probenecid has been researched along with Schizophrenia in 31 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors report cerebrospinal fluid (CSF) concentrations of five monoamine metabolites before and after probenecid administration in normal subjects and patients with depression and schizophrenia." | 3.66 | CSF monoamine metabolites in depression and schizophrenia. ( Anderson, PJ; Barchas, JD; Berger, PA; Davis, KL; Faull, KF; Kilkowski, J; Kraemer, H, 1980) |
| "Acetylcholinesterase (AChE) was measured in the cerebrospinal fluid (CSF) of patients with a diagnosis of Huntington's disease, depression, schizophrenia, or mania and also in the CSF of normal subjects." | 3.66 | Cerebrospinal fluid acetylcholinesterase in neuropsychiatric disorders. ( Berger, PA; Davis, KL; Hollister, LE; Livesey, J, 1979) |
| "The metabolites of serotonin, dopamine, and norepinephrine, 5-hydroxyindoleacetic acid (5HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxy-phenylethylene glycol (MHPG), respectively, were studied in cerebrospinal fluid of patients with acute schizophrenia." | 3.65 | Cerebrospinal fluid amine metabolites in acute schizophrenia. ( Carpenter, WT; Fink, E; Goodwin, FK; Post, RM, 1975) |
| "Thioridazine was administered to 14 patients diagnosed as within the "schizophrenic spectrum" with the result that substantial improvement in psychotic symptoms was achieved while significant extrapyramidal side effects occurred in only 1 patients." | 1.25 | Thioridazine: central dopamine turnover and clinical effects of antipsychotic drugs. ( Bowers, MB, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (96.77) | 18.7374 |
| 1990's | 1 (3.23) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, YF | 2 |
| Leckman, JF | 2 |
| Cohen, DJ | 1 |
| Shaywitz, BA | 1 |
| Caparulo, BK | 1 |
| Heninger, GR | 2 |
| Bowers, MB | 12 |
| Sturges, JS | 1 |
| Benson, KL | 1 |
| Zarcone, VP | 1 |
| Faull, KF | 3 |
| Barchas, JD | 2 |
| Berger, PA | 3 |
| Cowdry, RW | 1 |
| Ebert, MH | 1 |
| van Kammen, DP | 6 |
| Post, RM | 7 |
| Goodwin, FK | 6 |
| Sternberg, DE | 1 |
| Lake, CR | 1 |
| Ballenger, JC | 2 |
| Marder, SR | 1 |
| Bunney, WE | 2 |
| Kilkowski, J | 1 |
| Anderson, PJ | 1 |
| Kraemer, H | 1 |
| Davis, KL | 2 |
| Hollister, LE | 1 |
| Livesey, J | 1 |
| Moore, D | 1 |
| Tarsy, D | 1 |
| Study, RE | 1 |
| Karoum, F | 1 |
| Bunney, W | 1 |
| Gillin, JC | 1 |
| Jimerson, D | 1 |
| Van Kammen, D | 1 |
| Wyatt, RJ | 1 |
| Jimerson, DC | 2 |
| Carman, JS | 1 |
| Wood, JH | 1 |
| Lerner, P | 1 |
| Major, LF | 1 |
| Lovenberg, W | 1 |
| van Praag, HM | 1 |
| Smith, CC | 1 |
| Tallman, JF | 1 |
| Brown, GL | 1 |
| Fink, E | 1 |
| Carpenter, WT | 1 |
| Jibson, M | 1 |
| Csernansky, JG | 1 |
| Gerner, RH | 1 |
| Ninan, PT | 1 |
| Sjöström, R | 1 |
| Pind, K | 1 |
| Faurbye, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00004325] | 200 participants | Observational | 1988-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for probenecid and Schizophrenia
| Article | Year |
|---|---|
Cerebrospinal fluid probenecid studies: a reinterpretation.
Topics: Biological Transport; Brain; Depressive Disorder; Dopamine; Homovanillic Acid; Humans; Hydroxyindole | 1983 |
Studies of amine metabolites in affective illness and in schizophrenia: a comparative analysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain; Depressio | 1975 |
2 trials available for probenecid and Schizophrenia
| Article | Year |
|---|---|
Tardive dyskinesia: a clinical test of the supersensitivity hypothesis.
Topics: Adult; Aged; Clinical Trials as Topic; Cyclic AMP; Depression; Dyskinesia, Drug-Induced; Female; Hom | 1979 |
5-Hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines.
Topics: Clinical Trials as Topic; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Phenothiazines | 1973 |
27 other studies available for probenecid and Schizophrenia
| Article | Year |
|---|---|
[The probenecid test and its application to research in schizophrenia].
Topics: Biogenic Amines; Brain; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylgly | 1984 |
[Changes in the CSF levels of monoamine metabolites in 102 chronic schizophrenic patients following probenecid before and after neuroleptic medication].
Topics: Adult; Antipsychotic Agents; Biogenic Amines; Chronic Disease; Female; Homovanillic Acid; Humans; Hy | 1984 |
CSF monoamine metabolites in child and adult psychiatric patients. A developmental perspective.
Topics: Adolescent; Adult; Age Factors; Aged; Autistic Disorder; Bipolar Disorder; Child; Child, Preschool; | 1980 |
Relationship between estimated premorbid adjustment and CSF homovanillic acid and 5-hydroxyindoleacetic acid levels.
