probenecid has been researched along with Pregnancy in 52 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antifolate sulphadoxine-pyrimethamine (SP) has been used in the intermittent prevention of malaria in pregnancy (IPTp)." | 8.88 | Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy. ( Gutman, J; Kachur, SP; Mutabingwa, T; Nzila, A; Slutsker, L, 2012) |
| "The mechanism of transport of 5-methyltetrahydrofolate, the predominant form of folate in human blood, was investigated in JAR human placental choriocarcinoma cells." | 7.69 | Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells. ( Ganapathy, V; Leibach, FH; Mahesh, VB; Prasad, PD, 1994) |
| "The renal clearance of unconjugated oestriol, oestriol glucosiduronate and oestriol sulphate by the kidney in late human pregnancy has been compared with simultaneous measurements of inulin clearance." | 7.65 | The renal clearance of oestriol in late human pregnancy. ( Klopper, AI; Masson, GM; Swapp, GH, 1975) |
| "Ceftriaxone and spectinomycin are safe and effective for the treatment of gonorrhea in pregnancy." | 5.07 | Treatment of gonorrhea in pregnancy. ( Barnes, DL; Castaneda, YS; Cavenee, MR; Farris, JR; Spalding, TR; Wendel, GD, 1993) |
| "The antifolate sulphadoxine-pyrimethamine (SP) has been used in the intermittent prevention of malaria in pregnancy (IPTp)." | 4.88 | Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy. ( Gutman, J; Kachur, SP; Mutabingwa, T; Nzila, A; Slutsker, L, 2012) |
| "Probenecid has been used for decades in the treatment of gout but recently has also been found to improve outcomes in patients with heart failure via stimulation of the transient receptor potential vanilloid 2 (TRPV2) channel in cardiomyocytes." | 3.96 | Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy. ( Koch, SE; Kranias, EG; Liu, G; McDermott, MR; Onusko, E; Robbins, N; Rubinstein, J, 2020) |
| "The mechanism of transport of 5-methyltetrahydrofolate, the predominant form of folate in human blood, was investigated in JAR human placental choriocarcinoma cells." | 3.69 | Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells. ( Ganapathy, V; Leibach, FH; Mahesh, VB; Prasad, PD, 1994) |
| "The renal clearance of unconjugated oestriol, oestriol glucosiduronate and oestriol sulphate by the kidney in late human pregnancy has been compared with simultaneous measurements of inulin clearance." | 3.65 | The renal clearance of oestriol in late human pregnancy. ( Klopper, AI; Masson, GM; Swapp, GH, 1975) |
| "Recurrent pelvic inflammatory disease was associated with an almost 2-fold increase in infertility and more than 4-fold increase in CPP." | 2.76 | Recurrent PID, subsequent STI, and reproductive health outcomes: findings from the PID evaluation and clinical health (PEACH) study. ( Bass, D; Haggerty, C; Ness, RB; Trent, M, 2011) |
| "Epidemiological characteristics of preeclampsia such as its uniqueness to humans and an increased incidence of preeclampsia in multiple pregnancies, increased body mass index, renal and hypertensive disease all have uric acid as their common denominator." | 2.71 | Hyperuricaemia and preeclampsia: is there a pathogenic link? ( Schackis, RC, 2004) |
| "Childhood gonorrhea is most commonly manifested as vulvovaginitis in girls or urethritis in boys, usually without associated disseminated gonococcal infection." | 2.35 | Neonatal and childhood gonococcal infections. ( Brooks, GF; Israel, KS; Rissing, KB, 1975) |
| "Syphilis is a treatable condition, screening in pregnancy is both cost effective and cost beneficial." | 1.35 | Stroke in pregnancy associated with syphilis. ( Baker, PN; Bowring, J; Mahto, M; Mandal, D, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (57.69) | 18.7374 |
| 1990's | 8 (15.38) | 18.2507 |
