probenecid has been researched along with Seizures in 16 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The kynurenine pathway converts tryptophan into various compounds, including l-kynurenine, which in turn can be converted to the excitatory amino acid receptor antagonist kynurenic acid, which may therefore serve as a protective agent in such neurological disorders as epileptic seizures." | 7.72 | Kynurenine administered together with probenecid markedly inhibits pentylenetetrazol-induced seizures. An electrophysiological and behavioural study. ( Farkas, T; Janáky, T; Kis, Z; Marosi, M; Németh, H; Robotka, H; Rózsa, E; Somlai, C; Toldi, J; Vécsei, L, 2004) |
| "Kynurenine is a direct precursor of kynurenic acid, the only known endogenous antagonist of excitatory amino acid receptors in the brain." | 5.28 | Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain. ( Beal, MF; MacGarvey, U; Miller, J; Vécsei, L, 1992) |
| "The kynurenine pathway converts tryptophan into various compounds, including l-kynurenine, which in turn can be converted to the excitatory amino acid receptor antagonist kynurenic acid, which may therefore serve as a protective agent in such neurological disorders as epileptic seizures." | 3.72 | Kynurenine administered together with probenecid markedly inhibits pentylenetetrazol-induced seizures. An electrophysiological and behavioural study. ( Farkas, T; Janáky, T; Kis, Z; Marosi, M; Németh, H; Robotka, H; Rózsa, E; Somlai, C; Toldi, J; Vécsei, L, 2004) |
| " Coadministration of the transport inhibitor probenecid (p-(dipropylsulphamoyl)-benzoic acid) enhanced and prolonged the anticonvulsant action of NBQX and also enhanced and prolonged ataxia." | 3.68 | Probenecid pretreatment enhances anticonvulsant action of NBQX in mice. ( Taylor, CP; Vartanian, MG, 1992) |
| "Chronic administration of the same dose of cocaine to rhesus monkeys for up to 6 months was associated with progressive alterations in pathological behavior and increased susceptibility to seizures." | 3.65 | Progressive effects of cocaine on behavior and central amine metabolism in rhesus monkeys: relationship to kindling and psychosis. ( Black, KE; Kopanda, RT; Post, RM, 1976) |
| "Acute renal failure was induced by occlusion of bilateral renal arteries for 60 min, and the motor activity and brain monoamine turnover were examined 48 h later." | 1.31 | Uraemia suppresses central dopaminergic metabolism and impairs motor activity in rats. ( Adachi, N; Arai, T; Deshpande, G; Lei, B; Nagaro, T; Seyfried, FJ; Shimizu, I, 2001) |
| "Kynurenine is a direct precursor of kynurenic acid, the only known endogenous antagonist of excitatory amino acid receptors in the brain." | 1.28 | Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain. ( Beal, MF; MacGarvey, U; Miller, J; Vécsei, L, 1992) |
| "It is postulated that the seizures and neurological deterioration of the patient were related to a deficiency in the synthesis of biogenic amine neurotransmitters." | 1.26 | Biogenic amine synthesis defect in dihydropteridine reductase deficiency. ( Butler, IJ; Koslow, SH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (62.50) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dossi, E | 1 |
| Blauwblomme, T | 1 |
| Moulard, J | 1 |
| Chever, O | 1 |
| Vasile, F | 1 |
| Guinard, E | 1 |
| Le Bert, M | 1 |
| Couillin, I | 1 |
| Pallud, J | 1 |
| Capelle, L | 1 |
| Huberfeld, G | 1 |
| Rouach, N | 1 |
| Németh, H | 1 |
| Robotka, H | 1 |
| Kis, Z | 1 |
| Rózsa, E | 1 |
| Janáky, T | 1 |
| Somlai, C | 1 |
| Marosi, M | 1 |
| Farkas, T | 1 |
| Toldi, J | 1 |
| Vécsei, L | 2 |
| Smith, H | 1 |
| Lerner, PI | 1 |
| Weinstein, L | 1 |
| Lebrecht, U | 1 |
| Nowak, JZ | 1 |
| Akiyama, T | 1 |
| Sato, M | 1 |
| Otsuki, S | 1 |
| Galli, C | 1 |
| Spagnuolo, C | 1 |
| Petroni, A | 1 |
| Hesselink, MB | 1 |
| Smolders, H | 1 |
| Eilbacher, B | 1 |
| De Boer, AG | 1 |
| Breimer, DD | 1 |
| Danysz, W | 1 |
| Adachi, N | 1 |
| Lei, B | 1 |
| Deshpande, G | 1 |
| Seyfried, FJ | 1 |
| Shimizu, I | 1 |
| Nagaro, T | 1 |
| Arai, T | 1 |
| Koslow, SH | 1 |
| Butler, IJ | 1 |
| Brooks, BR | 1 |
| Wood, J | 1 |
| Sode, J | 1 |
| Engel, WK | 1 |
| Wallenstein, MC | 1 |
| Bito, LZ | 1 |
| Post, RM | 1 |
| Kopanda, RT | 1 |
| Black, KE | 1 |
| Taylor, CP | 1 |
| Vartanian, MG | 1 |
| Miller, J | 1 |
| MacGarvey, U | 1 |
| Beal, MF | 1 |
| Lehmann, A | 1 |
| Eickhoff, TC | 1 |
| Marks, MI | 1 |
16 other studies available for probenecid and Seizures
| Article | Year |
|---|---|
Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy.
