probenecid has been researched along with Syphilis in 43 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Syphilis: A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This is the first randomized controlled trial to demonstrate a high efficacy of amoxicillin-based regimens for treating syphilis in patients with HIV infection, and the non-inferiority of low-dose amoxicillin compared with amoxicillin plus probenecid was not seen." | 9.69 | Combination of Amoxicillin 3000 mg and Probenecid Versus 1500 mg Amoxicillin Monotherapy for Treating Syphilis in Patients With Human Immunodeficiency Virus: An Open-Label, Randomized, Controlled, Non-Inferiority Trial. ( Ando, N; Aoki, T; Gatanaga, H; Hiramoto, S; Inamura, N; Kikuchi, Y; Mizushima, D; Nemoto, T; Oka, S; Omata, K; Shiojiri, D; Takano, M; Tanuma, J; Teruya, K; Uemura, H; Watanabe, K; Yanagawa, Y, 2023) |
| " In a previous report, 3 g/day amoxicillin with probenecid was shown to be effective in treating syphilis in patients with HIV; however, 7." | 8.12 | Clinical efficacy and tolerability of 1.5 g/day oral amoxicillin therapy without probenecid for the treatment of syphilis. ( Fukushima, K; Ikeuchi, K; Imamura, A; Tanaka, M; Yajima, K, 2022) |
| "This retrospective observational study included 286 HIV-infected male patients with syphilis (median age, 36 years; median CD4 count, 389 cells/µL) who were treated with oral amoxicillin 3 g plus probenecid." | 7.81 | High-dose oral amoxicillin plus probenecid is highly effective for syphilis in patients with HIV infection. ( Aoki, T; Gatanaga, H; Kikuchi, Y; Nishijima, T; Oka, S; Tanizaki, R; Teruya, K, 2015) |
| "This is the first randomized controlled trial to demonstrate a high efficacy of amoxicillin-based regimens for treating syphilis in patients with HIV infection, and the non-inferiority of low-dose amoxicillin compared with amoxicillin plus probenecid was not seen." | 5.69 | Combination of Amoxicillin 3000 mg and Probenecid Versus 1500 mg Amoxicillin Monotherapy for Treating Syphilis in Patients With Human Immunodeficiency Virus: An Open-Label, Randomized, Controlled, Non-Inferiority Trial. ( Ando, N; Aoki, T; Gatanaga, H; Hiramoto, S; Inamura, N; Kikuchi, Y; Mizushima, D; Nemoto, T; Oka, S; Omata, K; Shiojiri, D; Takano, M; Tanuma, J; Teruya, K; Uemura, H; Watanabe, K; Yanagawa, Y, 2023) |
| "In addition, syphilis is not just a genital disease." | 5.62 | [A case of early syphilitic hepatitis with jaundice cured by high-dose amoxicillin and probenecid]. ( Kobayashi, W; Kojima, E; Kuba, H; Matsumura, M, 2021) |
| " Controls over a 15-weeks period showed that this dosage did prevent the development of syphilitic orchitis and reactivity to the quantitative FTA-ABS-test." | 5.25 | [The effect of pivampicillin and probenecid on experimental syphilis in rabbits]. ( Petzoldt, D, 1975) |
| " In a previous report, 3 g/day amoxicillin with probenecid was shown to be effective in treating syphilis in patients with HIV; however, 7." | 4.12 | Clinical efficacy and tolerability of 1.5 g/day oral amoxicillin therapy without probenecid for the treatment of syphilis. ( Fukushima, K; Ikeuchi, K; Imamura, A; Tanaka, M; Yajima, K, 2022) |
