probucol has been researched along with Arrhythmia in 7 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Probucol may have a protective effect on myocardium with respect to ischemia-reperfusion arrhythmia in the isolated rat heart, presumably due to an antioxidative effect." | 7.68 | Protective effect of probucol on ischemia-reperfusion arrhythmias in the rat heart. ( Mochizuki, S; Nagano, M; Seki, S; Tada, N; Takayama, T; Taniguchi, M; Yabe, H, 1992) |
| "Probucol is known to prolong QT intervals in some patients and to produce fatal arrhythmias in selected animal species." | 5.05 | Electrocardiographic effects of probucol. A controlled prospective clinical trial. ( Atkins, F; Chernoff, SB; DeCoursey, S; Dujovne, CA; Krehbiel, P; Wong, B, 1984) |
| "Probucol may have a protective effect on myocardium with respect to ischemia-reperfusion arrhythmia in the isolated rat heart, presumably due to an antioxidative effect." | 3.68 | Protective effect of probucol on ischemia-reperfusion arrhythmias in the rat heart. ( Mochizuki, S; Nagano, M; Seki, S; Tada, N; Takayama, T; Taniguchi, M; Yabe, H, 1992) |
| "The QT, QTc, QS2 intervals, pre-ejection period-left ventricular ejection time ratios and serum lipoprotein levels were measured in 8 patients with primary hypercholesterolemia before and after a 3-month therapy with probucol, 1 g/day." | 3.67 | The effects of probucol on QT/QS2 relation and systolic time intervals. ( Fenyvesi, T; László, Z; Littmann, L; Romics, L, 1988) |
| "In probucol treated patients QT interval prolongation was directly related to increasing probucol plasma levels (p less than 0." | 2.65 | Prolongation of the QT interval induced by probucol: demonstration of a method for determining QT interval change induced by a drug. ( Browne, KF; Cerimele, BJ; Fineberg, N; Heger, JJ; Prystowsky, EN; Zipes, DP, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McCaughan, D | 2 |
| Dujovne, CA | 1 |
| Atkins, F | 1 |
| Wong, B | 1 |
| DeCoursey, S | 1 |
| Krehbiel, P | 1 |
| Chernoff, SB | 1 |
| Browne, KF | 1 |
| Prystowsky, EN | 1 |
| Heger, JJ | 1 |
| Cerimele, BJ | 1 |
| Fineberg, N | 1 |
| Zipes, DP | 1 |
| Tada, N | 1 |
| Mochizuki, S | 1 |
| Takayama, T | 1 |
| Yabe, H | 1 |
| Seki, S | 1 |
| Taniguchi, M | 1 |
| Nagano, M | 1 |
| Romics, L | 1 |
| Littmann, L | 1 |
| László, Z | 1 |
| Fenyvesi, T | 1 |
| Cavallini, B | 1 |
| Spinolo, L | 1 |
| Guadagni, C | 1 |
| Spitali, G | 1 |
3 trials available for probucol and Arrhythmia
| Article | Year |
|---|---|
Electrocardiographic effects of probucol. A controlled prospective clinical trial.
Topics: Adult; Arrhythmias, Cardiac; Cholesterol, LDL; Clinical Trials as Topic; Electrocardiography; Humans | 1984 |
Prolongation of the QT interval induced by probucol: demonstration of a method for determining QT interval change induced by a drug.
Topics: Adult; Arrhythmias, Cardiac; Cholesterol; Double-Blind Method; Electrocardiography; Female; Heart Ra | 1984 |
Nine years of treatment with probucol.
Topics: Arrhythmias, Cardiac; Cholesterol; Clinical Trials as Topic; Double-Blind Method; Electrocardiograph | 1982 |
4 other studies available for probucol and Arrhythmia
| Article | Year |
|---|---|
Probucol and the QT interval.
Topics: Arrhythmias, Cardiac; Electrocardiography; Heart; Humans; Phenols; Probucol | 1982 |
Protective effect of probucol on ischemia-reperfusion arrhythmias in the rat heart.
Topics: Animals; Arrhythmias, Cardiac; Blood Flow Velocity; Cholesterol, HDL; Drug Evaluation, Preclinical; | 1992 |
The effects of probucol on QT/QS2 relation and systolic time intervals.
Topics: Adult; Arrhythmias, Cardiac; Cardiac Output; Cholesterol; Electrocardiography; Female; Humans; Hyper | 1988 |
[Probucol and malignant ventricular arrhythmias. Presentation of a case].
Topics: Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Middle Aged; Phenols; Probucol; Syncope | 1987 |