probucol has been researched along with Age-Related Osteoporosis in 2 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Probucol (PBC) is a potent cholesterol-lowering drug and has been studied extensively for its powerful antioxidative stress." | 5.72 | Probucol promotes osteoblasts differentiation and prevents osteoporosis development through reducing oxidative stress. ( Li, TL; Tao, ZS; Wei, S, 2022) |
| "However, treatment of osteoporosis is far from satisfactory due to poor adherence to existing medications and adverse reactions, there is an urgent to develop novel therapies for osteoporosis." | 1.91 | Probucol suppresses osteoclastogenesis via activating Nrf2 signaling and ameliorates ovariectomy-induced bone loss. ( Guo, J; Guo, Z; He, J; Ren, R; Shao, J; Sun, K; Wang, X, 2023) |
| "Probucol (PBC) is a potent cholesterol-lowering drug and has been studied extensively for its powerful antioxidative stress." | 1.72 | Probucol promotes osteoblasts differentiation and prevents osteoporosis development through reducing oxidative stress. ( Li, TL; Tao, ZS; Wei, S, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tao, ZS | 1 |
| Li, TL | 1 |
| Wei, S | 1 |
| Guo, J | 1 |
| Ren, R | 1 |
| Guo, Z | 1 |
| Sun, K | 1 |
| He, J | 1 |
| Shao, J | 1 |
| Wang, X | 1 |
2 other studies available for probucol and Age-Related Osteoporosis
| Article | Year |
|---|---|
Probucol promotes osteoblasts differentiation and prevents osteoporosis development through reducing oxidative stress.
Topics: Animals; Osteoblasts; Osteogenesis; Osteoporosis; Oxidative Stress; Probucol; Rats | 2022 |
Probucol suppresses osteoclastogenesis via activating Nrf2 signaling and ameliorates ovariectomy-induced bone loss.
Topics: Antioxidants; Bone Resorption; Cell Differentiation; Female; Humans; NF-E2-Related Factor 2; NF-kapp | 2023 |