probucol has been researched along with Hypertrophy in 1 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "This probucol-induced increase in HO-1 mRNA and inhibition of RASMC proliferation was prevented by the HO inhibitor Sn(IV) protoporphyrin or transfection with small interference RNA (siRNA) to knockdown HO-1, but not by inactive Cu(II) protoporphyrin or scrambled siRNA." | 1.32 | Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1. ( Deng, YM; Stocker, R; Witting, PK; Wu, BJ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Deng, YM | 1 |
| Wu, BJ | 1 |
| Witting, PK | 1 |
| Stocker, R | 1 |
1 other study available for probucol and Hypertrophy
| Article | Year |
|---|---|
Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1.
Topics: Animals; Anticholesteremic Agents; Antioxidants; Aorta, Abdominal; Apoptosis; Arteriosclerosis; Cath | 2004 |