probucol has been researched along with Electrocardiogram QT Prolonged in 11 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a patient who experienced a reversible prolongation of the QT interval and episodes of syncope while receiving probucol." | 7.69 | Probucol-induced QT prolongation and syncope. ( Ito, M; Ohtsuka, E; Oribe, K; Oribe, M; Seita, M; Tamura, M; Ueki, Y, 1994) |
| "From published articles and adverse reactions reports filed with the FDA (available through the Freedom of Information Act), we analyzed occurrences of tachyarrhythmias and the magnitude of QTc prolongation associated with probucol therapy." | 4.79 | Probucol-associated tachyarrhythmic events and QT prolongation: importance of gender. ( Baga, JJ; Frankovich, D; Fromm, BS; Kawasaki, R; Lehmann, MH; Machado, C; Pires, LA; Reinoehl, J; Steinman, RT, 1996) |
| "We report a patient who experienced a reversible prolongation of the QT interval and episodes of syncope while receiving probucol." | 3.69 | Probucol-induced QT prolongation and syncope. ( Ito, M; Ohtsuka, E; Oribe, K; Oribe, M; Seita, M; Tamura, M; Ueki, Y, 1994) |
| "The QT, QTc, QS2 intervals, pre-ejection period-left ventricular ejection time ratios and serum lipoprotein levels were measured in 8 patients with primary hypercholesterolemia before and after a 3-month therapy with probucol, 1 g/day." | 3.67 | The effects of probucol on QT/QS2 relation and systolic time intervals. ( Fenyvesi, T; László, Z; Littmann, L; Romics, L, 1988) |
| "Probucol is a cholesterol-lowering drug that could reduce hERG current by decreasing plasma membrane hERG protein expression and eventually cause long QT syndrome." | 1.42 | Mechanisms underlying probucol-induced hERG-channel deficiency. ( Geng, HZ; Li, BX; Liu, LR; Lv, L; Shi, YQ; Yan, CC; Yan, M; Zhang, X, 2015) |
| "Probucol, which is a cholesterol-lowering drug and clinically reported to cause QT prolongation, potently inhibited the IKs in a concentration-dependent manner, with a half maximal inhibitory concentration of 149." | 1.38 | Chronic probucol treatment decreases the slow component of the delayed-rectifier potassium current in CHO cells transfected with KCNQ1 and KCNE1: a novel mechanism of QT prolongation. ( Arai, T; Miyamoto, N; Sawada, K; Taniguchi, T; Uesugi, M; Yoshinaga, T, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Yamashita, S | 1 |
| Masuda, D | 1 |
| Matsuzawa, Y | 1 |
| Nogawa, H | 1 |
| Kawai, T | 1 |
| Yajima, M | 1 |
| Miura, M | 1 |
| Ogawa, T | 1 |
| Murakami, K | 1 |
| Shi, YQ | 1 |
| Yan, CC | 1 |
| Zhang, X | 1 |
| Yan, M | 1 |
| Liu, LR | 1 |
| Geng, HZ | 1 |
| Lv, L | 1 |
| Li, BX | 1 |
| Guo, J | 1 |
| Li, X | 1 |
| Shallow, H | 1 |
| Xu, J | 1 |
| Yang, T | 1 |
| Massaeli, H | 1 |
| Li, W | 1 |
| Sun, T | 1 |
| Pierce, GN | 1 |
| Zhang, S | 1 |
| Taniguchi, T | 1 |
| Uesugi, M | 1 |
| Arai, T | 1 |
| Yoshinaga, T | 1 |
| Miyamoto, N | 1 |
| Sawada, K | 1 |
| Hayashi, K | 1 |
| Shimizu, M | 1 |
| Ino, H | 1 |
| Yamaguchi, M | 1 |
| Terai, H | 1 |
| Hoshi, N | 1 |
| Higashida, H | 1 |
| Terashima, N | 1 |
| Uno, Y | 1 |
| Kanaya, H | 1 |
| Mabuchi, H | 2 |
| Tamura, M | 1 |
| Ueki, Y | 1 |
| Ohtsuka, E | 1 |
| Oribe, M | 1 |
| Seita, M | 1 |
| Oribe, K | 1 |
| Ito, M | 1 |
| Kajinami, K | 1 |
| Takekoshi, N | 1 |
| Ohya, Y | 1 |
| Kumamoto, K | 1 |
| Abe, I | 1 |
| Tsubota, Y | 1 |
| Fujishima, M | 1 |
| Reinoehl, J | 1 |
| Frankovich, D | 1 |
| Machado, C | 1 |
| Kawasaki, R | 1 |
| Baga, JJ | 1 |
| Pires, LA | 1 |
| Steinman, RT | 1 |
| Fromm, BS | 1 |
| Lehmann, MH | 1 |
| Romics, L | 1 |
| Littmann, L | 1 |
| László, Z | 1 |
| Fenyvesi, T | 1 |
1 review available for probucol and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Probucol-associated tachyarrhythmic events and QT prolongation: importance of gender.
Topics: Adult; Aged; Anticholesteremic Agents; Female; Humans; Long QT Syndrome; Male; Middle Aged; Patient | 1996 |
10 other studies available for probucol and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
New Horizons for Probucol, an Old, Mysterious Drug.
Topics: Anticholesteremic Agents; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Clinical Tria | 2021 |
Effects of probucol, a typical hERG expression inhibitor, on in vivo QT interval prolongation in conscious dogs.
Topics: Animals; Anticholesteremic Agents; Aza Compounds; Dogs; Drug Interactions; Ether-A-Go-Go Potassium C | 2013 |
Mechanisms underlying probucol-induced hERG-channel deficiency.
Topics: Anticholesteremic Agents; Carbachol; Dose-Response Relationship, Drug; Endosomal Sorting Complexes R | 2015 |
Involvement of caveolin in probucol-induced reduction in hERG plasma-membrane expression.
Topics: Anticholesteremic Agents; Caveolin 1; Cell Line; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Cha | 2011 |
Chronic probucol treatment decreases the slow component of the delayed-rectifier potassium current in CHO cells transfected with KCNQ1 and KCNE1: a novel mechanism of QT prolongation.
Topics: Animals; Anticholesteremic Agents; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Dose-Respon | 2012 |
Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG.
Topics: Animals; Anticholesteremic Agents; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potass | 2004 |
Probucol-induced QT prolongation and syncope.
Topics: Atrial Fibrillation; Diltiazem; Electrocardiography; Female; Humans; Hypercholesterolemia; Long QT S | 1994 |
Propranolol for probucol-induced QT prolongation with polymorphic ventricular tachycardia.
Topics: Electrocardiography; Female; Humans; Long QT Syndrome; Middle Aged; Probucol; Propranolol; Torsades | 1993 |
Factors related to QT interval prolongation during probucol treatment.
Topics: Electrocardiography; Female; Humans; Hypercholesterolemia; Long QT Syndrome; Male; Middle Aged; Prob | 1993 |
The effects of probucol on QT/QS2 relation and systolic time intervals.
Topics: Adult; Arrhythmias, Cardiac; Cardiac Output; Cholesterol; Electrocardiography; Female; Humans; Hyper | 1988 |