Page last updated: 2024-11-03

probucol and Edema

probucol has been researched along with Edema in 2 studies

Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
"Overt pain-like behaviors were determined by the number of abdominal writhings induced by phenyl-p-benzoquinone and acetic acid."7.85Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017)
"Overt pain-like behaviors were determined by the number of abdominal writhings induced by phenyl-p-benzoquinone and acetic acid."3.85Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017)
"Because atherosclerosis is an inflammatory process involving a series of pathological events such as dyslipidemia, oxidative stress, and blood clotting mechanisms, we hereby report the synthesis and evaluation of novel compounds in which antioxidant, anti-inflammatory, and squalene synthase (SQS) inhibitory/hypolipidemic activities are combined in simple molecules through design."1.40Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity. ( Kourounakis, AP; Matralis, AN, 2014)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Matralis, AN1
Kourounakis, AP1
Zucoloto, AZ1
Manchope, MF1
Staurengo-Ferrari, L1
Alves-Filho, JC1
Cunha, TM1
Antunes, MM1
Menezes, GB1
Cunha, FQ1
Casagrande, R1
Verri, WA1

Other Studies

2 other studies available for probucol and Edema

ArticleYear
Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity.
    Journal of medicinal chemistry, 2014, Mar-27, Volume: 57, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Atherosclerosis; Biphenyl Compounds;

2014
Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2017, Volume: 66, Issue:7

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Benzoquinones; Carrage

2017