| "This retrospective observational study included 286 HIV-infected male patients with syphilis (median age, 36 years; median CD4 count, 389 cells/µL) who were treated with oral amoxicillin 3 g plus probenecid." | 3.81 | High-dose oral amoxicillin plus probenecid is highly effective for syphilis in patients with HIV infection. ( Aoki, T; Gatanaga, H; Kikuchi, Y; Nishijima, T; Oka, S; Tanizaki, R; Teruya, K, 2015) |
| "The current recommendations for treating early syphilis appear adequate for most patients, whether or not they have HIV infection." | 2.68 | A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group. ( Augenbraun, MH; Bolan, G; Chiu, M; French, P; Hendershot, EF; Joesoef, MR; Johnson, SC; Larsen, S; Radolf, JD; Rolfs, RT; Rompalo, AM; Steen, E, 1997) |
| "Traditional treatment of otosyphilis with penicillin and corticosteroids has achieved hearing improvement; however, selecting which patients with a positive fluorescent treponemal antibody absorption (FTA-ABS) test will benefit from treatment remains a problem." | 2.67 | Otosyphilis: a diagnostic and therapeutic dilemma. ( Gleich, LL; Kimmelman, CP; Linstrom, CJ, 1992) |
| "Recommendations for treatment of syphilis remain the same for patients with and without HIV." | 2.42 | Syphilis in the HIV-infected patient: an update on epidemiology, diagnosis, and management. ( Augenbraun, M; Zellan, J, 2004) |
| "In addition, syphilis is not just a genital disease." | 1.62 | [A case of early syphilitic hepatitis with jaundice cured by high-dose amoxicillin and probenecid]. ( Kobayashi, W; Kojima, E; Kuba, H; Matsumura, M, 2021) |
| "Syphilis is a treatable condition, screening in pregnancy is both cost effective and cost beneficial." | 1.35 | Stroke in pregnancy associated with syphilis. ( Baker, PN; Bowring, J; Mahto, M; Mandal, D, 2008) |
| "Our case is original because papillitis was the presenting manifestation of the disease and that it was concomitant with the primary chancre." | 1.34 | [A case of papillitis revealing primary syphilis]. ( B'chir Hamzaoui, S; Ben Dridi, M; Bouslama, K; Farah, H; Znagui, Z, 2007) |
| "Regimens accepted for the treatment of neurosyphilis appear to be adequate for the treatment of ocular syphilis in HIV-1-infected patients though further long-term follow-up will be required." | 1.28 | The ocular manifestations of syphilis in the human immunodeficiency virus type 1-infected host. ( Culbertson, WW; Holland, S; McLeish, WM; Pulido, JS; Winward, K, 1990) |
| " Controls over a 15-weeks period showed that this dosage did prevent the development of syphilitic orchitis and reactivity to the quantitative FTA-ABS-test." | 1.25 | [The effect of pivampicillin and probenecid on experimental syphilis in rabbits]. ( Petzoldt, D, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (65.12) | 18.7374 |
| 1990's | 5 (11.63) | 18.2507 |
| 2000's | 5 (11.63) | 29.6817 |
| 2010's | 1 (2.33) | 24.3611 |
| 2020's | 4 (9.30) | 2.80 |
| Authors | Studies |
|---|---|
| Richardson, D | 1 |
| Goldmeier, D | 2 |
| Ando, N | 1 |
| Mizushima, D | 1 |
| Omata, K | 1 |
| Nemoto, T | 1 |
| Inamura, N | 1 |
| Hiramoto, S | 1 |
| Takano, M | 1 |
| Aoki, T | 2 |
| Watanabe, K | 1 |
| Uemura, H | 1 |
| Shiojiri, D | 1 |
| Yanagawa, Y | 1 |
| Tanuma, J | 1 |
| Teruya, K | 2 |
| Kikuchi, Y | 2 |
| Gatanaga, H | 2 |
| Oka, S | 2 |
| Kobayashi, W | 1 |
