | Effect of probucol in lecithin-cholesterol acyltransferase-deficient mice: inhibition of 2 independent cellular cholesterol-releasing pathways in vivo. ( Fukutomi, T; Ito, S; Itoh, M; Okazaki, M; Tada, T; Tomimoto, S; Tsujita, M; Usui, S; Yokoyama, S, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Komatsu, T | 1 |
| Uehara, Y | 1 |
| Tsujita, M | 2 |
| Akita, N | 1 |
| Yokota, T | 1 |
| Kobayashi, F | 1 |
| Yokoyama, S | 2 |
| Tomimoto, S | 1 |
| Okazaki, M | 1 |
| Usui, S | 1 |
| Tada, T | 1 |
| Fukutomi, T | 1 |
| Ito, S | 1 |
| Itoh, M | 1 |
3 other studies available for probucol and Lecithin Cholesterol Acyltransferase Deficiency
| Article | Year |
|---|---|
What Kind of Probucol Affects Normalizing Male Birth?
Topics: Animals; ATP Binding Cassette Transporter 1; Cholesterol, HDL; Female; Fertility; Lecithin Cholester | 2020 |
Selective Correction of Genotype Yield by Probucol in HDL-Deficient Mice Propagation.
Topics: Animals; ATP Binding Cassette Transporter 1; Cholesterol, HDL; Female; Genotype; Lecithin Cholestero | 2020 |
Effect of probucol in lecithin-cholesterol acyltransferase-deficient mice: inhibition of 2 independent cellular cholesterol-releasing pathways in vivo.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Cholesterol, Dietary; Dose-Response Relationship, Dr | 2001 |