probucol has been researched along with Atrial Remodeling in 5 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Atrial Remodeling: Long-term changes in the electrophysiological parameters and/or anatomical structures of the HEART ATRIA that result from prolonged changes in atrial rate, often associated with ATRIAL FIBRILLATION or long periods of intense EXERCISE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, the underlying mechanisms for the increased propensity for AF in the setting of DM and the potential effects of probucol on atrial remodeling remain unclear." | 7.81 | Probucol prevents atrial remodeling by inhibiting oxidative stress and TNF-α/NF-κB/TGF-β signal transduction pathway in alloxan-induced diabetic rabbits. ( Cheng, L; Fu, H; Li, G; Li, J; Liu, C; Liu, T; Wang, X, 2015) |
| " However, the underlying mechanisms for the increased propensity for AF in the setting of DM and the potential effects of probucol on atrial remodeling remain unclear." | 3.81 | Probucol prevents atrial remodeling by inhibiting oxidative stress and TNF-α/NF-κB/TGF-β signal transduction pathway in alloxan-induced diabetic rabbits. ( Cheng, L; Fu, H; Li, G; Li, J; Liu, C; Liu, T; Wang, X, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Q | 1 |
| Liu, T | 4 |
| Ng, CY | 1 |
| Li, G | 4 |
| Fu, H | 3 |
| Liu, C | 2 |
| Li, J | 2 |
| Wang, X | 1 |
| Cheng, L | 2 |
| Ziolo, MT | 1 |
| Mohler, PJ | 1 |
| Shao, Q | 1 |
| Korantzopoulos, P | 1 |
| Ye, L | 1 |
| Liu, E | 1 |
| Xu, G | 1 |
| Yang, W | 1 |
| Tse, G | 1 |
| Zhao, J | 1 |
1 review available for probucol and Atrial Remodeling
| Article | Year |
|---|---|
Diabetes mellitus and atrial remodeling: mechanisms and potential upstream therapies.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Atrial Fibrillation; Atr | 2014 |
1 trial available for probucol and Atrial Remodeling
| Article | Year |
|---|---|
Effects of probucol on left atrial remodeling in patients with paroxysmal atrial fibrillation.
Topics: Aged; Anticholesteremic Agents; Atrial Fibrillation; Atrial Remodeling; Female; Follow-Up Studies; H | 2016 |
3 other studies available for probucol and Atrial Remodeling
| Article | Year |
|---|---|
Probucol prevents atrial remodeling by inhibiting oxidative stress and TNF-α/NF-κB/TGF-β signal transduction pathway in alloxan-induced diabetic rabbits.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Atrial Fibrillation; Atrial Remodeling; Biomarkers; | 2015 |
Defining the role of oxidative stress in atrial fibrillation and diabetes.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Atrial Fibrillation; Atrial Remodeling; Diabetes Me | 2015 |
Probucol prevents atrial ion channel remodeling in an alloxan-induced diabetes rabbit model.
Topics: Action Potentials; Alloxan; Animals; Anti-Arrhythmia Agents; Antioxidants; Atrial Fibrillation; Atri | 2016 |