probenecid has been researched along with Meningitis, Pneumococcal in 2 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Meningitis, Pneumococcal: An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study examined the effects of experimental pneumococcal meningitis and probenecid administration on the penetration of parenterally administered vancomycin into cerebrospinal fluid in rabbits." | 3.66 | Effect of meningitis and probenecid on the penetration of vancomycin into cerebrospinal fluid in rabbits. ( Krontz, DP; Strausbaugh, LJ, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krontz, DP | 1 |
| Strausbaugh, LJ | 1 |
| Dacey, RG | 1 |
| Sande, MA | 1 |
2 other studies available for probenecid and Meningitis, Pneumococcal
| Article | Year |
|---|---|
Effect of meningitis and probenecid on the penetration of vancomycin into cerebrospinal fluid in rabbits.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Meningitis, Pneumococcal; Probenecid; Rabbits; V | 1980 |
Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives.
Topics: Animals; Cephalosporins; Drug Synergism; Meningitis, Pneumococcal; Penicillins; Probenecid; Rabbits; | 1974 |