probenecid has been researched along with Meningitis in 7 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Meningitis: Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-three infants and children with bacterial meningitis were treated intravenously with 200 mg of amoxicillin sodium per kg per day for 10 days." | 9.04 | Clinicopharmacological evaluation of amoxicillin and probenecid against bacterial meningitis. ( Craft, JC; Feldman, WE; Nelson, JD, 1979) |
| "The concentrations of cefoxitin in serum and cerebrospinal fluid (CSF) were measured simultaneously in three groups of patients, 12 with aseptic meningitis (group 1) and 17 and 14 with bacterial meningitis (groups 2 and 3)." | 7.66 | Cefoxitin concentrations in the cerebrospinal fluids of patients with meningitis. ( Cherubin, C; Humbert, G; Leroy, A; Rogez, JP, 1980) |
| "Forty-three infants and children with bacterial meningitis were treated intravenously with 200 mg of amoxicillin sodium per kg per day for 10 days." | 5.04 | Clinicopharmacological evaluation of amoxicillin and probenecid against bacterial meningitis. ( Craft, JC; Feldman, WE; Nelson, JD, 1979) |
| "The concentrations of cefoxitin in serum and cerebrospinal fluid (CSF) were measured simultaneously in three groups of patients, 12 with aseptic meningitis (group 1) and 17 and 14 with bacterial meningitis (groups 2 and 3)." | 3.66 | Cefoxitin concentrations in the cerebrospinal fluids of patients with meningitis. ( Cherubin, C; Humbert, G; Leroy, A; Rogez, JP, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shann, F | 1 |
| Germer, S | 1 |
| Humbert, G | 1 |
| Leroy, A | 1 |
| Rogez, JP | 1 |
| Cherubin, C | 1 |
| Sande, MA | 1 |
| Sherertz, RJ | 1 |
| Zak, O | 1 |
| Dacey, RG | 1 |
| Bodine, JA | 1 |
| Strausbaugh, LJ | 1 |
| Craft, JC | 1 |
| Feldman, WE | 1 |
| Nelson, JD | 1 |
| Spector, R | 1 |
| Lorenzo, AV | 1 |
| Knudsen, ET | 1 |
1 trial available for probenecid and Meningitis
| Article | Year |
|---|---|
Clinicopharmacological evaluation of amoxicillin and probenecid against bacterial meningitis.
Topics: Amoxicillin; Ampicillin; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; | 1979 |
6 other studies available for probenecid and Meningitis
| Article | Year |
|---|---|
Treatment of bacterial meningitis in children without intravenous fluids.
Topics: Administration, Oral; Anti-Bacterial Agents; Chloramphenicol; Humans; Infant; Injections, Intramuscu | 1981 |
Cefoxitin concentrations in the cerebrospinal fluids of patients with meningitis.
Topics: Adolescent; Adult; Age Factors; Aged; Bacterial Infections; Blood Urea Nitrogen; Cefoxitin; Humans; | 1980 |
Factors influencing the penetration of antimicrobial agents into the cerebrospinal fluid of experimental animals.
Topics: Animals; Cephalosporins; Disease Models, Animal; Meningitis; Penicillins; Probenecid; Protein Bindin | 1978 |
Gonorrhea: recommended treatment schedules, 1974 Center for Disease Control.
Topics: Adolescent; Adult; Aminoglycosides; Anti-Bacterial Agents; Child; Child, Preschool; Drug Therapy, Co | 1975 |
Inhibition of penicillin transport from the cerebrospinal fluid after intracisternal inoculation of bacteria.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Cerebrospinal Fluid; Choroid Plexus; Cisterna M | 1974 |
[Factors, affecting penicillin therapy].
Topics: Ampicillin; Anti-Bacterial Agents; Antineoplastic Agents; Bronchitis; Carbenicillin; Cloxacillin; Do | 1971 |