Page last updated: 2024-11-03

probucol and Cirrhosis

probucol has been researched along with Cirrhosis in 6 studies

Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.

Research Excerpts

ExcerptRelevanceReference
"Probucol treatment improves erectile function by restoring endothelial function and preventing cavernous fibrosis in streptozotocin-induced diabetic rats."7.83Probucol Improves Erectile Function by Restoring Endothelial Function and Preventing Cavernous Fibrosis in Streptozotocin-induced Diabetic Rats. ( Chen, D; Fu, Q; Li, B; Sun, DQ; Zhang, H; Zhang, KQ, 2016)
" However, the underlying mechanisms for the increased propensity for AF in the setting of DM and the potential effects of probucol on atrial remodeling remain unclear."7.81Probucol prevents atrial remodeling by inhibiting oxidative stress and TNF-α/NF-κB/TGF-β signal transduction pathway in alloxan-induced diabetic rabbits. ( Cheng, L; Fu, H; Li, G; Li, J; Liu, C; Liu, T; Wang, X, 2015)
"The lipid-lowering agent probucol may be efficacious, through its antioxidant properties, to limit and reverse the vascular endothelial dysfunction associated with left ventricular hypertrophy (LVH)."7.73Role of probucol on endothelial dysfunction of epicardial coronary arteries associated with left ventricular hypertrophy. ( Aubin, MC; Carrier, M; Perrault, LP; Shi, YF; Tardif, JC, 2006)
"Probucol treatment improves erectile function by restoring endothelial function and preventing cavernous fibrosis in streptozotocin-induced diabetic rats."3.83Probucol Improves Erectile Function by Restoring Endothelial Function and Preventing Cavernous Fibrosis in Streptozotocin-induced Diabetic Rats. ( Chen, D; Fu, Q; Li, B; Sun, DQ; Zhang, H; Zhang, KQ, 2016)
" However, the underlying mechanisms for the increased propensity for AF in the setting of DM and the potential effects of probucol on atrial remodeling remain unclear."3.81Probucol prevents atrial remodeling by inhibiting oxidative stress and TNF-α/NF-κB/TGF-β signal transduction pathway in alloxan-induced diabetic rabbits. ( Cheng, L; Fu, H; Li, G; Li, J; Liu, C; Liu, T; Wang, X, 2015)
"The lipid-lowering agent probucol may be efficacious, through its antioxidant properties, to limit and reverse the vascular endothelial dysfunction associated with left ventricular hypertrophy (LVH)."3.73Role of probucol on endothelial dysfunction of epicardial coronary arteries associated with left ventricular hypertrophy. ( Aubin, MC; Carrier, M; Perrault, LP; Shi, YF; Tardif, JC, 2006)
"Probucol is a bisphenolic compound that lowers serum cholesterol and also has potent antioxidant properties."1.28Effects of probucol in renal function and structure in rats with subtotal kidney ablation. ( Klahr, S; Modi, KS; Purkerson, ML; Schreiner, GF, 1992)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, Z1
Shi, S1
Zhu, H1
Chen, Y1
Zhang, Y1
Zheng, Z1
Wang, X2
Fu, H1
Li, G1
Liu, C1
Li, J1
Cheng, L1
Liu, T1
Zhang, KQ1
Chen, D1
Sun, DQ1
Zhang, H1
Li, B1
Fu, Q1
Aubin, MC1
Carrier, M1
Shi, YF1
Tardif, JC1
Perrault, LP1
Drukker, A1
Eddy, AA1
Modi, KS1
Schreiner, GF1
Purkerson, ML1
Klahr, S1

Other Studies

6 other studies available for probucol and Cirrhosis

ArticleYear
Novel ASK1 Inhibitor AGI-1067 Attenuates AGE-Induced Fibrotic Response by Suppressing the MKKs/p38 MAPK Pathway in Human Coronary Arterial Smooth Muscle Cells.
    International heart journal, 2018, Nov-28, Volume: 59, Issue:6

    Topics: Blotting, Western; Cardiovascular Agents; Cells, Cultured; Coronary Vessels; Fibrosis; Glycation End

2018
Probucol prevents atrial remodeling by inhibiting oxidative stress and TNF-α/NF-κB/TGF-β signal transduction pathway in alloxan-induced diabetic rabbits.
    Journal of cardiovascular electrophysiology, 2015, Volume: 26, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Atrial Fibrillation; Atrial Remodeling; Biomarkers;

2015
Probucol Improves Erectile Function by Restoring Endothelial Function and Preventing Cavernous Fibrosis in Streptozotocin-induced Diabetic Rats.
    Urology, 2016, Volume: 91

    Topics: Animals; Anticholesteremic Agents; Diabetes Mellitus, Experimental; Endothelium; Erectile Dysfunctio

2016
Role of probucol on endothelial dysfunction of epicardial coronary arteries associated with left ventricular hypertrophy.
    Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:5

    Topics: Angiotensin II; Animals; Antioxidants; Bradykinin; Coronary Vessels; Cyclic GMP; Endothelium, Vascul

2006
Failure of antioxidant therapy to attenuate interstitial disease in rats with reversible nephrotic syndrome.
    Journal of the American Society of Nephrology : JASN, 1998, Volume: 9, Issue:2

    Topics: Animals; Anticholesteremic Agents; Antioxidants; Cholesterol; Collagen; Female; Fibronectins; Fibros

1998
Effects of probucol in renal function and structure in rats with subtotal kidney ablation.
    The Journal of laboratory and clinical medicine, 1992, Volume: 120, Issue:2

    Topics: Animals; Atrophy; Blood Pressure; Body Weight; Cholesterol; Female; Fibrosis; Hematocrit; Kidney; Ki

1992