probucol has been researched along with Antiphospholipid Syndrome in 1 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Antiphospholipid Syndrome: The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pathogenesis of antiphospholipid antibody (aPL) related thrombosis is multifactorial and includes, amongst others, enhanced coagulation activation measured as prothrombin fragment 1 + 2 (F1 + 2), elevated plasma levels of von Willebrand factor (vWF), plasminogen activator inhibitor (PAI) and endothelin-1 (ET-1) as well as heightened thromboxane generation and lipid peroxidation." | 5.09 | Antioxidant susceptibility of pathogenic pathways in subjects with antiphospholipid antibodies: a pilot study. ( Alves, J; Ames, PR; Brancaccio, V; Caccavo, F; Caruso, S; Fossati, G; Iannaccone, L; Morrow, JD; Tommasino, C, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ames, PR | 1 |
| Tommasino, C | 1 |
| Alves, J | 1 |
| Morrow, JD | 1 |
| Iannaccone, L | 1 |
| Fossati, G | 1 |
| Caruso, S | 1 |
| Caccavo, F | 1 |
| Brancaccio, V | 1 |
1 trial available for probucol and Antiphospholipid Syndrome
| Article | Year |
|---|---|
Antioxidant susceptibility of pathogenic pathways in subjects with antiphospholipid antibodies: a pilot study.
Topics: Adult; Albuminuria; Antibodies, Antiphospholipid; Anticholesteremic Agents; Anticoagulants; Antioxid | 2000 |