| Matsumura, M | 1 |
| Kuba, H | 1 |
| Kojima, E | 1 |
| Ikeuchi, K | 1 |
| Fukushima, K | 1 |
| Tanaka, M | 1 |
| Yajima, K | 1 |
| Imamura, A | 1 |
| Tanizaki, R | 1 |
| Nishijima, T | 1 |
| Bowring, J | 1 |
| Mahto, M | 1 |
| Mandal, D | 1 |
| Baker, PN | 1 |
| Warwick, Z | 1 |
| Dean, G | 1 |
| Fisher, M | 1 |
| Hartmann, M | 1 |
| Zellan, J | 1 |
| Augenbraun, M | 2 |
| B'chir Hamzaoui, S | 1 |
| Znagui, Z | 1 |
| Farah, H | 1 |
| Bouslama, K | 1 |
| Ben Dridi, M | 1 |
| Goh, BT | 1 |
| Smith, GW | 1 |
| Samarasinghe, L | 1 |
| Singh, V | 1 |
| Lim, KS | 1 |
| Belin, MW | 1 |
| Baltch, AL | 1 |
| Hay, PB | 1 |
| Polnikorn, N | 2 |
| Witoonpanich, R | 2 |
| Vorachit, M | 2 |
| Vejjajiva, S | 2 |
| Vejjajiva, A | 2 |
| Rolfs, RT | 1 |
| Joesoef, MR | 1 |
| Hendershot, EF | 1 |
| Rompalo, AM | 1 |
| Augenbraun, MH | 1 |
| Chiu, M | 1 |
| Bolan, G | 1 |
| Johnson, SC | 1 |
| French, P | 1 |
| Steen, E | 1 |
| Radolf, JD | 1 |
| Larsen, S | 1 |
| Rolfs, R | 1 |
| Johnson, R | 1 |
| Joesoef, R | 1 |
| Pope, V | 1 |
| Anghelescu, M | 1 |
| Antonescu, S | 1 |
| Henderson, RH | 1 |
| Dunlop, EM | 1 |
| Al-Egaily, SS | 1 |
| Houang, ET | 1 |
| Jefferiss, FJ | 1 |
| Petzoldt, D | 2 |
| Gleich, LL | 1 |
| Linstrom, CJ | 1 |
| Kimmelman, CP | 1 |
| Hay, PE | 1 |
| Taylor-Robinson, D | 1 |
| Waldron, S | 1 |
| McLeish, WM | 1 |
| Pulido, JS | 1 |
| Holland, S | 1 |
| Culbertson, WW | 1 |
| Winward, K | 1 |
| van der Valk, PG | 1 |
| Kraai, EJ | 1 |
| van Voorst Vader, PC | 1 |
| Haaxma-Reiche, H | 1 |
| Snijder, JA | 1 |
| Dunaeva, GA | 1 |
| Gorisiuk, AF | 1 |
| Kletnoĭ, AG | 1 |
| Nazarova, AIu | 1 |
| Bednova, VN | 1 |
| Abashina, NIu | 1 |
| Arzamastsev, AP | 1 |
| Niordson, AM | 1 |
| Ullman, S | 1 |
| Hallinger, L | 1 |
| Rudolph, AH | 1 |
| Platts, WM | 1 |
| Sparling, PF | 1 |
| Shapiro, SR | 1 |
| Breschi, LC | 1 |
| Wilkinson, AE | 1 |
| Fleming, WL | 1 |
| Seale, JR | 1 |
| Lopez, WA | 1 |
| Gilliet, F | 1 |
| Storck, H | 1 |
| Christman, EH | 1 |
| Hamilton, RW | 1 |
| Heaton, CL | 1 |
| Hoffmeyer, IM | 1 |
| Foster, MT | 1 |
| Goldman, EE | 1 |
| McLain, JH | 1 |
| Smith, JL | 1 |
2 reviews available for probenecid and Syphilis
| Article | Year |
|---|---|
Syphilis in the HIV-infected patient: an update on epidemiology, diagnosis, and management.
Topics: Administration, Oral; AIDS-Related Opportunistic Infections; Amoxicillin; Clinical Trials as Topic; | 2004 |
[New developments in the treatment of venereal diseases].
Topics: Adult; Anaphylaxis; Chemical Phenomena; Chemistry; Female; Follow-Up Studies; Gonorrhea; Humans; Mal | 1974 |
7 trials available for probenecid and Syphilis
| Article | Year |
|---|---|
Combination of Amoxicillin 3000 mg and Probenecid Versus 1500 mg Amoxicillin Monotherapy for Treating Syphilis in Patients With Human Immunodeficiency Virus: An Open-Label, Randomized, Controlled, Non-Inferiority Trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Drug-Related Side Effects and Adverse Reactions; HIV; HIV Infect | 2023 |
A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group.
Topics: Adult; Amoxicillin; Double-Blind Method; Drug Therapy, Combination; Female; HIV Infections; Humans; | 1997 |
Treponemal specific tests for the serodiagnosis of syphilis. Syphilis and HIV Study Group.