| 2000's | 7 (13.46) | 29.6817 |
| 2010's | 5 (9.62) | 24.3611 |
| 2020's | 2 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Xiao, X | 1 |
| Tang, Y | 1 |
| Wooff, Y | 1 |
| Su, C | 1 |
| Kang, M | 1 |
| O'Carroll, SJ | 1 |
| Chen, Q | 1 |
| Chamley, L | 1 |
| Onusko, E | 1 |
| McDermott, MR | 1 |
| Robbins, N | 1 |
| Liu, G | 1 |
| Kranias, EG | 1 |
| Rubinstein, J | 1 |
| Koch, SE | 1 |
| Comunián-Carrasco, G | 1 |
| Peña-Martí, GE | 1 |
| Martí-Carvajal, AJ | 1 |
| Forrest, CM | 1 |
| McNair, K | 1 |
| Pisar, M | 1 |
| Khalil, OS | 1 |
| Darlington, LG | 1 |
| Stone, TW | 1 |
| Bowring, J | 1 |
| Mahto, M | 1 |
| Mandal, D | 1 |
| Baker, PN | 1 |
| Rahi, MM | 1 |
| Heikkinen, TM | 1 |
| Hakala, KE | 1 |
| Laine, KP | 1 |
| Biondi, C | 1 |
| Ferretti, ME | 1 |
| Lunghi, L | 1 |
| Medici, S | 1 |
| Cervellati, F | 1 |
| Pavan, B | 1 |
| Vesce, F | 1 |
| Morano, D | 1 |
| Adinolfi, E | 1 |
| Bertoni, F | 1 |
| Abelli, L | 1 |
| Trent, M | 1 |
| Bass, D | 1 |
| Ness, RB | 2 |
| Haggerty, C | 1 |
| Gutman, J | 1 |
| Kachur, SP | 1 |
| Slutsker, L | 1 |
| Nzila, A | 1 |
| Mutabingwa, T | 1 |
| Rillema, JA | 1 |
| Hill, MA | 1 |
| Haggerty, CL | 1 |
| Amortegui, A | 1 |
| Hendrix, SL | 1 |
| Hillier, SL | 1 |
| Holley, RL | 1 |
| Peipert, J | 1 |
| Randall, H | 1 |
| Sondheimer, SJ | 1 |
| Soper, DE | 1 |
| Sweet, RL | 1 |
| Trucco, G | 1 |
| HAYASHI, TT | 2 |
| CZACZKES, WJ | 1 |
| ULLMANN, TD | 1 |
| SADOWSKY, E | 1 |
| BATT, RE | 1 |
| CIRKSENA, WJ | 1 |
| LEBHERZ, TB | 1 |
| BROWN, CH | 1 |
| SAFFAN, BD | 1 |
| HOWARD, CM | 1 |
| PREEDY, JR | 1 |
| Hartmann, M | 1 |
| Schackis, RC | 1 |
| Leprohon, CE | 1 |
| Anderson, GH | 1 |
| Lutz, B | 1 |
| Shimizu, K | 1 |
| Stokes, JE | 1 |
| Evans, KE | 1 |
| Linton, CL | 1 |
| Gravett, PJ | 1 |
| Borthwick-Clarke, C | 1 |
| Henderson, GI | 1 |
| Perez, T | 1 |
| Schenker, S | 1 |
| Mackins, J | 1 |
| Antony, AC | 1 |
| Prasad, PD | 1 |
| Mahesh, VB | 1 |
| Leibach, FH | 1 |
| Ganapathy, V | 1 |
| Cavenee, MR | 1 |
| Farris, JR | 1 |
| Spalding, TR | 1 |
| Barnes, DL | 1 |
| Castaneda, YS | 1 |
| Wendel, GD | 1 |
| Kajiwara, Y | 1 |
| Yasutake, A | 1 |
| Adachi, T | 1 |
| Hirayama, K | 1 |
| Krunic, N | 2 |
| Adamson, SL | 2 |
| Bishai, I | 1 |
| Coceani, F | 2 |
| Walker, DW | 2 |
| Pratt, N | 1 |
| Curtis, B | 1 |
| Lacey, B | 1 |
| Nitsos, I | 1 |
| Brogden, RN | 1 |
| Heel, RC | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Henderson, R | 1 |
| St John, RK | 1 |
| Israel, KS | 1 |
| Rissing, KB | 1 |
| Brooks, GF | 1 |
| Talbott, JH | 1 |
| Gottlieb, N | 1 |
| Grendelmeier, P | 1 |
| Rodriguez, E | 1 |
| Swapp, GH | 1 |
| Masson, GM | 1 |
| Klopper, AI | 1 |
| Kaufman, A | 1 |
| Hilaski, S | 1 |
| DiVasto, P | 1 |
| VanderMeer, J | 1 |
| Eppler, B | 1 |
| Adelson, MD | 1 |
| Graves, WL | 1 |
| Osborne, NG | 1 |
| Varma, DR | 1 |
| Barrett-Connor, E | 1 |
| Fleming, WL | 1 |
| Mayr, E | 1 |
| Yard, AS | 1 |
| Juhasz, LP | 1 |
| Grimes, RM | 1 |
| Jablonski, P | 1 |
| Owen, JA | 1 |
| Malfatti, S | 1 |
| Pardini, C | 1 |
| Silvi, G | 1 |
| Nikolov, GS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative Effectiveness Clinical Early of Transvaginal and Laparoscopic Approaches for Drainage of Tubo -Ovarian Abscess. Randomized Noninferiority[NCT03166982] | 80 participants (Anticipated) | Interventional | 2016-10-26 | Recruiting | |||
| Study on the Displacement of Iodine Balance Value During Pregnancy and the Mechanism of Breast Iodine Homeostasis During Lactation Under Different Iodine Exposure[NCT05730803] | 1,200 participants (Anticipated) | Observational | 2023-02-17 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for probenecid and Pregnancy
| Article | Year |
|---|---|
Antibiotics for treating gonorrhoea in pregnancy.
