probucol has been researched along with Cirrhosis in 6 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Probucol treatment improves erectile function by restoring endothelial function and preventing cavernous fibrosis in streptozotocin-induced diabetic rats." | 7.83 | Probucol Improves Erectile Function by Restoring Endothelial Function and Preventing Cavernous Fibrosis in Streptozotocin-induced Diabetic Rats. ( Chen, D; Fu, Q; Li, B; Sun, DQ; Zhang, H; Zhang, KQ, 2016) |
| " However, the underlying mechanisms for the increased propensity for AF in the setting of DM and the potential effects of probucol on atrial remodeling remain unclear." | 7.81 | Probucol prevents atrial remodeling by inhibiting oxidative stress and TNF-α/NF-κB/TGF-β signal transduction pathway in alloxan-induced diabetic rabbits. ( Cheng, L; Fu, H; Li, G; Li, J; Liu, C; Liu, T; Wang, X, 2015) |
| "The lipid-lowering agent probucol may be efficacious, through its antioxidant properties, to limit and reverse the vascular endothelial dysfunction associated with left ventricular hypertrophy (LVH)." | 7.73 | Role of probucol on endothelial dysfunction of epicardial coronary arteries associated with left ventricular hypertrophy. ( Aubin, MC; Carrier, M; Perrault, LP; Shi, YF; Tardif, JC, 2006) |
| "Probucol treatment improves erectile function by restoring endothelial function and preventing cavernous fibrosis in streptozotocin-induced diabetic rats." | 3.83 | Probucol Improves Erectile Function by Restoring Endothelial Function and Preventing Cavernous Fibrosis in Streptozotocin-induced Diabetic Rats. ( Chen, D; Fu, Q; Li, B; Sun, DQ; Zhang, H; Zhang, KQ, 2016) |
| " However, the underlying mechanisms for the increased propensity for AF in the setting of DM and the potential effects of probucol on atrial remodeling remain unclear." | 3.81 | Probucol prevents atrial remodeling by inhibiting oxidative stress and TNF-α/NF-κB/TGF-β signal transduction pathway in alloxan-induced diabetic rabbits. ( Cheng, L; Fu, H; Li, G; Li, J; Liu, C; Liu, T; Wang, X, 2015) |
| "The lipid-lowering agent probucol may be efficacious, through its antioxidant properties, to limit and reverse the vascular endothelial dysfunction associated with left ventricular hypertrophy (LVH)." | 3.73 | Role of probucol on endothelial dysfunction of epicardial coronary arteries associated with left ventricular hypertrophy. ( Aubin, MC; Carrier, M; Perrault, LP; Shi, YF; Tardif, JC, 2006) |
| "Probucol is a bisphenolic compound that lowers serum cholesterol and also has potent antioxidant properties." | 1.28 | Effects of probucol in renal function and structure in rats with subtotal kidney ablation. ( Klahr, S; Modi, KS; Purkerson, ML; Schreiner, GF, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, S | 1 |
| Zhu, H | 1 |
| Chen, Y | 1 |
| Zhang, Y | 1 |
| Zheng, Z | 1 |
| Wang, X | 2 |
| Fu, H | 1 |
| Li, G | 1 |
| Liu, C | 1 |
| Li, J | 1 |
| Cheng, L | 1 |
| Liu, T | 1 |
| Zhang, KQ | 1 |
| Chen, D | 1 |
| Sun, DQ | 1 |
| Zhang, H | 1 |
| Li, B | 1 |
| Fu, Q | 1 |
| Aubin, MC | 1 |
| Carrier, M | 1 |
| Shi, YF | 1 |
| Tardif, JC | 1 |
| Perrault, LP | 1 |
| Drukker, A | 1 |
| Eddy, AA | 1 |
| Modi, KS | 1 |
| Schreiner, GF | 1 |
| Purkerson, ML | 1 |
| Klahr, S | 1 |
6 other studies available for probucol and Cirrhosis
| Article | Year |
|---|---|
Novel ASK1 Inhibitor AGI-1067 Attenuates AGE-Induced Fibrotic Response by Suppressing the MKKs/p38 MAPK Pathway in Human Coronary Arterial Smooth Muscle Cells.
Topics: Blotting, Western; Cardiovascular Agents; Cells, Cultured; Coronary Vessels; Fibrosis; Glycation End | 2018 |
Probucol prevents atrial remodeling by inhibiting oxidative stress and TNF-α/NF-κB/TGF-β signal transduction pathway in alloxan-induced diabetic rabbits.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Atrial Fibrillation; Atrial Remodeling; Biomarkers; | 2015 |
Probucol Improves Erectile Function by Restoring Endothelial Function and Preventing Cavernous Fibrosis in Streptozotocin-induced Diabetic Rats.
Topics: Animals; Anticholesteremic Agents; Diabetes Mellitus, Experimental; Endothelium; Erectile Dysfunctio | 2016 |
Role of probucol on endothelial dysfunction of epicardial coronary arteries associated with left ventricular hypertrophy.
Topics: Angiotensin II; Animals; Antioxidants; Bradykinin; Coronary Vessels; Cyclic GMP; Endothelium, Vascul | 2006 |
Failure of antioxidant therapy to attenuate interstitial disease in rats with reversible nephrotic syndrome.
Topics: Animals; Anticholesteremic Agents; Antioxidants; Cholesterol; Collagen; Female; Fibronectins; Fibros | 1998 |
Effects of probucol in renal function and structure in rats with subtotal kidney ablation.
Topics: Animals; Atrophy; Blood Pressure; Body Weight; Cholesterol; Female; Fibrosis; Hematocrit; Kidney; Ki | 1992 |