probenecid has been researched along with Nervous System Diseases in 7 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the safety and efficacy of azithromycin, amoxicillin/probenecid, and doxycycline for the treatment of early Lyme disease, to identify risk factors for treatment failure, and to describe the serologic response in treated patients." | 5.07 | Treatment of early Lyme disease. ( Johnson, RC; Luger, SW; Massarotti, EM; Messner, RP; Rahn, DW; Steere, AC; Wong, JB, 1992) |
| "Maturation of monoamine neuronal systems was studied by measuring cerebrospinal fluid metabolites of dopamine (homovanillic acid) and serotonin (5-hydroxyindoleacetic acid) in 38 children with epilepsy and other neurological disorders, to whom probenecid had previously been administered." | 3.66 | Ontogeny of dopamine and serotonin metabolites in the cerebrospinal fluid of children with neurological disorders. ( Bowers, MB; Cohen, DJ; Leckman, JF; Shaywitz, BA; Young, JG, 1980) |
| "Probenecid (PROB) has been widely used for long time for different clinical purposes, from gout treatment to designs as a coadjutant for antibiotic agents." | 2.49 | Probenecid: an emerging tool for neuroprotection. ( Colín-González, AL; Santamaría, A, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Colín-González, AL | 1 |
| Santamaría, A | 1 |
| Shaywitz, BA | 1 |
| Cohen, DJ | 1 |
| Leckman, JF | 1 |
| Young, JG | 1 |
| Bowers, MB | 1 |
| Gagnieu, MC | 1 |
| Menouni-Foray, V | 1 |
| Guardiola, P | 1 |
| Quincy, C | 1 |
| Renaud, B | 1 |
| Brooks, BR | 1 |
| Wood, J | 1 |
| Sode, J | 1 |
| Engel, WK | 1 |
| Lake, CR | 2 |
| Wood, JH | 2 |
| Ziegler, MG | 2 |
| Ebert, MH | 1 |
| Kopin, IJ | 1 |
| Post, RM | 1 |
| Jimerson, DC | 1 |
| Bunney, WE | 1 |
| Goodwin, FK | 1 |
| Massarotti, EM | 1 |
| Luger, SW | 1 |
| Rahn, DW | 1 |
| Messner, RP | 1 |
| Wong, JB | 1 |
| Johnson, RC | 1 |
| Steere, AC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00004325] | 200 participants | Observational | 1988-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for probenecid and Nervous System Diseases
| Article | Year |
|---|---|
Probenecid: an emerging tool for neuroprotection.
Topics: Animals; Brain; Drug Interactions; Humans; Kynurenine; Models, Neurological; Nervous System Diseases | 2013 |
1 trial available for probenecid and Nervous System Diseases
| Article | Year |
|---|---|
Treatment of early Lyme disease.
Topics: Adult; Amoxicillin; Antibodies, Bacterial; Azithromycin; Borrelia burgdorferi Group; Doxycycline; Er | 1992 |
5 other studies available for probenecid and Nervous System Diseases
| Article | Year |
|---|---|
Ontogeny of dopamine and serotonin metabolites in the cerebrospinal fluid of children with neurological disorders.
Topics: Adolescent; Child; Child, Preschool; Dopamine; Epilepsy; Female; Homovanillic Acid; Humans; Hydroxyi | 1980 |
Liquid chromatographic determination of homovanillic acid, 5-hydroxyindoleacetic acid and probenecid levels in human cerebrospinal fluid during probenecid test.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Electrochemistry; Homovanillic Acid; Humans | 1984 |
Cyclic nucleotide metabolism in neurological disease.
Topics: Cyclic AMP; Cyclic GMP; Humans; Nervous System Diseases; Probenecid; Seizures | 1976 |
Probenecid-induced norepinephrine elevations in plasma and CSF.
Topics: Adolescent; Adult; Aged; Brain; Female; Humans; Male; Middle Aged; Nervous System Diseases; Norepine | 1978 |
Cerebrospinal fluid norepinephrine in affective illness.
Topics: Anxiety; Bipolar Disorder; Depression; Emotions; Female; Humans; Male; Motor Activity; Nervous Syste | 1978 |