Page last updated: 2024-11-03

probucol and Huntington Disease

probucol has been researched along with Huntington Disease in 3 studies

Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.

Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Research Excerpts

ExcerptRelevanceReference
" Our data suggest that the two studied toxic models (QA and 3-NP) or the combined model (QA plus 3-NP) can generate complex patterns of damage, which involve metabolic compromise, ROS formation, and oxidative stress."1.38Probucol modulates oxidative stress and excitotoxicity in Huntington's disease models in vitro. ( Colle, D; Farina, M; Hartwig, JM; Soares, FA, 2012)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
de Paula Nascimento-Castro, C1
Wink, AC1
da FĂ´nseca, VS1
Bianco, CD1
Winkelmann-Duarte, EC1
Farina, M3
Rodrigues, ALS1
Gil-Mohapel, J1
de Bem, AF1
Brocardo, PS1
Colle, D2
Santos, DB1
Moreira, EL1
Hartwig, JM2
dos Santos, AA1
Zimmermann, LT1
Hort, MA1
Soares, FA1

Other Studies

3 other studies available for probucol and Huntington Disease

ArticleYear
Antidepressant Effects of Probucol on Early-Symptomatic YAC128 Transgenic Mice for Huntington's Disease.
    Neural plasticity, 2018, Volume: 2018

    Topics: Animals; Antidepressive Agents; Antioxidants; Cell Differentiation; Cell Proliferation; Cholesterol;

2018
Probucol increases striatal glutathione peroxidase activity and protects against 3-nitropropionic acid-induced pro-oxidative damage in rats.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Animals; Antioxidants; Catalase; Corpus Striatum; Drug Evaluation, Preclinical; Electron Transport C

2013
Probucol modulates oxidative stress and excitotoxicity in Huntington's disease models in vitro.
    Brain research bulletin, 2012, Mar-10, Volume: 87, Issue:4-5

    Topics: Animals; Antioxidants; Convulsants; Corpus Striatum; Disease Models, Animal; Huntington Disease; Lip

2012