probenecid has been researched along with Reperfusion Injury in 4 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Probenecid has been used for decades to treat gout, and recent studies have revealed it is also a specific inhibitor of the pannexin-1 channel." | 5.42 | Probenecid protects against cerebral ischemia/reperfusion injury by inhibiting lysosomal and inflammatory damage in rats. ( Du, Y; He, F; Luo, B; Peng, G; Wang, J; Wei, R; Xu, Y; Yin, B, 2015) |
| "Probenecid has been used for decades to treat gout, and recent studies have revealed it is also a specific inhibitor of the pannexin-1 channel." | 1.42 | Probenecid protects against cerebral ischemia/reperfusion injury by inhibiting lysosomal and inflammatory damage in rats. ( Du, Y; He, F; Luo, B; Peng, G; Wang, J; Wei, R; Xu, Y; Yin, B, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| El-Maadawy, WH | 1 |
| Hassan, M | 1 |
| Badawy, MH | 1 |
| AbuSeada, A | 1 |
| Hafiz, E | 1 |
| Wei, R | 1 |
| Wang, J | 2 |
| Xu, Y | 1 |
| Yin, B | 1 |
| He, F | 1 |
| Du, Y | 1 |
| Peng, G | 1 |
| Luo, B | 1 |
| Jian, Z | 1 |
| Ding, S | 1 |
| Deng, H | 1 |
| Yi, W | 1 |
| Wang, L | 1 |
| Zhu, S | 1 |
| Gu, L | 1 |
| Xiong, X | 1 |
| Zhang, Y | 1 |
| Liu, GQ | 1 |
| Liu, XD | 1 |
| Xiao, XQ | 1 |
4 other studies available for probenecid and Reperfusion Injury
| Article | Year |
|---|---|
Probenecid induces the recovery of renal ischemia/reperfusion injury via the blockade of Pannexin 1/P2X7 receptor axis.
Topics: Adenosine Triphosphate; Animals; Caspase 1; Connexins; Cytokines; Forkhead Transcription Factors; In | 2022 |
Probenecid protects against cerebral ischemia/reperfusion injury by inhibiting lysosomal and inflammatory damage in rats.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Calcium-Binding Proteins; Calponins; Cathepsin B; | 2015 |
Probenecid protects against oxygen-glucose deprivation injury in primary astrocytes by regulating inflammasome activity.
Topics: Animals; Astrocytes; Brain Ischemia; Cell Survival; Connexins; Encephalitis; Glucose; Inflammasomes; | 2016 |
Efflux transport of [3H]GABA across blood-brain barrier after cerebral ischemia-reperfusion in rats.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; gamma-Aminobutyric Acid; Male; Microinjections; Proben | 1999 |