probucol has been researched along with Carotid Artery Diseases in 9 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Carotid Artery Diseases: Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To observe the effects of combination of Lumbrukinase Capsule (LC) and Probucol Tablet (PT) in treating cerebral infarction (CI) patients' unstable atheromatous plaque of the carotid artery." | 9.15 | [Efficacy observation of combination of Lumbrukinase Capsule and Probucol Tablet in treating cerebral infarction patients' unstable atheromatous plaque of the carotid artery]. ( Chen, GH; Pan, XF; Shao, W, 2011) |
| "Carotid atherosclerosis is a strong, independent predictor of morbidity and mortality in patients with coronary heart disease (CHD)." | 6.70 | Effects of probucol and pravastatin on common carotid atherosclerosis in patients with asymptomatic hypercholesterolemia. Fukuoka Atherosclerosis Trial (FAST). ( Hayashi, J; Kashiwagi, S; Kinukawa, N; Koyanagi, S; Maeda, N; Sawayama, Y; Shimizu, C; Tatsukawa, M, 2002) |
| " The PreventIon of CArdiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage-Intima-Media Thickness (PICASSO-IMT) sub-study is designed to investigate the effects of cilostazol, probucol, or both on IMT in patients with stroke." | 5.24 | Design and Rationale of the Intima-Medial Thickness Sub-Study of the PreventIon of CArdiovascular Events in iSchemic Stroke Patients with High Risk of Cerebral hemOrrhage (PICASSO-IMT) Study. ( Kim, YJ; Kwon, SU; Lee, J; Seo, WK, 2017) |
| "To observe the effects of combination of Lumbrukinase Capsule (LC) and Probucol Tablet (PT) in treating cerebral infarction (CI) patients' unstable atheromatous plaque of the carotid artery." | 5.15 | [Efficacy observation of combination of Lumbrukinase Capsule and Probucol Tablet in treating cerebral infarction patients' unstable atheromatous plaque of the carotid artery]. ( Chen, GH; Pan, XF; Shao, W, 2011) |
| "Probucol treatment has been evaluated in 140 patients with hypercholesterolemia attending a single Lipid Clinic, in an attempt to identify the relations between lipid/lipoprotein responses and patient characteristics." | 3.69 | Clinical evaluation of probucol in hypercholesteremia: individual lipoprotein responses and inhibitory effect on carotid atherosclerosis progression. ( Baldassarre, D; Brusoni, B; Franceschini, G; Peruzzotti, G; Sirtori, CR, 1997) |
| "pneumoniae IgA and/or IgG." | 2.73 | Effect on carotid atherosclerosis of probucol plus levofloxacin for Chlamydia pneumoniae infection. ( Furusyo, N; Hayashi, J; Kikuchi, K; Maeda, S; Ohnishi, H; Sawayama, Y; Tatsukawa, M, 2007) |
| "Carotid atherosclerosis is a strong, independent predictor of morbidity and mortality in patients with coronary heart disease (CHD)." | 2.70 | Effects of probucol and pravastatin on common carotid atherosclerosis in patients with asymptomatic hypercholesterolemia. Fukuoka Atherosclerosis Trial (FAST). ( Hayashi, J; Kashiwagi, S; Kinukawa, N; Koyanagi, S; Maeda, N; Sawayama, Y; Shimizu, C; Tatsukawa, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seo, WK | 1 |
| Kim, YJ | 1 |
| Lee, J | 1 |
| Kwon, SU | 1 |
| Pan, XF | 1 |
| Shao, W | 1 |
| Chen, GH | 1 |
| Sawayama, Y | 5 |
| Tatsukawa, M | 3 |
| Okada, K | 3 |
| Maeda, N | 2 |
| Shimizu, C | 2 |
| Kikuchi, K | 2 |
| Hayashi, J | 5 |
| Maeda, S | 3 |
| Ohnishi, H | 3 |
| Furusyo, N | 2 |
| Baldassarre, D | 1 |
| Franceschini, G | 1 |
| Peruzzotti, G | 1 |
| Brusoni, B | 1 |
| Sirtori, CR | 1 |
| Pfuetze, KD | 1 |
| Dujovne, CA | 1 |
| Kinukawa, N | 1 |
| Koyanagi, S | 1 |
| Kashiwagi, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigate Effect on Mean IMT of Probucol And/or CilosTazol in Patients With Coronary Heart dIsease Taking HMGCoA Reductase Inhibitor Therapy: A Randomized, Multicenter, Multinational Study[NCT01291641] | Phase 4 | 342 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for probucol and Carotid Artery Diseases
| Article | Year |
|---|---|
Probucol.
Topics: Animals; Anticholesteremic Agents; Antioxidants; Apolipoproteins E; Arteriosclerosis; Cardiovascular | 2000 |
7 trials available for probucol and Carotid Artery Diseases
| Article | Year |
|---|---|
Design and Rationale of the Intima-Medial Thickness Sub-Study of the PreventIon of CArdiovascular Events in iSchemic Stroke Patients with High Risk of Cerebral hemOrrhage (PICASSO-IMT) Study.
Topics: Brain Ischemia; Cardiovascular Agents; Carotid Artery Diseases; Carotid Artery, Common; Carotid Inti | 2017 |
[Efficacy observation of combination of Lumbrukinase Capsule and Probucol Tablet in treating cerebral infarction patients' unstable atheromatous plaque of the carotid artery].
Topics: Adult; Aged; Animals; Biological Products; Carotid Artery Diseases; Cerebral Infarction; Female; Hum | 2011 |
Association of Chlamydia pneumoniae antibody with the cholesterol-lowering effect of statins.
Topics: Adult; Aged; Aged, 80 and over; Angiography; Antibodies, Bacterial; Blotting, Western; Carotid Arter | 2003 |
Effect of probucol on elderly hypercholesterolemic patients in the FAST study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anticholesteremic Agents; Atherosclerosis; Cardiovascul | 2006 |
Both hepatitis C virus and Chlamydia pneumoniae infection are related to the progression of carotid atherosclerosis in patients undergoing lipid lowering therapy.
Topics: Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Carotid Artery Diseases; Chlamydophila Inf | 2006 |
Effect on carotid atherosclerosis of probucol plus levofloxacin for Chlamydia pneumoniae infection.
Topics: Aged; Anti-Bacterial Agents; Anticholesteremic Agents; Carotid Arteries; Carotid Artery Diseases; Ch | 2007 |
Effects of probucol and pravastatin on common carotid atherosclerosis in patients with asymptomatic hypercholesterolemia. Fukuoka Atherosclerosis Trial (FAST).
Topics: Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Carotid Artery Diseases; Carotid Artery, C | 2002 |
1 other study available for probucol and Carotid Artery Diseases
| Article | Year |
|---|---|
Clinical evaluation of probucol in hypercholesteremia: individual lipoprotein responses and inhibitory effect on carotid atherosclerosis progression.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Anticholesteremic Agents; Arteriosclerosis; Ca | 1997 |