probenecid has been researched along with Uremia in 16 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "CKD mice exhibited marked left ventricular hypertrophy and myocardial fibrosis, which were reversed by treatment with the CB1R antagonist." | 1.42 | CB1 cannabinoid receptor antagonist attenuates left ventricular hypertrophy and Akt-mediated cardiac fibrosis in experimental uremia. ( Chen, Y; Hsu, SC; Hsu, YJ; Huang, SM; Lee, HS; Lin, CY; Lin, SH; Shih, CC; Tsai, CS, 2015) |
| "Acute renal failure was induced by occlusion of bilateral renal arteries for 60 min, and the motor activity and brain monoamine turnover were examined 48 h later." | 1.31 | Uraemia suppresses central dopaminergic metabolism and impairs motor activity in rats. ( Adachi, N; Arai, T; Deshpande, G; Lei, B; Nagaro, T; Seyfried, FJ; Shimizu, I, 2001) |
| "The subjects with encephalopathy had raised plasma free tryptophan, CSF tryptophan, and CSF 5-hydroxyindoleacetic acid." | 1.26 | Cerebral transmitter precursors and metabolites in advanced renal disease. ( Callaghan, N; Curzon, G; Kantamaneni, BD; Murnaghan, D; Sullivan, PA, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (43.75) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Favretto, G | 1 |
| Souza, LM | 1 |
| Gregório, PC | 1 |
| Cunha, RS | 1 |
| Maciel, RAP | 1 |
| Sassaki, GL | 1 |
| Toledo, MG | 1 |
| Pecoits-Filho, R | 1 |
| Souza, WM | 1 |
| Stinghen, AEM | 1 |
| Jhawar, S | 1 |
| Singh, P | 1 |
| Torres, D | 1 |
| Ramirez-Valle, F | 1 |
| Kassem, H | 1 |
| Banerjee, T | 1 |
| Dolgalev, I | 1 |
| Heguy, A | 1 |
| Zavadil, J | 1 |
| Lowenstein, J | 1 |
| Lin, CY | 1 |
| Hsu, YJ | 1 |
| Hsu, SC | 1 |
| Chen, Y | 1 |
| Lee, HS | 1 |
| Lin, SH | 1 |
| Huang, SM | 1 |
| Tsai, CS | 1 |
| Shih, CC | 1 |
| Liu, S | 1 |
| Wang, BH | 1 |
| Kompa, AR | 1 |
| Lekawanvijit, S | 1 |
| Krum, H | 1 |
| FRITZE, E | 1 |
| MUELLER, HO | 1 |
| BATT, RE | 1 |
| CIRKSENA, WJ | 1 |
| LEBHERZ, TB | 1 |
| Bollet, AJ | 1 |
| Costigan, MG | 1 |
| Lindup, WE | 1 |
| Lhotta, K | 1 |
| Gruber, J | 1 |
| Sgonc, R | 1 |
| Fend, F | 1 |
| König, P | 1 |
| Adachi, N | 1 |
| Lei, B | 1 |
| Deshpande, G | 1 |
| Seyfried, FJ | 1 |
| Shimizu, I | 1 |
| Nagaro, T | 1 |
| Arai, T | 1 |
| Deguchi, T | 1 |
| Ohtsuki, S | 1 |
| Otagiri, M | 1 |
| Takanaga, H | 1 |
| Asaba, H | 1 |
| Mori, S | 1 |
| Terasaki, T | 1 |
| Sullivan, PA | 1 |
| Murnaghan, D | 1 |
| Callaghan, N | 1 |
| Kantamaneni, BD | 1 |
| Curzon, G | 1 |
| Mann, JD | 1 |
| Bass, NH | 1 |
| Wolfe, F | 1 |
| Cathey, MA | 1 |
| Garyfallos, A | 1 |
| Magoula, I | 1 |
| Tsapas, G | 1 |
| Grantham, JJ | 1 |
| Irwin, RL | 1 |
| Qualizza, PB | 1 |
| Tucker, DR | 1 |
| Whittier, FC | 1 |
16 other studies available for probenecid and Uremia
| Article | Year |
|---|---|
Role of Organic Anion Transporters in the Uptake of Protein-Bound Uremic Toxins by Human Endothelial Cells and Monocyte Chemoattractant Protein-1 Expression.