Topics: Amoxicillin; Anti-Bacterial Agents; Cefixime; Ceftriaxone; Female; Gonorrhea; Humans; Pregnancy; Pre | 2018 |
Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy.
Topics: Antimalarials; Chemoprevention; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malari | 2012 |
Cefuroxime: a review of its antibacterial activity, pharmacological properties and therapeutic use.
Topics: Adult; Bacteria; Cephalosporins; Child; Drug Resistance, Microbial; Female; Furans; Gonorrhea; Human | 1979 |
Neonatal and childhood gonococcal infections.
Topics: Ampicillin; Arthritis; Child; Child, Preschool; Female; Gonorrhea; Humans; Infant; Infant, Newborn; | 1975 |
[Antarthritics. 41].
Topics: Acute Disease; Allopurinol; Antineoplastic Agents; Benzofurans; Colchicine; Female; Gout; Humans; Ph | 1969 |
5 trials available for probenecid and Pregnancy
| Article | Year |
|---|---|
Recurrent PID, subsequent STI, and reproductive health outcomes: findings from the PID evaluation and clinical health (PEACH) study.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Cefoxitin; Chronic Pain; Doxycycline; Female; Follow-Up St | 2011 |
Endometritis does not predict reproductive morbidity after pelvic inflammatory disease.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; Cefoxitin; Chla | 2003 |
Hyperuricaemia and preeclampsia: is there a pathogenic link?
Topics: Adult; Blood Pressure; Creatine; Female; Humans; Hyperuricemia; Platelet Count; Pre-Eclampsia; Pregn | 2004 |
Treatment of gonorrhea in pregnancy.
Topics: Adult; Amoxicillin; Ceftriaxone; Drug Therapy, Combination; Female; Gonorrhea; Humans; Pregnancy; Pr | 1993 |
Treatment of urinary infections in pregnancy using single versus 10-day dosing.
Topics: Ampicillin; Bacteriuria; Drug Therapy, Combination; Female; Humans; Pregnancy; Pregnancy Complicatio | 1992 |
42 other studies available for probenecid and Pregnancy
| Article | Year |
|---|---|
Upregulation of pannexin-1 hemichannels explains the apparent death of the syncytiotrophoblast during human placental explant culture.
Topics: Cell Death; Connexin 43; Connexins; Extracellular Vesicles; Female; Humans; Nerve Tissue Proteins; P | 2020 |
Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy.
Topics: Animals; Apoptosis; Calcium Channels; Cardiomyopathies; Disease Models, Animal; Echocardiography; Fe | 2020 |
Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine.
Topics: Adjuvants, Pharmaceutic; Animals; Doublecortin Domain Proteins; Doublecortin Protein; Female; Galant | 2015 |
Stroke in pregnancy associated with syphilis.
Topics: Adult; Anti-Bacterial Agents; Aspirin; Female; Gestational Age; Humans; Magnetic Resonance Imaging; | 2008 |
The effect of probenecid and MK-571 on the feto-maternal transfer of saquinavir in dually perfused human term placenta.
Topics: Antipyrine; Biological Transport; Female; HIV Protease Inhibitors; Humans; In Vitro Techniques; Mate | 2009 |
cAMP efflux from human trophoblast cell lines: a role for multidrug resistance protein (MRP)1 transporter.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cells, Cultured; Colforsi | 2010 |
Prolactin regulation of the pendrin-iodide transporter in the mammary gland.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Biological Transport; Blotting, Western; | 2003 |
The effect of benemid on uric acid excretion in normal pregnancy and in pre-eclampsia.
