probucol has been researched along with Aging in 8 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study, we compared the effects of alpha-tocopherol and probucol, antioxidants, on the healing of acetic acid-induced gastric ulcers in 8-, 48- and 96-week-old rats." | 7.74 | Influence of aging on gastric ulcer healing activities of the antioxidants alpha-tocopherol and probucol. ( Ishihara, M; Ito, M; Kojima, R, 2008) |
| " In this study, serum lipid profiles and heart protective effects were evaluated in high fat diet (HFD) induced hyperlipidemia in aging rats treated with APPH (15, 45 and 75 mg/kg/day) and probucol (500 mg/kg/day)." | 3.81 | The Heart Protection Effect of Alcalase Potato Protein Hydrolysate Is through IGF1R-PI3K-Akt Compensatory Reactivation in Aging Rats on High Fat Diets. ( Chang, CH; Chiang, WD; Hu, WS; Huang, CY; Lin, WT; Pai, P; Ting, WJ; Yeh, YL, 2015) |
| "In the present study, we compared the effects of alpha-tocopherol and probucol, antioxidants, on the healing of acetic acid-induced gastric ulcers in 8-, 48- and 96-week-old rats." | 3.74 | Influence of aging on gastric ulcer healing activities of the antioxidants alpha-tocopherol and probucol. ( Ishihara, M; Ito, M; Kojima, R, 2008) |
| "High-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) poses therapeutic challenges in elderly subjects." | 1.48 | Bioactive Peptide Improves Diet-Induced Hepatic Fat Deposition and Hepatocyte Proinflammatory Response in SAMP8 Ageing Mice. ( Dumeus, S; Huang, CY; Kuo, WW; Lai, CH; Lin, WT; Lin, YM; Shen, CY; Shibu, MA; Viswanadha, VP; Wang, MF, 2018) |
| "Probucol is a non-Statin cholesterol-lowering drug and a potent inducer of apolipoprotein E (apoE) production in peripheral circulation." | 1.32 | The cholesterol-lowering drug probucol increases apolipoprotein E production in the hippocampus of aged rats: implications for Alzheimer's disease. ( Champagne, D; Dea, D; Pearson, D; Poirier, J; Rochford, J, 2003) |
| "Focal segmental glomerulosclerosis is a steroid-resistant glomerular disease characterized by foot process flattening and heavy proteinuria." | 1.30 | Glomerular overproduction of oxygen radicals in Mpv17 gene-inactivated mice causes podocyte foot process flattening and proteinuria: A model of steroid-resistant nephrosis sensitive to radical scavenger therapy. ( Binder, CJ; Exner, M; Kerjaschki, D; Weiher, H, 1999) |
| "Probucol (1%) was ineffective." | 1.29 | Antioxidant MDL 29,311 prevents diabetes in nonobese diabetic and multiple low-dose STZ-injected mice. ( Dillberger, JE; Heineke, EW; Johnson, MB; Robinson, KM, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dumeus, S | 1 |
| Shibu, MA | 1 |
| Lin, WT | 2 |
| Wang, MF | 1 |
| Lai, CH | 1 |
| Shen, CY | 1 |
| Lin, YM | 1 |
| Viswanadha, VP | 1 |
| Kuo, WW | 1 |
| Huang, CY | 2 |
| Hu, WS | 1 |
| Ting, WJ | 1 |
| Chiang, WD | 1 |
| Pai, P | 1 |
| Yeh, YL | 1 |
| Chang, CH | 1 |
| Ishihara, M | 1 |
| Kojima, R | 1 |
| Ito, M | 1 |
| Champagne, D | 1 |
| Pearson, D | 1 |
| Dea, D | 1 |
| Rochford, J | 1 |
| Poirier, J | 1 |
| Heineke, EW | 1 |
| Johnson, MB | 1 |
| Dillberger, JE | 1 |
| Robinson, KM | 1 |
| Binder, CJ | 1 |
| Weiher, H | 1 |
| Exner, M | 1 |
| Kerjaschki, D | 1 |
| Uehara, Y | 1 |
| Shimizu, H | 1 |
| Sato, N | 1 |
| Shimomura, Y | 1 |
| Mori, M | 1 |
| Kobayashi, I | 1 |
| Mori, Y | 1 |
| Wada, H | 1 |
| Nagano, Y | 1 |
| Deguchi, K | 1 |
| Kita, T | 1 |
| Shirakawa, S | 1 |
8 other studies available for probucol and Aging
| Article | Year |
|---|---|
Bioactive Peptide Improves Diet-Induced Hepatic Fat Deposition and Hepatocyte Proinflammatory Response in SAMP8 Ageing Mice.
Topics: Aging; Amino Acid Sequence; AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Forkhead Box Pro | 2018 |
The Heart Protection Effect of Alcalase Potato Protein Hydrolysate Is through IGF1R-PI3K-Akt Compensatory Reactivation in Aging Rats on High Fat Diets.
Topics: Aging; Animals; Anticholesteremic Agents; Apoptosis; Cardiotonic Agents; Cholesterol; Diet, High-Fat | 2015 |
Influence of aging on gastric ulcer healing activities of the antioxidants alpha-tocopherol and probucol.
Topics: Acetic Acid; Administration, Oral; Aging; alpha-Tocopherol; Animals; Anti-Ulcer Agents; Antioxidants | 2008 |
The cholesterol-lowering drug probucol increases apolipoprotein E production in the hippocampus of aged rats: implications for Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Animals; Apolipoproteins E; Cholesterol; Hippocampus; Male; Probucol; Rats | 2003 |
Antioxidant MDL 29,311 prevents diabetes in nonobese diabetic and multiple low-dose STZ-injected mice.
Topics: Aging; Animals; Antioxidants; Atrophy; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mell | 1993 |
Glomerular overproduction of oxygen radicals in Mpv17 gene-inactivated mice causes podocyte foot process flattening and proteinuria: A model of steroid-resistant nephrosis sensitive to radical scavenger therapy.
Topics: Aging; Albuminuria; Animals; Disease Models, Animal; Free Radical Scavengers; Glomerulosclerosis, Fo | 1999 |
Probucol partially prevents development of diabetes in NOD mice.
Topics: Aging; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diet; Female; Flow Cytometry; Glycos | 1991 |
Hypercoagulable state in the Watanabe heritable hyperlipidemic rabbit, an animal model for the progression of atherosclerosis. Effect of probucol on coagulation.
Topics: Aging; Animals; Arteriosclerosis; Blood Coagulation Factors; Disease Models, Animal; Hyperlipidemias | 1989 |