probenecid has been researched along with Proteinuria in 9 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5 mg/kg with concomitant oral probenecid, saline prehydration, extended dosing intervals, and drug interruption for proteinuria (19 patients)." | 5.08 | (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine (cidofovir): results of a phase I/II study of a novel antiviral nucleotide analogue. ( Cundy, K; Drew, WL; Fisher, PE; Flaherty, J; Glutzer, E; Hannigan, J; James, C; Lalezari, JP; Martin, JC; Miner, D, 1995) |
| " Dose-dependent asymptomatic proteinuria (39%) and serum creatinine elevation (24%) were the most common adverse events thought to be related to cidofovir." | 2.69 | Randomized, controlled study of the safety and efficacy of intravenous cidofovir for the treatment of relapsing cytomegalovirus retinitis in patients with AIDS. ( Hardy, WD; Holland, GN; Ives, DV; Jaffe, HS; Johnson, M; Kemper, CA; Kramer, F; Kuppermann, BD; Lalezari, JP; Lewis, RA; McKinley, GF; Nelson, R; Northfelt, DW; Ruby, AE; Simon, GL; Stagg, RJ; Weinberg, DV; Wolitz, RA; Youle, M, 1998) |
| "Probenecid pretreatment promoted an elevation in the urinary 16-hr excretion of APAP and a diminution in the plasma levels attained by APAP." | 1.30 | Probenecid protects against In vivo acetaminophen-induced nephrotoxicity in male Wistar rats. ( Elías, MM; Monasterolo, LA; Trumper, L, 1998) |
| " Studies with [35S]-PAP-GSH at 40 mumol kg-1 showed selective retention of radioactivity in the kidney, relative to other organs 24 h after dosing and that some radioactivity was covalently bound to renal proteins." | 1.29 | Nephrotoxicity of 4-amino-3-S-glutathionylphenol and its modulation by metabolism or transport inhibitors. ( Foster, JR; Fowler, LM; Lock, EA, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Izzedine, H | 1 |
| Brocheriou, I | 1 |
| Becart, J | 1 |
| Deray, G | 1 |
| Lalezari, JP | 2 |
| Drew, WL | 1 |
| Glutzer, E | 1 |
| James, C | 1 |
| Miner, D | 1 |
| Flaherty, J | 1 |
| Fisher, PE | 1 |
| Cundy, K | 1 |
| Hannigan, J | 1 |
| Martin, JC | 1 |
| Fowler, LM | 1 |
| Foster, JR | 1 |
| Lock, EA | 1 |
| Trumper, L | 1 |
| Monasterolo, LA | 1 |
| Elías, MM | 1 |
| Holland, GN | 1 |
| Kramer, F | 1 |
| McKinley, GF | 1 |
| Kemper, CA | 1 |
| Ives, DV | 1 |
| Nelson, R | 1 |
| Hardy, WD | 1 |
| Kuppermann, BD | 1 |
| Northfelt, DW | 1 |
| Youle, M | 1 |
| Johnson, M | 1 |
| Lewis, RA | 1 |
| Weinberg, DV | 1 |
| Simon, GL | 1 |
| Wolitz, RA | 1 |
| Ruby, AE | 1 |
| Stagg, RJ | 1 |
| Jaffe, HS | 1 |
| Rankin, GO | 1 |
| Yang, DJ | 1 |
| Teets, VJ | 1 |
| Lo, HH | 1 |
| Brown, PI | 1 |
| Scott, JT | 1 |
| O'Brien, PK | 1 |
| Riccitelli, ML | 1 |
2 trials available for probenecid and Proteinuria
| Article | Year |
|---|---|
(S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine (cidofovir): results of a phase I/II study of a novel antiviral nucleotide analogue.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Cidofovir; Creatine; Cytomegalovirus | 1995 |
Randomized, controlled study of the safety and efficacy of intravenous cidofovir for the treatment of relapsing cytomegalovirus retinitis in patients with AIDS.
Topics: Adolescent; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Cidofovir; Creatinine; C | 1998 |
7 other studies available for probenecid and Proteinuria
| Article | Year |
|---|---|
Probenecid-induced membranous nephropathy.
Topics: Aged; Edema; Glomerulonephritis, Membranous; Gout; Humans; Male; Probenecid; Proteinuria; Uricosuric | 2007 |
Nephrotoxicity of 4-amino-3-S-glutathionylphenol and its modulation by metabolism or transport inhibitors.
Topics: Aminooxyacetic Acid; Animals; Ascorbic Acid; Blood Urea Nitrogen; gamma-Glutamyltransferase; Glutath | 1994 |
Probenecid protects against In vivo acetaminophen-induced nephrotoxicity in male Wistar rats.
Topics: Acetaminophen; Acute Disease; Animals; Biological Transport; Creatinine; Diuresis; Glomerular Filtra | 1998 |
The effect of probenecid on acute N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity in the Fischer 344 rat.
Topics: Animals; Blood Urea Nitrogen; Diuresis; Fungicides, Industrial; In Vitro Techniques; Kidney; Male; O | 1987 |
Probenecid, nephrotic syndrome, and renal failure.
Topics: Acute Kidney Injury; Aged; Edema; Gout; Humans; Male; Middle Aged; Nephrotic Syndrome; Probenecid; P | 1968 |
Probenecid and renal failure.
Topics: Acute Kidney Injury; Edema; Humans; Probenecid; Proteinuria | 1968 |
Etiology and treatment of gout--modern concepts.
Topics: Allopurinol; Colchicine; Crystallization; Diagnosis, Differential; Diet Therapy; Gout; Humans; Indom | 1968 |