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probucol and Aging

probucol has been researched along with Aging in 8 studies

Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"In the present study, we compared the effects of alpha-tocopherol and probucol, antioxidants, on the healing of acetic acid-induced gastric ulcers in 8-, 48- and 96-week-old rats."7.74Influence of aging on gastric ulcer healing activities of the antioxidants alpha-tocopherol and probucol. ( Ishihara, M; Ito, M; Kojima, R, 2008)
" In this study, serum lipid profiles and heart protective effects were evaluated in high fat diet (HFD) induced hyperlipidemia in aging rats treated with APPH (15, 45 and 75 mg/kg/day) and probucol (500 mg/kg/day)."3.81The Heart Protection Effect of Alcalase Potato Protein Hydrolysate Is through IGF1R-PI3K-Akt Compensatory Reactivation in Aging Rats on High Fat Diets. ( Chang, CH; Chiang, WD; Hu, WS; Huang, CY; Lin, WT; Pai, P; Ting, WJ; Yeh, YL, 2015)
"In the present study, we compared the effects of alpha-tocopherol and probucol, antioxidants, on the healing of acetic acid-induced gastric ulcers in 8-, 48- and 96-week-old rats."3.74Influence of aging on gastric ulcer healing activities of the antioxidants alpha-tocopherol and probucol. ( Ishihara, M; Ito, M; Kojima, R, 2008)
"High-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) poses therapeutic challenges in elderly subjects."1.48Bioactive Peptide Improves Diet-Induced Hepatic Fat Deposition and Hepatocyte Proinflammatory Response in SAMP8 Ageing Mice. ( Dumeus, S; Huang, CY; Kuo, WW; Lai, CH; Lin, WT; Lin, YM; Shen, CY; Shibu, MA; Viswanadha, VP; Wang, MF, 2018)
"Probucol is a non-Statin cholesterol-lowering drug and a potent inducer of apolipoprotein E (apoE) production in peripheral circulation."1.32The cholesterol-lowering drug probucol increases apolipoprotein E production in the hippocampus of aged rats: implications for Alzheimer's disease. ( Champagne, D; Dea, D; Pearson, D; Poirier, J; Rochford, J, 2003)
"Focal segmental glomerulosclerosis is a steroid-resistant glomerular disease characterized by foot process flattening and heavy proteinuria."1.30Glomerular overproduction of oxygen radicals in Mpv17 gene-inactivated mice causes podocyte foot process flattening and proteinuria: A model of steroid-resistant nephrosis sensitive to radical scavenger therapy. ( Binder, CJ; Exner, M; Kerjaschki, D; Weiher, H, 1999)
"Probucol (1%) was ineffective."1.29Antioxidant MDL 29,311 prevents diabetes in nonobese diabetic and multiple low-dose STZ-injected mice. ( Dillberger, JE; Heineke, EW; Johnson, MB; Robinson, KM, 1993)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's3 (37.50)18.2507
2000's2 (25.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dumeus, S1
Shibu, MA1
Lin, WT2
Wang, MF1
Lai, CH1
Shen, CY1
Lin, YM1
Viswanadha, VP1
Kuo, WW1
Huang, CY2
Hu, WS1
Ting, WJ1
Chiang, WD1
Pai, P1
Yeh, YL1
Chang, CH1
Ishihara, M1
Kojima, R1
Ito, M1
Champagne, D1
Pearson, D1
Dea, D1
Rochford, J1
Poirier, J1
Heineke, EW1
Johnson, MB1
Dillberger, JE1
Robinson, KM1
Binder, CJ1
Weiher, H1
Exner, M1
Kerjaschki, D1
Uehara, Y1
Shimizu, H1
Sato, N1
Shimomura, Y1
Mori, M1
Kobayashi, I1
Mori, Y1
Wada, H1
Nagano, Y1
Deguchi, K1
Kita, T1
Shirakawa, S1

Other Studies

8 other studies available for probucol and Aging

ArticleYear
Bioactive Peptide Improves Diet-Induced Hepatic Fat Deposition and Hepatocyte Proinflammatory Response in SAMP8 Ageing Mice.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 48, Issue:5

    Topics: Aging; Amino Acid Sequence; AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Forkhead Box Pro

2018
The Heart Protection Effect of Alcalase Potato Protein Hydrolysate Is through IGF1R-PI3K-Akt Compensatory Reactivation in Aging Rats on High Fat Diets.
    International journal of molecular sciences, 2015, May-05, Volume: 16, Issue:5

    Topics: Aging; Animals; Anticholesteremic Agents; Apoptosis; Cardiotonic Agents; Cholesterol; Diet, High-Fat

2015
Influence of aging on gastric ulcer healing activities of the antioxidants alpha-tocopherol and probucol.
    European journal of pharmacology, 2008, Dec-28, Volume: 601, Issue:1-3

    Topics: Acetic Acid; Administration, Oral; Aging; alpha-Tocopherol; Animals; Anti-Ulcer Agents; Antioxidants

2008
The cholesterol-lowering drug probucol increases apolipoprotein E production in the hippocampus of aged rats: implications for Alzheimer's disease.
    Neuroscience, 2003, Volume: 121, Issue:1

    Topics: Aging; Alzheimer Disease; Animals; Apolipoproteins E; Cholesterol; Hippocampus; Male; Probucol; Rats

2003
Antioxidant MDL 29,311 prevents diabetes in nonobese diabetic and multiple low-dose STZ-injected mice.
    Diabetes, 1993, Volume: 42, Issue:12

    Topics: Aging; Animals; Antioxidants; Atrophy; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mell

1993
Glomerular overproduction of oxygen radicals in Mpv17 gene-inactivated mice causes podocyte foot process flattening and proteinuria: A model of steroid-resistant nephrosis sensitive to radical scavenger therapy.
    The American journal of pathology, 1999, Volume: 154, Issue:4

    Topics: Aging; Albuminuria; Animals; Disease Models, Animal; Free Radical Scavengers; Glomerulosclerosis, Fo

1999
Probucol partially prevents development of diabetes in NOD mice.
    Diabetes research (Edinburgh, Scotland), 1991, Volume: 17, Issue:3

    Topics: Aging; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diet; Female; Flow Cytometry; Glycos

1991
Hypercoagulable state in the Watanabe heritable hyperlipidemic rabbit, an animal model for the progression of atherosclerosis. Effect of probucol on coagulation.
    Thrombosis and haemostasis, 1989, Feb-28, Volume: 61, Issue:1

    Topics: Aging; Animals; Arteriosclerosis; Blood Coagulation Factors; Disease Models, Animal; Hyperlipidemias

1989