Topics: Biological Transport; Body Fluids; Female; Humans; Pre-Eclampsia; Pregnancy; Probenecid; Uric Acid | 1957 |
The effect of benemid on uric acid excretion in normal pregnancy and in pre-eclampsia.
Topics: Biological Transport; Body Fluids; Female; Humans; Pre-Eclampsia; Pregnancy; Probenecid; Uric Acid | 1957 |
The effect of benemid on uric acid excretion in normal pregnancy and in pre-eclampsia.
Topics: Biological Transport; Body Fluids; Female; Humans; Pre-Eclampsia; Pregnancy; Probenecid; Uric Acid | 1957 |
The effect of benemid on uric acid excretion in normal pregnancy and in pre-eclampsia.
Topics: Biological Transport; Body Fluids; Female; Humans; Pre-Eclampsia; Pregnancy; Probenecid; Uric Acid | 1957 |
Plasma uric acid levels, uric acid excretion, and response to probenecid in toxemia of pregnancy.
Topics: Biological Transport; Body Fluids; Female; Humans; Plasma; Pre-Eclampsia; Pregnancy; Probenecid; Uri | 1958 |
GOUT AND SALT-WASTING RENAL DISEASE DURING PREGNANCY; DIAGNOSIS, MANAGEMENT, AND FOLLOW-UP.
Topics: Blood Chemical Analysis; Colchicine; Diet Therapy; Diet, Sodium-Restricted; Female; Follow-Up Studie | 1963 |
THE RENAL CLEARANCE OF ENDOGENOUS ESTROGENS IN LATE PREGNANCY.
Topics: Adolescent; Biomedical Research; Blood Chemical Analysis; Body Fluids; Creatine; Creatinine; Estradi | 1964 |
[Therapy of syphilis].
Topics: Adult; Anti-Bacterial Agents; Azithromycin; Ceftriaxone; Controlled Clinical Trials as Topic; Doxycy | 2004 |
Relationships among maternal diet, serotonin metabolism at weaning, and protein selection of progeny.
Topics: Animals; Body Weight; Brain; Dietary Proteins; Feeding Behavior; Female; Hydroxyindoleacetic Acid; M | 1982 |
Gonococcal infections: new methods of treatment.
Topics: Anti-Bacterial Agents; Cephalosporins; Diagnosis, Differential; Drug Therapy, Combination; Female; G | 1982 |
Cefoperazone: absorption, excretion, distribution, and metabolism.
Topics: Adult; Animals; Ascitic Fluid; Bile; Cefoperazone; Cephalosporins; Dogs; Female; Haplorhini; Humans; | 1980 |
Incidence of asymptomatic gonorrhoea in antenatal patients, Auki, Solomon Islands.
Topics: Adolescent; Adult; Drug Therapy, Combination; Female; Gonorrhea; Humans; Male; Melanesia; Penicillin | 1982 |
The use of granulocyte transfusion: a case report.
Topics: Adult; Blood Transfusion; Choriocarcinoma; Female; Granulocytes; Humans; Methotrexate; Military Medi | 1980 |
Maternal-to-fetal transfer of 5-methyltetrahydrofolate by the perfused human placental cotyledon: evidence for a concentrative role by placental folate receptors in fetal folate delivery.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo | 1995 |
Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells.
Topics: Anti-Bacterial Agents; Base Sequence; Carrier Proteins; Choriocarcinoma; Female; Folate Receptors, G | 1994 |
Methylmercury transport across the placenta via neutral amino acid carrier.
Topics: Amino Acid Transport Systems; Animals; Carrier Proteins; Female; Fetal Blood; Injections, Intravenou | 1996 |
Prostaglandin uptake and catabolism by the choroid plexus during development in sheep.
Topics: Aging; Animals; Animals, Newborn; Biological Transport; Choroid Plexus; Dinoprost; Dinoprostone; Emb | 1997 |
Effect of probenecid on breathing movements and cerebral clearance of prostaglandin E2 in fetal sheep.
Topics: Anesthesia, General; Animals; Blood Gas Analysis; Blood Pressure; Brain Chemistry; Dinoprostone; Ele | 1998 |
Kynurenic acid in brain and cerebrospinal fluid of fetal, newborn, and adult sheep and effects of placental embolization.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Embolism; Female; Fetal Hypoxia; Fetus; Kynurenic | 1999 |
Differential uptake and catabolism of prostaglandin (PG)E(2) versus PGF(2alpha) in the sheep choroid plexus during development.