Topics: Amoxicillin; Antibodies, Bacterial; Cohort Studies; Drug Therapy, Combination; Female; Fluorescent T | 1998 |
Otosyphilis: a diagnostic and therapeutic dilemma.
Topics: Adult; Aged; Amoxicillin; Cardiolipins; Cerebrospinal Fluid; Cholesterol; Clinical Protocols; Cochle | 1992 |
Amoxycillin, syphilis, and HIV infection.
Topics: Amoxicillin; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Drug Therapy, Combinati | 1990 |
Venereal disease: diagnosis and treatment.
Topics: Cephalosporins; Clinical Trials as Topic; Drug Combinations; Erythromycin; Female; Gonorrhea; Humans | 1973 |
Treatment of gonorrhea. Penicillin.
Topics: Ampicillin; Costs and Cost Analysis; Drug Hypersensitivity; Drug Synergism; Female; Genetics, Microb | 1973 |
34 other studies available for probenecid and Syphilis
| Article | Year |
|---|---|
Probenecid in the treatment of neurosyphilis in men who have sex with men: a commentary.
Topics: HIV Infections; Homosexuality, Male; Humans; Male; Neurosyphilis; Probenecid; Sexual and Gender Mino | 2022 |
[A case of early syphilitic hepatitis with jaundice cured by high-dose amoxicillin and probenecid].
Topics: Adult; Amoxicillin; Hepatitis; Humans; Jaundice; Male; Probenecid; Syphilis | 2021 |
Clinical efficacy and tolerability of 1.5 g/day oral amoxicillin therapy without probenecid for the treatment of syphilis.
Topics: Amoxicillin; Anti-Bacterial Agents; HIV Infections; Humans; Probenecid; Retrospective Studies; Syphi | 2022 |
High-dose oral amoxicillin plus probenecid is highly effective for syphilis in patients with HIV infection.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Bacterial Agents; CD4 Lymphocyte Count; Drug Therapy, | 2015 |
Stroke in pregnancy associated with syphilis.
Topics: Adult; Anti-Bacterial Agents; Aspirin; Female; Gestational Age; Humans; Magnetic Resonance Imaging; | 2008 |
Should syphilis be treated differently in HIV-positive and HIV-negative individuals? Treatment outcomes at a university hospital, Brighton, UK.
Topics: Administration, Oral; Anti-Bacterial Agents; Drug Administration Schedule; Drug Therapy, Combination | 2009 |
[Therapy of syphilis].
Topics: Adult; Anti-Bacterial Agents; Azithromycin; Ceftriaxone; Controlled Clinical Trials as Topic; Doxycy | 2004 |
[A case of papillitis revealing primary syphilis].
Topics: Adult; Chancre; Chorioretinitis; Facial Dermatoses; Humans; Male; Papilledema; Penicillins; Probenec | 2007 |
Penicillin concentrations in serum and cerebrospinal fluid after intramuscular injection of aqueous procaine penicillin 0.6 MU with and without probenecid.
Topics: Biological Assay; Drug Therapy, Combination; Female; Humans; Injections, Intramuscular; Male; Penici | 1984 |
Secondary syphilitic uveitis.
Topics: Aqueous Humor; Fluorescent Antibody Technique; Humans; Male; Middle Aged; Penicillin G; Probenecid; | 1981 |
Penicillin concentrations in the cerebrospinal fluid after benzathine penicillin and probenecid in the treatment of syphilis.
Topics: Drug Therapy, Combination; Humans; Male; Penicillin G Benzathine; Probenecid; Syphilis | 1982 |
Penicillin concentrations in cerebrospinal fluid after different treatment regimens for syphilis.
Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Penicillin G; Penicillin | 1980 |
[Experiences in the treatment of syphilis and gonorrhea].
Topics: Benzimidazoles; Evaluation Studies as Topic; Female; Gonorrhea; Humans; Male; Penicillin G Procaine; | 1976 |
Recommended treatment schedules for Gonorrhea--1974.
Topics: Ampicillin; Child; Female; Gonorrhea; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Pelv | 1975 |
Penicillin levels in blood and CSF achieved by treatment of syphilis.