Topics: Biological Transport; Cell Line; Cell Survival; Chemokine CCL2; Cresols; Dose-Response Relationship, | 2017 |
Functional genomic analysis identifies indoxyl sulfate as a major, poorly dialyzable uremic toxin in end-stage renal disease.
Topics: Adult; Aged; Animals; Cell Line; Chromatography, High Pressure Liquid; Culture Media; Female; Gene E | 2015 |
CB1 cannabinoid receptor antagonist attenuates left ventricular hypertrophy and Akt-mediated cardiac fibrosis in experimental uremia.
Topics: Animals; Cannabinoid Receptor Antagonists; Cell Line; Collagen; Drug Evaluation, Preclinical; Fibros | 2015 |
Antagonists of organic anion transporters 1 and 3 ameliorate adverse cardiac remodelling induced by uremic toxin indoxyl sulfate.
Topics: Animals; Cells, Cultured; Cilastatin; Fibroblasts; Indican; Myocytes, Cardiac; Organic Anion Transpo | 2012 |
[On probenecid treatment of chronic gout. Report of a severe complication of treatment].
Topics: Arthritis, Gouty; Chronic Disease; Gout; Humans; Probenecid; Uremia | 1962 |
GOUT AND SALT-WASTING RENAL DISEASE DURING PREGNANCY; DIAGNOSIS, MANAGEMENT, AND FOLLOW-UP.
Topics: Blood Chemical Analysis; Colchicine; Diet Therapy; Diet, Sodium-Restricted; Female; Follow-Up Studie | 1963 |
Diagnostic and therapeutic aids in gout and hyperuricemia.
Topics: Acute Disease; Allopurinol; Arthritis, Rheumatoid; Colchicine; Diagnosis, Differential; Gout; Humans | 1981 |
Plasma clearance in the rat of a furan dicarboxylic acid which accumulates in uremia.
Topics: Animals; Female; Furans; Infusions, Intravenous; p-Aminohippuric Acid; Probenecid; Propionates; Rats | 1996 |
Apoptosis of tubular epithelial cells in familial juvenile gouty nephropathy.
Topics: Adult; Apoptosis; Benzbromarone; Biopsy; Biotin; Deoxyuracil Nucleotides; DNA Fragmentation; Family | 1998 |
Uraemia suppresses central dopaminergic metabolism and impairs motor activity in rats.
Topics: Acute Kidney Injury; alpha-Methyltyrosine; Animals; Brain Chemistry; Coma; Confusion; Corpus Striatu | 2001 |
Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.
Topics: Animals; Anions; Biological Transport; Dose-Response Relationship, Drug; Female; Furans; Indican; Ki | 2002 |
Cerebral transmitter precursors and metabolites in advanced renal disease.
Topics: Adult; Aged; Brain; Brain Diseases; Fatty Acids, Nonesterified; Female; Homovanillic Acid; Humans; H | 1978 |
Acute uremic encephalopathy in the rat: defective sink action of the cerebrospinal fluid for acid metabolites.
Topics: Aminohippuric Acids; Animals; Inulin; Probenecid; Rats; Uremia | 1975 |
The misdiagnosis of gout and hyperuricemia.
Topics: Adult; Aged; Allopurinol; Analysis of Variance; Arthritis, Psoriatic; Chondrocalcinosis; Colchicine; | 1991 |
Evaluation of the renal mechanisms for urate homeostasis in uremic patients by probenecid and pyrazinamide test.
Topics: Absorption; Creatinine; Female; Glomerular Filtration Rate; Gout; Homeostasis; Humans; Kidney Failur | 1987 |
Fluid secretion in isolated proximal straight renal tubules. Effect of human uremic serum.
Topics: Acetates; Aminohippuric Acids; Animals; Benzoates; Blood Urea Nitrogen; Creatinine; Female; Guanidin | 1973 |