probenecid has been researched along with Nerve Pain in 6 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neuropathic pain is still a challenge for clinical treatment as a result of the comprehensive pathogenesis." | 1.72 | Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses. ( Chen, G; Li, HY; Ling, ZM; Wang, Q; Wei, ZY, 2022) |
| "l-Kynurenine has antinociceptive effects in acute and inflammatory pain." | 1.39 | The L-kynurenine-probenecid combination reduces neuropathic pain in rats. ( Aguilera, P; Barragán-Iglesias, P; Bravo-Hernández, M; Cervantes-Durán, C; González-Esquivel, DF; Granados-Soto, V; Pérez-Severiano, F; Pineda-Farias, JB; Ríos, C, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 3 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crocetti, L | 2 |
| Guerrini, G | 2 |
| Puglioli, S | 1 |
| Giovannoni, MP | 2 |
| Di Cesare Mannelli, L | 2 |
| Lucarini, E | 2 |
| Ghelardini, C | 2 |
| Wang, J | 2 |
| Dahl, G | 2 |
| Melani, F | 1 |
| Lamanna, S | 1 |
| Wang, Q | 1 |
| Li, HY | 1 |
| Ling, ZM | 1 |
| Chen, G | 1 |
| Wei, ZY | 1 |
| Tachibana, M | 1 |
| Yamamura, N | 1 |
| Atiee, GJ | 1 |
| Hsu, C | 1 |
| Warren, V | 1 |
| He, L | 1 |
| Dishy, V | 1 |
| Zahir, H | 1 |
| Pineda-Farias, JB | 1 |
| Pérez-Severiano, F | 1 |
| González-Esquivel, DF | 1 |
| Barragán-Iglesias, P | 1 |
| Bravo-Hernández, M | 1 |
| Cervantes-Durán, C | 1 |
| Aguilera, P | 1 |
| Ríos, C | 1 |
| Granados-Soto, V | 1 |
| Bravo, D | 1 |
| Ibarra, P | 1 |
| Retamal, J | 1 |
| Pelissier, T | 1 |
| Laurido, C | 1 |
| Hernandez, A | 1 |
| Constandil, L | 1 |
1 trial available for probenecid and Nerve Pain
| Article | Year |
|---|---|
Coadministration of probenecid and cimetidine with mirogabalin in healthy subjects: A phase 1, randomized, open-label, drug-drug interaction study.
Topics: Administration, Oral; Adult; Area Under Curve; Bridged Bicyclo Compounds; Cimetidine; Cross-Over Stu | 2018 |
5 other studies available for probenecid and Nerve Pain
| Article | Year |
|---|---|
Design and synthesis of the first indole-based blockers of Panx-1 channel.
Topics: Animals; Binding Sites; Connexins; Disease Models, Animal; Drug Design; Humans; Indoles; Male; Membr | 2021 |
New Panx-1 Blockers: Synthesis, Biological Evaluation and Molecular Dynamic Studies.
Topics: Animals; Connexins; Indoles; Mice; Molecular Dynamics Simulation; Neuralgia; Probenecid | 2022 |
Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses.
Topics: Adenosine Triphosphate; Animals; Carbenoxolone; Connexins; Cytokines; Ethidium; Hyperalgesia; Lipopo | 2022 |
The L-kynurenine-probenecid combination reduces neuropathic pain in rats.
Topics: Animals; Drug Therapy, Combination; Female; Hyperalgesia; Kynurenine; Motor Activity; Neuralgia; Pai | 2013 |
Pannexin 1: a novel participant in neuropathic pain signaling in the rat spinal cord.
Topics: Animals; Carbenoxolone; Connexins; Hyperalgesia; Male; Nerve Tissue Proteins; Neuralgia; Pain Thresh | 2014 |