Topics: Adenosine Triphosphate; Animals; Brain; Cerebral Cortex; Connexins; Disease Models, Animal; Epilepsy | 2018 |
Kynurenine administered together with probenecid markedly inhibits pentylenetetrazol-induced seizures. An electrophysiological and behavioural study.
Topics: Animals; Anticonvulsants; Behavior, Animal; Drug Synergism; Electrophysiology; Hippocampus; Kynureni | 2004 |
Neurotoxicity and "massive" intravenous therapy with penicillin. A study of possible predisposing factors.
Topics: Adolescent; Adult; Aged; Central Nervous System; Central Nervous System Diseases; Child; Child, Pres | 1967 |
Effect of single and repeated electroconvulsive shock on serotonergic system in rat brain--I. Metabolic studies.
Topics: Animals; Brain; Electroshock; Hydroxyindoleacetic Acid; Hypothalamus; Male; Probenecid; Rats; Seizur | 1980 |
[Probenecid-induced convulsion and cerebrospinal cyclic nucleotides in the kindling cat preparations (author's transl)].
Topics: Animals; Cats; Cyclic AMP; Cyclic GMP; Electric Stimulation; Electroencephalography; Kindling, Neuro | 1981 |
Factors affecting brain prostaglandin formation.
Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Convulsants; Fatty Acids, Essential; Gerbillinae; H | 1980 |
The role of probenecid-sensitive organic acid transport in the pharmacokinetics of N-methyl-D-aspartate receptor antagonists acting at the glycine(B)-site: microdialysis and maximum electroshock seizures studies.
Topics: Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; Drug Interactions; Electr | 1999 |
Uraemia suppresses central dopaminergic metabolism and impairs motor activity in rats.
Topics: Acute Kidney Injury; alpha-Methyltyrosine; Animals; Brain Chemistry; Coma; Confusion; Corpus Striatu | 2001 |
Biogenic amine synthesis defect in dihydropteridine reductase deficiency.
Topics: 5-Hydroxytryptophan; Biogenic Amines; Carbidopa; Dopamine; Homovanillic Acid; Humans; Hydroxyindolea | 1977 |
Cyclic nucleotide metabolism in neurological disease.
Topics: Cyclic AMP; Cyclic GMP; Humans; Nervous System Diseases; Probenecid; Seizures | 1976 |
Prostaglandin E1-induced alterations in visually-evoked response and production of epileptiform activity.
Topics: Acetaminophen; Animals; Bromcresol Green; Electroencephalography; Evoked Potentials; Female; Indomet | 1977 |
Progressive effects of cocaine on behavior and central amine metabolism in rhesus monkeys: relationship to kindling and psychosis.
Topics: Animals; Behavior, Animal; Catalepsy; Cocaine; Female; Haplorhini; Homovanillic Acid; Humans; Hydrox | 1976 |
Probenecid pretreatment enhances anticonvulsant action of NBQX in mice.
Topics: Animals; Anticonvulsants; Ataxia; Drug Synergism; Injections, Intravenous; Male; Mice; Motor Activit | 1992 |
Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain.
Topics: Analysis of Variance; Animals; Brain; Cerebral Cortex; Corpus Striatum; Diazepam; Dose-Response Rela | 1992 |
[Modification of the intensity of the audiogenic crisis by substances acting on the metabolism of biogenic amines in the mouse brain].
Topics: Animals; Brain Chemistry; Catecholamines; Cell Membrane Permeability; Methyltyrosines; Mice; Probene | 1968 |
Carbenicillin in therapy of systemic infections due to Pseudomonas.
Topics: Anti-Bacterial Agents; Benzene Derivatives; Humans; Injections, Intravenous; Leukemia; Penicillins; | 1970 |