probucol has been researched along with Hypertension in 9 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To observe the therapeutic effect of probucol on serum malondialdehyde (MDA) and superoxide dismutase (SOD) in patients with primary hypertension." | 9.16 | [Effect of probucol on serum malondialdehyde and superoxide dismutase in patients with primary hypertension]. ( Rong, H; Tan, M, 2012) |
| "A total of 120 patients with hypertension were randomly divided to three groups (n = 40 each): group 1 (standard medication), group 2 (adding folic acid 5 mg/day and vitamin B(12) 500 µg twice daily) and group 3 (adding folic acid 5 mg/day and vitamin B(12) 500 µg twice daily and probucol 500 mg twice daily)." | 9.16 | [Impact of adding folic acid, vitamin B(12) and probucol to standard antihypertensive medication on plasma homocysteine and asymmetric dimethylarginine levels of essential hypertension patients]. ( Li, X; Ma, JP; Wang, CX; Wang, L; Wu, CJ; Xia, XS, 2012) |
| "We examined the effect of probucol, a lipid-lowering agent with strong antioxidant properties, on neurological events and survival in stroke-prone spontaneously hypertensive rats (SHRSP)." | 7.70 | Failure of probucol to prolong survival in salt-loaded stroke-prone spontaneously hypertensive rats. ( Fujimura, A; Kawaguchi, A; Kitoh, Y; Miyashita, F; Sugimoto, K; Tsutsumi, H, 2000) |
| "To observe the therapeutic effect of probucol on serum malondialdehyde (MDA) and superoxide dismutase (SOD) in patients with primary hypertension." | 5.16 | [Effect of probucol on serum malondialdehyde and superoxide dismutase in patients with primary hypertension]. ( Rong, H; Tan, M, 2012) |
| "A total of 120 patients with hypertension were randomly divided to three groups (n = 40 each): group 1 (standard medication), group 2 (adding folic acid 5 mg/day and vitamin B(12) 500 µg twice daily) and group 3 (adding folic acid 5 mg/day and vitamin B(12) 500 µg twice daily and probucol 500 mg twice daily)." | 5.16 | [Impact of adding folic acid, vitamin B(12) and probucol to standard antihypertensive medication on plasma homocysteine and asymmetric dimethylarginine levels of essential hypertension patients]. ( Li, X; Ma, JP; Wang, CX; Wang, L; Wu, CJ; Xia, XS, 2012) |
| "Uric acid has ever been considered as one of contrast induced acute kidney injury's risk factors." | 3.80 | Atorvastatin combining with probucol: a new way to reduce serum uric acid level during perioperative period of interventional procedure. ( Cong, H; Fu, N; Jin, D; Li, H; Li, X; Ma, H; Wang, Y, 2014) |
| "We examined the effect of probucol, a lipid-lowering agent with strong antioxidant properties, on neurological events and survival in stroke-prone spontaneously hypertensive rats (SHRSP)." | 3.70 | Failure of probucol to prolong survival in salt-loaded stroke-prone spontaneously hypertensive rats. ( Fujimura, A; Kawaguchi, A; Kitoh, Y; Miyashita, F; Sugimoto, K; Tsutsumi, H, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 1 |
| Li, X | 2 |
| Ma, H | 1 |
| Wang, Y | 1 |
| Fu, N | 1 |
| Jin, D | 1 |
| Cong, H | 1 |
| Rong, H | 1 |
| Tan, M | 1 |
| Wu, CJ | 1 |
| Wang, L | 1 |
| Wang, CX | 1 |
| Ma, JP | 1 |
| Xia, XS | 1 |
| Ohtani, K | 1 |
| Egashira, K | 1 |
| Asselin, C | 1 |
| Shi, Y | 1 |
| Clément, R | 1 |
| Tardif, JC | 1 |
| Des Rosiers, C | 1 |
| Sharma, RC | 1 |
| Hodis, HN | 2 |
| Mack, WJ | 2 |
| Sevanian, A | 2 |
| Kramsch, DM | 1 |
| Hashimoto, S | 1 |
| Miyashita, F | 1 |
| Kawaguchi, A | 1 |
| Sugimoto, K | 1 |
| Kitoh, Y | 1 |
| Tsutsumi, H | 1 |
| Fujimura, A | 1 |
| Miettinen, TA | 1 |
| Huttunen, JK | 1 |
| Naukkarinen, V | 1 |
| Strandberg, T | 1 |
| Vanhanen, H | 1 |
1 review available for probucol and Hypertension
| Article | Year |
|---|---|
[NO and atherosclerosis].
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Arginine; Arteriosclerosis; Endothe | 2004 |
3 trials available for probucol and Hypertension
| Article | Year |
|---|---|
[Effect of probucol on serum malondialdehyde and superoxide dismutase in patients with primary hypertension].
Topics: Adult; Antioxidants; Female; Humans; Hypertension; Male; Malondialdehyde; Middle Aged; Oxidative Str | 2012 |
[Impact of adding folic acid, vitamin B(12) and probucol to standard antihypertensive medication on plasma homocysteine and asymmetric dimethylarginine levels of essential hypertension patients].
Topics: Aged; Antihypertensive Agents; Arginine; Female; Folic Acid; Homocysteine; Humans; Hypertension; Mal | 2012 |
Long-term use of probucol in the multifactorial primary prevention of vascular disease.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Cerebrovascular Disorders; Cholesterol, HDL; C | 1986 |
5 other studies available for probucol and Hypertension
| Article | Year |
|---|---|
Atorvastatin combining with probucol: a new way to reduce serum uric acid level during perioperative period of interventional procedure.
Topics: Acute Kidney Injury; Aged; Antioxidants; Atorvastatin; Biomarkers; Contrast Media; Drug Therapy, Com | 2014 |
Higher circulating 4-hydroxynonenal-protein thioether adducts correlate with more severe diastolic dysfunction in spontaneously hypertensive rats.
Topics: Aldehydes; Animals; Antioxidants; Diastole; Electrocardiography; Heart Function Tests; Heart Rate; H | 2007 |
Probucol suppresses oxidant stress in hypertensive arteries. Immunohistochemical evidence.
Topics: Animals; Antioxidants; Arteries; Blood Pressure; Cholesterol; Hypertension; Image Processing, Comput | 1996 |
Probucol reduces oxysterol formation in hypertensive rabbits.
Topics: Animals; Anticholesteremic Agents; Aorta; Cholesterol; Hypertension; Male; Probucol; Rabbits | 2000 |
Failure of probucol to prolong survival in salt-loaded stroke-prone spontaneously hypertensive rats.
Topics: Animals; Anticholesteremic Agents; Blood Pressure; Body Weight; Hypertension; Male; Probucol; Rats; | 2000 |