probenecid has been researched along with Psychotic Disorders in 17 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Psychotic Disorders: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The probenecid technique was used in study of the central dopamine DA metabolism in patients with depressions, psychotic disorders, and Parkinson's disease." | 3.65 | Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders. ( Korf, J; Praag, HM; Schut, T, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (94.12) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MITCHELL, JH | 1 |
| Bowers, MB | 7 |
| Heninger, GR | 1 |
| Sternberg, D | 1 |
| Meltzer, HY | 1 |
| Leckman, JF | 1 |
| Sturges, JS | 1 |
| Benson, KL | 1 |
| Zarcone, VP | 1 |
| Faull, KF | 2 |
| Barchas, JD | 1 |
| Berger, PA | 1 |
| Korf, J | 2 |
| van den Burg, W | 1 |
| van den Hoofdakker, RH | 1 |
| Cowdry, RW | 1 |
| Ebert, MH | 1 |
| van Kammen, DP | 2 |
| Post, RM | 1 |
| Goodwin, FK | 2 |
| Gold, BI | 1 |
| Roth, RH | 1 |
| Sternberg, DE | 1 |
| Lake, CR | 1 |
| Ballenger, JC | 1 |
| Marder, SR | 1 |
| Bunney, WE | 1 |
| Cohen, DJ | 2 |
| Caparulo, BK | 1 |
| Shaywitz, BA | 2 |
| Praag, HM | 1 |
| Schut, T | 1 |
| Jibson, M | 1 |
| Csernansky, JG | 1 |
| Kupfer, DJ | 1 |
| Foster, FG | 1 |
| Bowers, M | 2 |
| Johnson, WT | 1 |
| Sack, RL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00004325] | 200 participants | Observational | 1988-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for probenecid and Psychotic Disorders
| Article | Year |
|---|---|
Cerebrospinal fluid probenecid studies: a reinterpretation.
Topics: Biological Transport; Brain; Depressive Disorder; Dopamine; Homovanillic Acid; Humans; Hydroxyindole | 1983 |
Central dopamine function in affective illness: evidence from precursors, enzyme inhibitors, and studies of central dopamine turnover.
Topics: Adult; Affective Symptoms; Anger; Bipolar Disorder; Central Nervous System; Depression; Diagnosis, D | 1974 |
1 trial available for probenecid and Psychotic Disorders
| Article | Year |
|---|---|
5-Hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines.
Topics: Clinical Trials as Topic; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Phenothiazines | 1973 |
14 other studies available for probenecid and Psychotic Disorders
| Article | Year |
|---|---|
AMPICILLIN INTOLERANCE.
Topics: Ampicillin; Drug Tolerance; Enteritis; Penicillins; Probenecid; Psychoses, Substance-Induced; Psycho | 1965 |
Clinical processes and central dopaminergic activity in psychotic disorders.
Topics: Adolescent; Adult; Antipsychotic Agents; Dopamine; Female; gamma-Aminobutyric Acid; Homovanillic Aci | 1980 |
Relationship between estimated premorbid adjustment and CSF homovanillic acid and 5-hydroxyindoleacetic acid levels.
Topics: Adolescent; Adult; Affective Disorders, Psychotic; Aged; Female; Homovanillic Acid; Humans; Hydroxyi | 1981 |
REM sleep eye movement activity and CSF concentrations of 5-hydroxyindoleacetic acid in psychiatric patients.
Topics: Adult; Depressive Disorder; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Probenecid; Psychot | 1983 |
Acid metabolites and precursor amino acids of 5-hydroxytryptamine and dopamine in affective and other psychiatric disorders.
Topics: Adjustment Disorders; Adult; Aged; Amino Acids; Bipolar Disorder; Depressive Disorder; Dopamine; Fem | 1983 |
CSF GABA in psychotic disorders.
Topics: Adolescent; Adult; Female; gamma-Aminobutyric Acid; Haloperidol; Homovanillic Acid; Humans; Male; Mi | 1980 |
The effect of pimozide on CSF norepinephrine in schizophrenia.
Topics: Adolescent; Adult; Female; Humans; Male; Middle Aged; Norepinephrine; Pimozide; Probenecid; Psychoti | 1981 |
Dopamine and serotonin metabolism in neuropsychiatrically disturbed children. CSF homovanillic acid and 5-hydroxyindoleacetic acid.
Topics: Adolescent; Age Factors; Aphasia; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; | 1977 |
Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders.
Topics: Adjustment Disorders; Bipolar Disorder; Brain; Carboxy-Lyases; Depression; Dihydroxyphenylalanine; D | 1975 |
Serotonin (5HT) systems in psychotic states.
Topics: Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Probenecid; Psychotic Disorders; Serotonin; Tim | 1975 |
Intercorrelations among monoamine metabolite concentrations in human lumbar CSF are not due to a shared acid transport system.
Topics: Acid-Base Equilibrium; Administration, Oral; Blood-Brain Barrier; Depressive Disorder; Dose-Response | 1990 |
Selective suppression of REM sleep by probenecid.
Topics: Adult; Depression; Electroencephalography; Female; Humans; Male; Middle Aged; Neurotic Disorders; Pr | 1972 |
Biogenic amines in autistic and atypical children. Cerebrospinal fluid measures of homovanillic acid and 5-hydroxyindoleacetic acid.
Topics: Autistic Disorder; Brain; Child; Child, Preschool; Diagnosis, Differential; Dopamine; Electroencepha | 1974 |
Deficient transport mechanism for the removal of acid monoamine metabolites from cerebrospinal fluid.
Topics: Adult; Biological Transport, Active; Humans; Hydroxyindoleacetic Acid; Male; Phenylacetates; Probene | 1969 |