probucol has been researched along with Blood Pressure, High in 9 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To observe the therapeutic effect of probucol on serum malondialdehyde (MDA) and superoxide dismutase (SOD) in patients with primary hypertension." | 9.16 | [Effect of probucol on serum malondialdehyde and superoxide dismutase in patients with primary hypertension]. ( Rong, H; Tan, M, 2012) |
| "A total of 120 patients with hypertension were randomly divided to three groups (n = 40 each): group 1 (standard medication), group 2 (adding folic acid 5 mg/day and vitamin B(12) 500 µg twice daily) and group 3 (adding folic acid 5 mg/day and vitamin B(12) 500 µg twice daily and probucol 500 mg twice daily)." | 9.16 | [Impact of adding folic acid, vitamin B(12) and probucol to standard antihypertensive medication on plasma homocysteine and asymmetric dimethylarginine levels of essential hypertension patients]. ( Li, X; Ma, JP; Wang, CX; Wang, L; Wu, CJ; Xia, XS, 2012) |
| "We examined the effect of probucol, a lipid-lowering agent with strong antioxidant properties, on neurological events and survival in stroke-prone spontaneously hypertensive rats (SHRSP)." | 7.70 | Failure of probucol to prolong survival in salt-loaded stroke-prone spontaneously hypertensive rats. ( Fujimura, A; Kawaguchi, A; Kitoh, Y; Miyashita, F; Sugimoto, K; Tsutsumi, H, 2000) |
| "To observe the therapeutic effect of probucol on serum malondialdehyde (MDA) and superoxide dismutase (SOD) in patients with primary hypertension." | 5.16 | [Effect of probucol on serum malondialdehyde and superoxide dismutase in patients with primary hypertension]. ( Rong, H; Tan, M, 2012) |
| "A total of 120 patients with hypertension were randomly divided to three groups (n = 40 each): group 1 (standard medication), group 2 (adding folic acid 5 mg/day and vitamin B(12) 500 µg twice daily) and group 3 (adding folic acid 5 mg/day and vitamin B(12) 500 µg twice daily and probucol 500 mg twice daily)." | 5.16 | [Impact of adding folic acid, vitamin B(12) and probucol to standard antihypertensive medication on plasma homocysteine and asymmetric dimethylarginine levels of essential hypertension patients]. ( Li, X; Ma, JP; Wang, CX; Wang, L; Wu, CJ; Xia, XS, 2012) |
| "Uric acid has ever been considered as one of contrast induced acute kidney injury's risk factors." | 3.80 | Atorvastatin combining with probucol: a new way to reduce serum uric acid level during perioperative period of interventional procedure. ( Cong, H; Fu, N; Jin, D; Li, H; Li, X; Ma, H; Wang, Y, 2014) |
| "We examined the effect of probucol, a lipid-lowering agent with strong antioxidant properties, on neurological events and survival in stroke-prone spontaneously hypertensive rats (SHRSP)." | 3.70 | Failure of probucol to prolong survival in salt-loaded stroke-prone spontaneously hypertensive rats. ( Fujimura, A; Kawaguchi, A; Kitoh, Y; Miyashita, F; Sugimoto, K; Tsutsumi, H, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 1 |
| Li, X | 2 |
| Ma, H | 1 |
| Wang, Y | 1 |
| Fu, N | 1 |
| Jin, D | 1 |
| Cong, H | 1 |
| Rong, H | 1 |
| Tan, M | 1 |
| Wu, CJ | 1 |
| Wang, L | 1 |
| Wang, CX | 1 |
| Ma, JP | 1 |
| Xia, XS | 1 |
| Ohtani, K | 1 |
| Egashira, K | 1 |
| Asselin, C | 1 |
| Shi, Y | 1 |
| Clément, R | 1 |
| Tardif, JC | 1 |
| Des Rosiers, C | 1 |
| Sharma, RC | 1 |
| Hodis, HN | 2 |
| Mack, WJ | 2 |
| Sevanian, A | 2 |
| Kramsch, DM | 1 |
| Hashimoto, S | 1 |
| Miyashita, F | 1 |
| Kawaguchi, A | 1 |
| Sugimoto, K | 1 |
| Kitoh, Y | 1 |
| Tsutsumi, H | 1 |
| Fujimura, A | 1 |
| Miettinen, TA | 1 |
| Huttunen, JK | 1 |
| Naukkarinen, V | 1 |
| Strandberg, T | 1 |
| Vanhanen, H | 1 |
1 review available for probucol and Blood Pressure, High
| Article | Year |
|---|---|
[NO and atherosclerosis].
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Arginine; Arteriosclerosis; Endothe | 2004 |
3 trials available for probucol and Blood Pressure, High
| Article | Year |
|---|---|
[Effect of probucol on serum malondialdehyde and superoxide dismutase in patients with primary hypertension].
Topics: Adult; Antioxidants; Female; Humans; Hypertension; Male; Malondialdehyde; Middle Aged; Oxidative Str | 2012 |
[Impact of adding folic acid, vitamin B(12) and probucol to standard antihypertensive medication on plasma homocysteine and asymmetric dimethylarginine levels of essential hypertension patients].
Topics: Aged; Antihypertensive Agents; Arginine; Female; Folic Acid; Homocysteine; Humans; Hypertension; Mal | 2012 |
Long-term use of probucol in the multifactorial primary prevention of vascular disease.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Cerebrovascular Disorders; Cholesterol, HDL; C | 1986 |
5 other studies available for probucol and Blood Pressure, High
| Article | Year |
|---|---|
Atorvastatin combining with probucol: a new way to reduce serum uric acid level during perioperative period of interventional procedure.
Topics: Acute Kidney Injury; Aged; Antioxidants; Atorvastatin; Biomarkers; Contrast Media; Drug Therapy, Com | 2014 |
Higher circulating 4-hydroxynonenal-protein thioether adducts correlate with more severe diastolic dysfunction in spontaneously hypertensive rats.
Topics: Aldehydes; Animals; Antioxidants; Diastole; Electrocardiography; Heart Function Tests; Heart Rate; H | 2007 |
Probucol suppresses oxidant stress in hypertensive arteries. Immunohistochemical evidence.
Topics: Animals; Antioxidants; Arteries; Blood Pressure; Cholesterol; Hypertension; Image Processing, Comput | 1996 |
Probucol reduces oxysterol formation in hypertensive rabbits.
Topics: Animals; Anticholesteremic Agents; Aorta; Cholesterol; Hypertension; Male; Probucol; Rabbits | 2000 |
Failure of probucol to prolong survival in salt-loaded stroke-prone spontaneously hypertensive rats.
Topics: Animals; Anticholesteremic Agents; Blood Pressure; Body Weight; Hypertension; Male; Probucol; Rats; | 2000 |