probucol has been researched along with Diabetic Retinopathy in 5 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cataract formation occurred after 13 weeks in diabetic animals compared with 17 weeks for those treated with aminoguanidine, and 16 weeks for those treated with probucol (p < 0." | 3.70 | Effects of inhibition of glycation and oxidative stress on the development of cataract and retinal vessel abnormalities in diabetic rats. ( Agardh, C; Agardh, E; Hultberg, B, 2000) |
| "Probucol treatment prevented diabetes-induced lesions." | 1.56 | Probucol Prevents Diabetes-Induced Retinal Neuronal Degeneration through Upregulating Nrf2. ( Chen, ZP; Liu, HW; Luo, Y; Zhou, YF, 2020) |
| "Probucol is an antihyperlipidemic drug with potent antioxidant properties." | 1.46 | Probucol prevents the attenuation of β ( Higashi, K; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Wakao, S, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, HW | 1 |
| Luo, Y | 1 |
| Zhou, YF | 1 |
| Chen, ZP | 1 |
| Mori, A | 1 |
| Higashi, K | 1 |
| Wakao, S | 1 |
| Sakamoto, K | 1 |
| Ishii, K | 1 |
| Nakahara, T | 1 |
| Agardh, E | 2 |
| Hultberg, B | 1 |
| Agardh, C | 1 |
| Bruun, A | 1 |
| Agardh, CD | 1 |
| Kim, J | 1 |
| Kim, KS | 1 |
| Shinn, JW | 1 |
| Oh, YS | 1 |
| Kim, HT | 1 |
| Jo, I | 1 |
| Shinn, SH | 1 |
5 other studies available for probucol and Diabetic Retinopathy
| Article | Year |
|---|---|
Probucol Prevents Diabetes-Induced Retinal Neuronal Degeneration through Upregulating Nrf2.
Topics: Animals; Antioxidants; Diabetic Retinopathy; Mice; Mice, Inbred C57BL; Neurons; NF-E2-Related Factor | 2020 |
Probucol prevents the attenuation of β
Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Animals; Anticholesteremic Agents; Arterioles; Blood | 2017 |
Effects of inhibition of glycation and oxidative stress on the development of cataract and retinal vessel abnormalities in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Cataract; Cysteine; Diabetes Mellitus, Experimental; Diabetic R | 2000 |
Retinal glial cell immunoreactivity and neuronal cell changes in rats with STZ-induced diabetes.
Topics: Animals; Antioxidants; Calbindins; Carrier Proteins; Cell Count; cis-trans-Isomerases; Diabetes Mell | 2001 |
The effect of antioxidants on glycated albumin-induced cytotoxicity in bovine retinal pericytes.
Topics: Animals; Antioxidants; Ascorbic Acid; Cattle; Cell Death; Cell Survival; Cells, Cultured; Chromans; | 2002 |