probucol has been researched along with Hyperlipoproteinemia Type IV in 9 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Hyperlipoproteinemia Type IV: A hypertriglyceridemia disorder, often with autosomal dominant inheritance. It is characterized by the persistent elevations of plasma TRIGLYCERIDES, endogenously synthesized and contained predominantly in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins). In contrast, the plasma CHOLESTEROL and PHOSPHOLIPIDS usually remain within normal limits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral carnitine has been reported to have a lipid-lowering effect with concomitant elevation of high density lipoprotein cholesterol (HDL-C) levels in normo- and hyperlipidemic individuals." | 1.27 | Plasma carnitine and lipid-lowering drugs. ( Davignon, J; Nestruck, AC; Pande, SV, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miettinen, TA | 1 |
| Huttunen, JK | 1 |
| Ehnholm, C | 1 |
| Kumlin, T | 1 |
| Mattila, S | 1 |
| Naukkarinen, V | 1 |
| Atmeh, RF | 1 |
| Stewart, JM | 1 |
| Boag, DE | 1 |
| Packard, CJ | 1 |
| Lorimer, AR | 1 |
| Shepherd, J | 1 |
| Mc Caughan, D | 1 |
| Lussier-Cacan, S | 1 |
| Dubreuil-Quidoz, S | 1 |
| Roederer, G | 1 |
| Leboeuf, N | 1 |
| Boulet, L | 1 |
| de Langavant, GC | 1 |
| Davignon, J | 2 |
| Naruszewicz, M | 1 |
| Gotto, AM | 1 |
| Jones, PH | 1 |
| Scott, LW | 1 |
| Goranov, I | 1 |
| Naumova, R | 1 |
| Kerekovska, M | 1 |
| Balabanski, L | 1 |
| Schaefer, EJ | 1 |
| Levy, RI | 1 |
| Nestruck, AC | 1 |
| Pande, SV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Estudio clínico Fase III Para Evaluar la Eficacia terapéutica en Pacientes Mexicanos Con Dislipidemia Mediante el Uso vía Oral de L-Carnitina + Atorvastatina Comparado Con Atorvastatina[NCT03696940] | Phase 3 | 120 participants (Actual) | Interventional | 2018-05-28 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for probucol and Hyperlipoproteinemia Type IV
| Article | Year |
|---|---|
Recommendations for treatment of hyperlipidemia in adults. A joint statement of the Nutrition Committee and the Council on Arteriosclerosis.
Topics: Cholesterol; Clofibrate; Coronary Disease; Female; Gemfibrozil; Humans; Hypercholesterolemia; Hyperl | 1984 |
The diagnosis and management of hyperlipidemia.
Topics: Adolescent; Adult; Child; Child, Preschool; Cholesterol; Cholestyramine Resin; Chylomicrons; Clofibr | 1986 |
Pathogenesis and management of lipoprotein disorders.
Topics: Abetalipoproteinemia; Adolescent; Adult; Aged; Child; Child, Preschool; Cholestyramine Resin; Chylom | 1985 |
2 trials available for probucol and Hyperlipoproteinemia Type IV
| Article | Year |
|---|---|
Effect of long-term antihypertensive and hypolipidemic treatment on high density lipoprotein cholesterol and apolipoproteins A-I and A-II.
Topics: Antihypertensive Agents; Apolipoproteins; Body Weight; Cholesterol; Clofibrate; Humans; Hyperlipopro | 1980 |
[Comparative effects of probucol and placebo on blood cholesterol in patients on long-term treatment (author's transl)].
Topics: Cholesterol; Coronary Disease; Double-Blind Method; Humans; Hyperlipoproteinemia Type II; Hyperlipop | 1980 |
4 other studies available for probucol and Hyperlipoproteinemia Type IV
| Article | Year |
|---|---|
The hypolipidemic action of probucol: a study of its effects on high and low density lipoproteins.
Topics: Adult; Apolipoproteins; Apolipoproteins A; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; | 1983 |
Influence of probucol on enhanced LDL oxidation after fish oil treatment of hypertriglyceridemic patients.
Topics: Adult; Antioxidants; Cholesterol, HDL; Cholesterol, VLDL; Copper; Fish Oils; Humans; Hyperlipoprotei | 1993 |
[Indications for and the therapeutic action of hypolipidemic agents in patients with hyperlipoproteinemias].
Topics: Bezafibrate; Cholesterol; Drug Evaluation; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemi | 1987 |
Plasma carnitine and lipid-lowering drugs.
Topics: Carnitine; Cholesterol, HDL; Clofibrate; Female; Humans; Hyperlipidemia, Familial Combined; Hyperlip | 1985 |