probucol has been researched along with Akinetic-Rigid Variant of Huntington Disease in 3 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our data suggest that the two studied toxic models (QA and 3-NP) or the combined model (QA plus 3-NP) can generate complex patterns of damage, which involve metabolic compromise, ROS formation, and oxidative stress." | 1.38 | Probucol modulates oxidative stress and excitotoxicity in Huntington's disease models in vitro. ( Colle, D; Farina, M; Hartwig, JM; Soares, FA, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Paula Nascimento-Castro, C | 1 |
| Wink, AC | 1 |
| da Fônseca, VS | 1 |
| Bianco, CD | 1 |
| Winkelmann-Duarte, EC | 1 |
| Farina, M | 3 |
| Rodrigues, ALS | 1 |
| Gil-Mohapel, J | 1 |
| de Bem, AF | 1 |
| Brocardo, PS | 1 |
| Colle, D | 2 |
| Santos, DB | 1 |
| Moreira, EL | 1 |
| Hartwig, JM | 2 |
| dos Santos, AA | 1 |
| Zimmermann, LT | 1 |
| Hort, MA | 1 |
| Soares, FA | 1 |
3 other studies available for probucol and Akinetic-Rigid Variant of Huntington Disease
| Article | Year |
|---|---|
Antidepressant Effects of Probucol on Early-Symptomatic YAC128 Transgenic Mice for Huntington's Disease.
Topics: Animals; Antidepressive Agents; Antioxidants; Cell Differentiation; Cell Proliferation; Cholesterol; | 2018 |
Probucol increases striatal glutathione peroxidase activity and protects against 3-nitropropionic acid-induced pro-oxidative damage in rats.
Topics: Animals; Antioxidants; Catalase; Corpus Striatum; Drug Evaluation, Preclinical; Electron Transport C | 2013 |
Probucol modulates oxidative stress and excitotoxicity in Huntington's disease models in vitro.
Topics: Animals; Antioxidants; Convulsants; Corpus Striatum; Disease Models, Animal; Huntington Disease; Lip | 2012 |