Topics: Adult; Aging; Animals; Biological Transport; Cerebral Ventricles; Choroid Plexus; Dinoprost; Dinopro | 2000 |
Gonorrhea: recommended treatment schedules.
Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Child; Female; Gonorrhea; Humans; Infant, Newborn; | 1975 |
Recommended treatment schedules for gonorrhea--1974.
Topics: Adolescent; Ampicillin; Anti-Bacterial Agents; Arthritis; Child; Child, Preschool; Coitus; Female; G | 1975 |
Gonorrhea: recommended treatment schedules--1974. Part I: Uncomplicated gonococcal infections in men and women; uncomplicated gonorrhea in pregnant patients; and acute salpingitis.
Topics: Acute Disease; Ampicillin; Coitus; Female; Gonorrhea; Humans; Male; Penicillin G Procaine; Pharyngea | 1975 |
Gonorrhea--recommended treatment schecules, 1974.
Topics: Adolescent; Ampicillin; Cephalosporins; Child; Child, Preschool; Drug Therapy, Combination; Erythrom | 1975 |
Gonorrhea. Recommended treatment schedules--1974.
Topics: Adolescent; Adult; Age Factors; Ampicillin; Anti-Bacterial Agents; Cefazolin; Child; Child, Preschoo | 1975 |
Recommended treatment schedules for gonorrhea--1979.
Topics: Acute Disease; Adult; Amoxicillin; Ampicillin; Child; Drug Administration Schedule; Epididymitis; Fe | 1979 |
Gonorrhea: recommended treatment schedules, 1974 Center for Disease Control.
Topics: Adolescent; Adult; Aminoglycosides; Anti-Bacterial Agents; Child; Child, Preschool; Drug Therapy, Co | 1975 |
Gouty arthritis in the black race.
Topics: Adult; Aged; Anemia, Sickle Cell; Arthritis; Benzothiadiazines; Black People; Colchicine; Diuretics; | 1975 |
The renal clearance of oestriol in late human pregnancy.
Topics: Aminohippuric Acids; Animals; Estriol; Female; Glomerular Filtration Rate; Glucuronates; Humans; Imm | 1975 |
Gonorrhea: recommended treatment schedules-1974. Part II: Disseminated gonococcal infection and gonococcal infection in pediatric patients.
Topics: Ampicillin; Anti-Bacterial Agents; Child; Child Abuse; Erythromycin; Female; Gonorrhea; Hospitalizat | 1975 |
Total health needs of the rape victim.
Topics: Abortion, Therapeutic; Adenocarcinoma; Adult; Affective Symptoms; Ampicillin; Diethylstilbestrol; Ec | 1975 |
Modification of transplacental distribution of salicylate in rats by acidosis and alkalosis.
Topics: Acidosis; Alkalosis; Ammonium Chloride; Animals; Bicarbonates; Blood Gas Analysis; Female; Hydrogen- | 1988 |
Gonorrhea.
Topics: Adolescent; Adult; Ampicillin; Diagnosis, Differential; Drug Therapy, Combination; Female; Gonorrhea | 1973 |
Managing the venereal diseases.
Topics: Ampicillin; Chancroid; Female; Gonorrhea; Humans; Lymphogranuloma Venereum; Male; Penicillin G Benza | 1972 |
Studies on the antifertility effect and metabolism of a new, postcoital oral contraceptive, 2-methyl-3-ethyl-4-phenyl-delta-4-cyclohexene carboxylic acid, sodium salt (ORF-4463).
Topics: Animals; Contraceptive Agents; Contraceptives, Oral; Copulation; Cyclohexanecarboxylic Acids; Fallop | 1969 |
The clinical chemistry of bromsulfophthalein and other cholephilic dyes.
Topics: Age Factors; Ampulla of Vater; Androgens; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bile; Bil | 1969 |
[Clinical trials of carbenicillin therapy in infections due to Pseudomonas aeruginosa].
Topics: Adult; Carbenicillin; Female; Gentamicins; Humans; Male; Mastitis; Middle Aged; Penicillins; Pregnan | 1971 |
[Podagric arthropathy].
Topics: Adolescent; Adult; Albuminuria; Algeria; Cardiovascular Diseases; Child; Child, Preschool; Cholester | 1971 |