probucol has been researched along with Arrhythmias, Cardiac in 7 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Probucol may have a protective effect on myocardium with respect to ischemia-reperfusion arrhythmia in the isolated rat heart, presumably due to an antioxidative effect." | 7.68 | Protective effect of probucol on ischemia-reperfusion arrhythmias in the rat heart. ( Mochizuki, S; Nagano, M; Seki, S; Tada, N; Takayama, T; Taniguchi, M; Yabe, H, 1992) |
| "Probucol is known to prolong QT intervals in some patients and to produce fatal arrhythmias in selected animal species." | 5.05 | Electrocardiographic effects of probucol. A controlled prospective clinical trial. ( Atkins, F; Chernoff, SB; DeCoursey, S; Dujovne, CA; Krehbiel, P; Wong, B, 1984) |
| "Probucol may have a protective effect on myocardium with respect to ischemia-reperfusion arrhythmia in the isolated rat heart, presumably due to an antioxidative effect." | 3.68 | Protective effect of probucol on ischemia-reperfusion arrhythmias in the rat heart. ( Mochizuki, S; Nagano, M; Seki, S; Tada, N; Takayama, T; Taniguchi, M; Yabe, H, 1992) |
| "The QT, QTc, QS2 intervals, pre-ejection period-left ventricular ejection time ratios and serum lipoprotein levels were measured in 8 patients with primary hypercholesterolemia before and after a 3-month therapy with probucol, 1 g/day." | 3.67 | The effects of probucol on QT/QS2 relation and systolic time intervals. ( Fenyvesi, T; László, Z; Littmann, L; Romics, L, 1988) |
| "In probucol treated patients QT interval prolongation was directly related to increasing probucol plasma levels (p less than 0." | 2.65 | Prolongation of the QT interval induced by probucol: demonstration of a method for determining QT interval change induced by a drug. ( Browne, KF; Cerimele, BJ; Fineberg, N; Heger, JJ; Prystowsky, EN; Zipes, DP, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McCaughan, D | 2 |
| Dujovne, CA | 1 |
| Atkins, F | 1 |
| Wong, B | 1 |
| DeCoursey, S | 1 |
| Krehbiel, P | 1 |
| Chernoff, SB | 1 |
| Browne, KF | 1 |
| Prystowsky, EN | 1 |
| Heger, JJ | 1 |
| Cerimele, BJ | 1 |
| Fineberg, N | 1 |
| Zipes, DP | 1 |
| Tada, N | 1 |
| Mochizuki, S | 1 |
| Takayama, T | 1 |
| Yabe, H | 1 |
| Seki, S | 1 |
| Taniguchi, M | 1 |
| Nagano, M | 1 |
| Romics, L | 1 |
| Littmann, L | 1 |
| László, Z | 1 |
| Fenyvesi, T | 1 |
| Cavallini, B | 1 |
| Spinolo, L | 1 |
| Guadagni, C | 1 |
| Spitali, G | 1 |
3 trials available for probucol and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Electrocardiographic effects of probucol. A controlled prospective clinical trial.
Topics: Adult; Arrhythmias, Cardiac; Cholesterol, LDL; Clinical Trials as Topic; Electrocardiography; Humans | 1984 |
Prolongation of the QT interval induced by probucol: demonstration of a method for determining QT interval change induced by a drug.
Topics: Adult; Arrhythmias, Cardiac; Cholesterol; Double-Blind Method; Electrocardiography; Female; Heart Ra | 1984 |
Nine years of treatment with probucol.
Topics: Arrhythmias, Cardiac; Cholesterol; Clinical Trials as Topic; Double-Blind Method; Electrocardiograph | 1982 |
4 other studies available for probucol and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Probucol and the QT interval.
Topics: Arrhythmias, Cardiac; Electrocardiography; Heart; Humans; Phenols; Probucol | 1982 |
Protective effect of probucol on ischemia-reperfusion arrhythmias in the rat heart.
Topics: Animals; Arrhythmias, Cardiac; Blood Flow Velocity; Cholesterol, HDL; Drug Evaluation, Preclinical; | 1992 |
The effects of probucol on QT/QS2 relation and systolic time intervals.
Topics: Adult; Arrhythmias, Cardiac; Cardiac Output; Cholesterol; Electrocardiography; Female; Humans; Hyper | 1988 |
[Probucol and malignant ventricular arrhythmias. Presentation of a case].
Topics: Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Middle Aged; Phenols; Probucol; Syncope | 1987 |