Topics: Administration, Oral; Humans; Injections, Intramuscular; Penicillin G; Penicillin G Procaine; Penici | 1979 |
Venereal disease and the homosexual.
Topics: Ampicillin; Anus Diseases; Gonorrhea; Homosexuality; Humans; Male; Penicillin G Procaine; Probenecid | 1976 |
[The effect of pivampicillin and probenecid on experimental syphilis in rabbits].
Topics: Administration, Oral; Ampicillin; Animals; Disease Models, Animal; Drug Therapy, Combination; Humans | 1975 |
The ocular manifestations of syphilis in the human immunodeficiency virus type 1-infected host.
Topics: Adult; Central Nervous System Diseases; Doxycycline; Eye Diseases; Fundus Oculi; HIV Infections; HIV | 1990 |
Penicillin concentrations in cerebrospinal fluid (CSF) during repository treatment regimen for syphilis.
Topics: Drug Therapy, Combination; Humans; Neurosyphilis; Penicillin G; Penicillin G Procaine; Probenecid; S | 1988 |
[Effect of etamid on penicillin levels of the blood serum and cerebrospinal fluid of syphilis patients].
Topics: Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Humans; Male; P | 1987 |
[Effect of probenecid and etamid on the penicillin levels of the blood serum and cerebrospinal fluid in experimental animals].
Topics: Animals; Biological Availability; Drug Evaluation, Preclinical; Drug Interactions; Drug Therapy, Com | 1985 |
Treatment of gonorrhoea with aqueous benzyl penicillin plus probenecid.
Topics: Adolescent; Adult; Drug Hypersensitivity; Female; Follow-Up Studies; Gonorrhea; Humans; Injections, | 1971 |
Experimental under-treatment of early syphilis with probenecid and penicillin in anti-gonorrhoea dosages. A study to assess the best follow-up examination time for syphilis after gonorrhoea treatment in Greenland.
Topics: Adult; Female; Gonorrhea; Greenland; Health Surveys; Humans; Male; Penicillin G; Probenecid; Syphili | 1968 |
Control of gonorrhea. Guidelines for antibiotic treatment.
Topics: Administration, Oral; Ampicillin; Anti-Bacterial Agents; Female; Gonorrhea; Humans; Injections, Intr | 1972 |
Venereal disease in Vietnam: clinical experience at a major military hospital.
Topics: Aerospace Medicine; Anti-Bacterial Agents; Benzalkonium Compounds; Chancroid; Condylomata Acuminata; | 1974 |
Problems in the treatment of venereal disease: bacterial resistance: allergy.
Topics: Drug Hypersensitivity; Gonorrhea; Humans; Kanamycin; Leucomycins; Male; Neisseria gonorrhoeae; Penic | 1972 |
Managing the venereal diseases.
Topics: Ampicillin; Chancroid; Female; Gonorrhea; Humans; Lymphogranuloma Venereum; Male; Penicillin G Benza | 1972 |
A venereological panorama.
Topics: Candidiasis, Vulvovaginal; Drug Combinations; Drug Tolerance; Female; Gonorrhea; Homosexuality; Huma | 1972 |
The management of gonorrhoea and syphilis.
Topics: Female; Gonorrhea; Humans; Male; Penicillin G Benzathine; Penicillin G Procaine; Probenecid; Recurre | 1973 |
[New data on the therapy of gonorrhea].
Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Doxycycline; Gonorrhea; Humans; Penicillins; Probe | 1973 |
Intraocular treponemes.
Topics: Adult; Aged; Ampicillin; Aqueous Humor; Chorioretinitis; Eye Diseases; Female; Fluorescent Antibody | 1968 |
Diagnosis and treatment of venereal disease.
Topics: Adolescent; Adult; Ampicillin; Anti-Bacterial Agents; Erythromycin; False Positive Reactions; Female | 1971 |
Current therapy of gonorrhea.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Arthritis; Cervix Mucus; Female; Gonorrhea; Huma | 1971 |
Penicillins and aqueous humor.
Topics: Ampicillin; Animals; Aqueous Humor; Blood Chemical Analysis; Drug Synergism; Humans; Injections, Int | 1968 |