Topics: Adolescent; Adult; Affective Disorders, Psychotic; Aged; Female; Homovanillic Acid; Humans; Hydroxyi | 1981 |
REM sleep eye movement activity and CSF concentrations of 5-hydroxyindoleacetic acid in psychiatric patients.
Topics: Adult; Depressive Disorder; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Probenecid; Psychot | 1983 |
The effect of pimozide on CSF norepinephrine in schizophrenia.
Topics: Adolescent; Adult; Female; Humans; Male; Middle Aged; Norepinephrine; Pimozide; Probenecid; Psychoti | 1981 |
CSF monoamine metabolites in depression and schizophrenia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Mal | 1980 |
Cerebrospinal fluid acetylcholinesterase in neuropsychiatric disorders.
Topics: Acetylcholinesterase; Adult; Affective Symptoms; Choline; Circadian Rhythm; Humans; Huntington Disea | 1979 |
Cerebrospinal fluid cyclic AMP and acid monoamine metabolites following probenecid: studies in psychiatric patients.
Topics: Adolescent; Adult; Aged; Biogenic Amines; Chlorpromazine; Cyclic AMP; Depression; Female; Homovanill | 1979 |
Effect of probenecid on the concentration of the lumbar cerebrospinal fluid acidic metabolites of tyramine, octopamine, dopamine and norepinephrine.
Topics: Dopamine; Female; Gas Chromatography-Mass Spectrometry; Homovanillic Acid; Humans; Male; Norepinephr | 1977 |
CSF calcium: clinical correlates in affective illness and schizophrenia.
Topics: Bipolar Disorder; Calcium; Humans; Lithium; Magnesium; Premedication; Probenecid; Schizophrenia | 1979 |
Lithium: clinical effects and cerebrospinal fluid acid monoamine metabolites.
Topics: Adult; Affective Symptoms; Aged; Biogenic Amines; Bipolar Disorder; Depression; Electroencephalograp | 1977 |
Dopamine-beta-hydroxylase in the cerebrospinal fluid of psychiatric patients.
Topics: Adolescent; Adult; Aged; Alcoholism; Bipolar Disorder; Depression; Dopamine beta-Hydroxylase; Female | 1978 |
The significance of dopamine for the mode of action of neuroleptics and the pathogenesis of schizophrenia.
Topics: Dopamine; Homovanillic Acid; Humans; Probenecid; Schizophrenia; Tranquilizing Agents | 1977 |
An examination of baseline and drug-induced levels of cyclic nucleotides in the cerebrospinal fluid of control and psychiatric patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Bipolar Disorder; Depression; Humans; Imipramine; Lithium; M | 1976 |
CSF acid monoamine metabolities as a possible reflection of central MAO activity in chronic schizophrenia.
Topics: Acute Disease; Adolescent; Adult; Bipolar Disorder; Chronic Disease; Female; Homovanillic Acid; Huma | 1976 |
Thioridazine: central dopamine turnover and clinical effects of antipsychotic drugs.
Topics: Adolescent; Adult; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Midd | 1975 |
Cerebrospinal fluid amine metabolites in acute schizophrenia.
Topics: Acute Disease; Adolescent; Adult; Amines; Bipolar Disorder; Dopamine; Homovanillic Acid; Humans; Hyd | 1975 |
Cerebrospinal fluid amine metabolites in affective illness and schizophrenia: clinical and pharmacological studies.
Topics: Affective Symptoms; Amines; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Imipram | 1975 |
Intercorrelations among monoamine metabolite concentrations in human lumbar CSF are not due to a shared acid transport system.
Topics: Acid-Base Equilibrium; Administration, Oral; Blood-Brain Barrier; Depressive Disorder; Dose-Response | 1990 |
Cerebrospinal fluid cholecystokinin, bombesin and somatostatin in schizophrenia and normals.
Topics: Adolescent; Adult; Bombesin; Cholecystokinin; Female; Humans; Hydrocortisone; Male; Middle Aged; Pep | 1985 |
Steady-state levels of probenecid and their relation to acid monoamine metabolites in human cerebrospinal fluid.
Topics: Adult; Aged; Benzoates; Bipolar Disorder; Blood-Brain Barrier; Female; Humans; Huntington Disease; H | 1972 |
Concentration of homovanillic acid and 5-hydroxyindoleacetic acid in the cerebrospinal fluid after treatment with probenecid in patients with drug-induced tardive dyskinesia.
Topics: Dopamine; Humans; Hydroxyindoleacetic Acid; Movement Disorders; Phenylacetates; Probenecid; Schizoph | 1970 |
Fluorometric measurement of 5-hydroxyindoleacetic acid (5HIAA) and tryptophan in human CSF: effects of high doses of probenecid.
Topics: Administration, Oral; Adolescent; Adult; Bipolar Disorder; Brain Chemistry; Depression; Female; Fluo | 1974 |
Central dopamine turnover in schizophrenic syndromes.
Topics: Affective Symptoms; Chlorpromazine; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic | 1974 |
Clinical measurements of central dopamine and 5-hydroxytryptamine metabolism: reliability and interpretation of cerebrospinal fluid acid monoamine metabolite measures.
Topics: Age Factors; Central Nervous System; Chemistry, Clinical; Dopamine; Fluorometry; Humans; Hydroxyindo | 1972 |
Deficient transport mechanism for the removal of acid monoamine metabolites from cerebrospinal fluid.
Topics: Adult; Biological Transport, Active; Humans; Hydroxyindoleacetic Acid; Male; Phenylacetates; Probene | 1969 |