probenecid has been researched along with Nephrotic Syndrome in 6 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Nephrotic Syndrome: A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we evaluated the effects of PRB co-administered with mizoribine (MZR) on the pharmacokinetics (PK) of MZR in 12 patients with nephrotic syndrome." | 9.14 | Effects of probenecid on the pharmacokinetics of mizoribine and co-administration of the two drugs in patients with nephrotic syndrome. ( Hara, Y; Hashimoto, Y; Hosoya, T; Ito, H; Miyazaki, Y; Okonogi, H; Utsunomiya, Y, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Utsunomiya, Y | 1 |
| Hara, Y | 1 |
| Ito, H | 1 |
| Okonogi, H | 1 |
| Miyazaki, Y | 1 |
| Hashimoto, Y | 1 |
| Hosoya, T | 1 |
| FERRIS, TF | 1 |
| MORGAN, WS | 1 |
| LEVITIN, H | 1 |
| Sokol, A | 1 |
| Bashner, MH | 1 |
| Okun, R | 1 |
| Bergan, T | 1 |
| Westlie, L | 1 |
| Brodwall, EK | 1 |
| Hertz, P | 1 |
| Yager, H | 1 |
| Richardson, JA | 1 |
| Scott, JT | 1 |
| O'Brien, PK | 1 |
1 trial available for probenecid and Nephrotic Syndrome
| Article | Year |
|---|---|
Effects of probenecid on the pharmacokinetics of mizoribine and co-administration of the two drugs in patients with nephrotic syndrome.
Topics: Adult; Aged; Female; Half-Life; Humans; Immunosuppressive Agents; Male; Middle Aged; Nephrotic Syndr | 2010 |
5 other studies available for probenecid and Nephrotic Syndrome
| Article | Year |
|---|---|
Nephrotic syndrome caused by probenecid.
Topics: Gout; Humans; Nephrotic Syndrome; Probenecid | 1961 |
Nephrotic syndrome caused by probenecid.
Topics: Humans; Male; Nephrotic Syndrome; Probenecid | 1967 |
Influence of probenecid on gentamycin pharmacokinetics.
Topics: Adolescent; Adult; Biological Transport; Creatinine; Female; Gentamicins; Glomerular Filtration Rate | 1972 |
Probenecid-induced nephrotic syndrome.
Topics: Antigen-Antibody Reactions; Basement Membrane; Biopsy; Epithelial Cells; Gout; Humans; Kidney; Kidne | 1972 |
Probenecid, nephrotic syndrome, and renal failure.
Topics: Acute Kidney Injury; Aged; Edema; Gout; Humans; Male; Middle Aged; Nephrotic Syndrome; Probenecid; P | 1968 |