probucol has been researched along with Hyperlipoproteinemia Type III in 6 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Hyperlipoproteinemia Type III: An autosomal recessively inherited disorder characterized by the accumulation of intermediate-density lipoprotein (IDL or broad-beta-lipoprotein). IDL has a CHOLESTEROL to TRIGLYCERIDES ratio greater than that of VERY-LOW-DENSITY LIPOPROTEINS. This disorder is due to mutation of APOLIPOPROTEINS E, a receptor-binding component of VLDL and CHYLOMICRONS, resulting in their reduced clearance and high plasma levels of both cholesterol and triglycerides.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with probucol resulted in the improvement of both hyperlipoproteinemia and proteinuria with the disappearance of the lipoprotein thrombi in the glomerular capillary without any change in the mesangial IgA deposition." | 2.39 | A case of lipoprotein glomerulopathy successfully treated with probucol. ( Amenomori, M; Haneda, M; Hidaka, H; Kikkawa, R; Maeda, S; Morikawa, J; Nishigaki, I; Shigeta, Y, 1994) |
| "Probucol is a drug with hypolipidemic effect from the group of diphenols." | 1.27 | [Clinical research on the hypolipidemic action of a probucol preparation]. ( Balabanski, L; Goranov, I; Kerekovska, M; Naumova, R, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amenomori, M | 1 |
| Haneda, M | 1 |
| Morikawa, J | 1 |
| Nishigaki, I | 1 |
| Maeda, S | 1 |
| Hidaka, H | 1 |
| Kikkawa, R | 1 |
| Shigeta, Y | 1 |
| Lussier-Cacan, S | 1 |
| Dubreuil-Quidoz, S | 1 |
| Roederer, G | 1 |
| Leboeuf, N | 1 |
| Boulet, L | 1 |
| de Langavant, GC | 1 |
| Davignon, J | 1 |
| Naruszewicz, M | 1 |
| Gotto, AM | 1 |
| Jones, PH | 1 |
| Scott, LW | 1 |
| Naumova, R | 1 |
| Kerekovska, M | 1 |
| Goranov, I | 1 |
| Balabanski, L | 1 |
| Schaefer, EJ | 1 |
| Levy, RI | 1 |
| Engst, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Estudio clínico Fase III Para Evaluar la Eficacia terapéutica en Pacientes Mexicanos Con Dislipidemia Mediante el Uso vía Oral de L-Carnitina + Atorvastatina Comparado Con Atorvastatina[NCT03696940] | Phase 3 | 120 participants (Actual) | Interventional | 2018-05-28 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for probucol and Hyperlipoproteinemia Type III
| Article | Year |
|---|---|
A case of lipoprotein glomerulopathy successfully treated with probucol.
Topics: Female; Glomerulonephritis, IGA; Humans; Hyperlipoproteinemia Type III; Kidney Diseases; Lipids; Mid | 1994 |
The diagnosis and management of hyperlipidemia.
Topics: Adolescent; Adult; Child; Child, Preschool; Cholesterol; Cholestyramine Resin; Chylomicrons; Clofibr | 1986 |
Pathogenesis and management of lipoprotein disorders.
Topics: Abetalipoproteinemia; Adolescent; Adult; Aged; Child; Child, Preschool; Cholestyramine Resin; Chylom | 1985 |
3 other studies available for probucol and Hyperlipoproteinemia Type III
| Article | Year |
|---|---|
Influence of probucol on enhanced LDL oxidation after fish oil treatment of hypertriglyceridemic patients.
Topics: Adult; Antioxidants; Cholesterol, HDL; Cholesterol, VLDL; Copper; Fish Oils; Humans; Hyperlipoprotei | 1993 |
[Clinical research on the hypolipidemic action of a probucol preparation].
Topics: Adult; Cholesterol; Drug Evaluation; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type | 1986 |
[Hyperlipoproteinemia type III with apolipoprotein E phenotype 2/2].
Topics: Apolipoproteins E; Cholesterol; Cholesterol, HDL; Chylomicrons; Humans; Hyperlipoproteinemia Type II | 1985 |