probenecid has been researched along with Nerve Degeneration in 7 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Animal models of Parkinson's disease have been widely used for investigating the mechanisms of neurodegenerative process and for discovering alternative strategies for treating the disease." | 1.35 | Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration. ( Kurz, MJ; Lau, YS; Pothakos, K, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, W | 1 |
| Hao, W | 1 |
| Meng, Z | 1 |
| Ding, S | 1 |
| Li, X | 1 |
| Zhang, T | 1 |
| Huang, W | 1 |
| Xu, L | 1 |
| Zhang, Y | 1 |
| Yang, J | 1 |
| Gu, X | 1 |
| Alvarez-Fischer, D | 1 |
| Guerreiro, S | 1 |
| Hunot, S | 1 |
| Saurini, F | 1 |
| Marien, M | 1 |
| Sokoloff, P | 1 |
| Hirsch, EC | 1 |
| Hartmann, A | 1 |
| Michel, PP | 1 |
| Pothakos, K | 2 |
| Kurz, MJ | 2 |
| Lau, YS | 3 |
| Xu, G | 1 |
| Xiong, Z | 1 |
| Yong, Y | 1 |
| Wang, Z | 1 |
| Ke, Z | 1 |
| Xia, Z | 1 |
| Hu, Y | 1 |
| Patki, G | 1 |
| Das-Panja, K | 1 |
| Le, WD | 1 |
| Ahmad, SO | 1 |
| Al-Jarrah, M | 1 |
| Novikova, L | 1 |
| Smirnova, IV | 1 |
| Stehno-Bittel, L | 1 |
| Chase, TN | 1 |
7 other studies available for probenecid and Nerve Degeneration
| Article | Year |
|---|---|
Molecular Regulatory Mechanism and Toxicology of Neurodegenerative Processes in MPTP/Probenecid-Induced Progressive Parkinson's Disease Mice Model Revealed by Transcriptome.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Disease Models, Animal; Gen | 2021 |
Modelling Parkinson-like neurodegeneration via osmotic minipump delivery of MPTP and probenecid.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adjuvants, Pharmaceutic; Animals; Brain; Chromatograph | 2008 |
Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Animals; Ataxia; Disease Models, Animal; | 2009 |
Catalpol attenuates MPTP induced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neurotrophic factor in striatum.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cells, Cultured; Chronic Disease; Corp | 2010 |
Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson's disease with moderate neurodegeneration.
Topics: Adjuvants, Pharmaceutic; Animals; Biomarkers; Brain-Derived Neurotrophic Factor; Corpus Striatum; Di | 2011 |
Endurance exercise promotes cardiorespiratory rehabilitation without neurorestoration in the chronic mouse model of parkinsonism with severe neurodegeneration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Calorimetry, Indirect; Citr | 2007 |
Serotonergic-dopaminergic interactions and extrapyramidal function.
Topics: Biogenic Amines; Brain; Dihydroxyphenylalanine; Dopamine; Extrapyramidal Tracts; Humans; Huntington | 1974 |