Page last updated: 2024-11-03

probenecid and Psychotic Disorders

probenecid has been researched along with Psychotic Disorders in 17 studies

Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.

Psychotic Disorders: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)

Research Excerpts

ExcerptRelevanceReference
"The probenecid technique was used in study of the central dopamine DA metabolism in patients with depressions, psychotic disorders, and Parkinson's disease."3.65Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders. ( Korf, J; Praag, HM; Schut, T, 1975)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-199016 (94.12)18.7374
1990's1 (5.88)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
MITCHELL, JH1
Bowers, MB7
Heninger, GR1
Sternberg, D1
Meltzer, HY1
Leckman, JF1
Sturges, JS1
Benson, KL1
Zarcone, VP1
Faull, KF2
Barchas, JD1
Berger, PA1
Korf, J2
van den Burg, W1
van den Hoofdakker, RH1
Cowdry, RW1
Ebert, MH1
van Kammen, DP2
Post, RM1
Goodwin, FK2
Gold, BI1
Roth, RH1
Sternberg, DE1
Lake, CR1
Ballenger, JC1
Marder, SR1
Bunney, WE1
Cohen, DJ2
Caparulo, BK1
Shaywitz, BA2
Praag, HM1
Schut, T1
Jibson, M1
Csernansky, JG1
Kupfer, DJ1
Foster, FG1
Bowers, M2
Johnson, WT1
Sack, RL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00004325]200 participants Observational1988-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for probenecid and Psychotic Disorders

ArticleYear
Cerebrospinal fluid probenecid studies: a reinterpretation.
    Biological psychiatry, 1983, Volume: 18, Issue:11

    Topics: Biological Transport; Brain; Depressive Disorder; Dopamine; Homovanillic Acid; Humans; Hydroxyindole

1983
Central dopamine function in affective illness: evidence from precursors, enzyme inhibitors, and studies of central dopamine turnover.
    Advances in biochemical psychopharmacology, 1974, Volume: 12, Issue:0

    Topics: Adult; Affective Symptoms; Anger; Bipolar Disorder; Central Nervous System; Depression; Diagnosis, D

1974

Trials

1 trial available for probenecid and Psychotic Disorders

ArticleYear
5-Hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines.
    Psychopharmacologia, 1973, Feb-20, Volume: 28, Issue:4

    Topics: Clinical Trials as Topic; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Phenothiazines

1973

Other Studies

14 other studies available for probenecid and Psychotic Disorders

ArticleYear
AMPICILLIN INTOLERANCE.
    British medical journal, 1965, Jan-23, Volume: 1, Issue:5429

    Topics: Ampicillin; Drug Tolerance; Enteritis; Penicillins; Probenecid; Psychoses, Substance-Induced; Psycho

1965
Clinical processes and central dopaminergic activity in psychotic disorders.
    Communications in psychopharmacology, 1980, Volume: 4, Issue:3

    Topics: Adolescent; Adult; Antipsychotic Agents; Dopamine; Female; gamma-Aminobutyric Acid; Homovanillic Aci

1980
Relationship between estimated premorbid adjustment and CSF homovanillic acid and 5-hydroxyindoleacetic acid levels.
    The American journal of psychiatry, 1981, Volume: 138, Issue:4

    Topics: Adolescent; Adult; Affective Disorders, Psychotic; Aged; Female; Homovanillic Acid; Humans; Hydroxyi

1981
REM sleep eye movement activity and CSF concentrations of 5-hydroxyindoleacetic acid in psychiatric patients.
    Psychiatry research, 1983, Volume: 8, Issue:1

    Topics: Adult; Depressive Disorder; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Probenecid; Psychot

1983
Acid metabolites and precursor amino acids of 5-hydroxytryptamine and dopamine in affective and other psychiatric disorders.
    Psychiatria clinica, 1983, Volume: 16, Issue:1

    Topics: Adjustment Disorders; Adult; Aged; Amino Acids; Bipolar Disorder; Depressive Disorder; Dopamine; Fem

1983
CSF GABA in psychotic disorders.
    Psychopharmacology, 1980, Volume: 70, Issue:3

    Topics: Adolescent; Adult; Female; gamma-Aminobutyric Acid; Haloperidol; Homovanillic Acid; Humans; Male; Mi

1980
The effect of pimozide on CSF norepinephrine in schizophrenia.
    The American journal of psychiatry, 1981, Volume: 138, Issue:8

    Topics: Adolescent; Adult; Female; Humans; Male; Middle Aged; Norepinephrine; Pimozide; Probenecid; Psychoti

1981
Dopamine and serotonin metabolism in neuropsychiatrically disturbed children. CSF homovanillic acid and 5-hydroxyindoleacetic acid.
    Archives of general psychiatry, 1977, Volume: 34, Issue:5

    Topics: Adolescent; Age Factors; Aphasia; Attention Deficit Disorder with Hyperactivity; Autistic Disorder;

1977
Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders.
    Psychological medicine, 1975, Volume: 5, Issue:2

    Topics: Adjustment Disorders; Bipolar Disorder; Brain; Carboxy-Lyases; Depression; Dihydroxyphenylalanine; D

1975
Serotonin (5HT) systems in psychotic states.
    Psychopharmacology communications, 1975, Volume: 1, Issue:6

    Topics: Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Probenecid; Psychotic Disorders; Serotonin; Tim

1975
Intercorrelations among monoamine metabolite concentrations in human lumbar CSF are not due to a shared acid transport system.
    Biological psychiatry, 1990, Oct-01, Volume: 28, Issue:7

    Topics: Acid-Base Equilibrium; Administration, Oral; Blood-Brain Barrier; Depressive Disorder; Dose-Response

1990
Selective suppression of REM sleep by probenecid.
    Brain research, 1972, Jun-08, Volume: 41, Issue:1

    Topics: Adult; Depression; Electroencephalography; Female; Humans; Male; Middle Aged; Neurotic Disorders; Pr

1972
Biogenic amines in autistic and atypical children. Cerebrospinal fluid measures of homovanillic acid and 5-hydroxyindoleacetic acid.
    Archives of general psychiatry, 1974, Volume: 31, Issue:6

    Topics: Autistic Disorder; Brain; Child; Child, Preschool; Diagnosis, Differential; Dopamine; Electroencepha

1974
Deficient transport mechanism for the removal of acid monoamine metabolites from cerebrospinal fluid.
    Brain research, 1969, Volume: 15, Issue:2

    Topics: Adult; Biological Transport, Active; Humans; Hydroxyindoleacetic Acid; Male; Phenylacetates; Probene

1969