probenecid has been researched along with Melanoma in 2 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human malignant melanoma is characterised by unresponsiveness to conventional chemotherapy." | 1.30 | Possible role of the multidrug resistance-associated protein (MRP) in chemoresistance of human melanoma cells. ( Berger, W; Elbling, L; Hauptmann, E; Kokoschka, EM; Micksche, M; Vetterlein, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berger, W | 1 |
| Hauptmann, E | 1 |
| Elbling, L | 1 |
| Vetterlein, M | 1 |
| Kokoschka, EM | 1 |
| Micksche, M | 1 |
| Molinari, A | 1 |
| Calcabrini, A | 1 |
| Meschini, S | 1 |
| Stringaro, A | 1 |
| Del Bufalo, D | 1 |
| Cianfriglia, M | 1 |
| Arancia, G | 1 |
2 other studies available for probenecid and Melanoma
| Article | Year |
|---|---|
Possible role of the multidrug resistance-associated protein (MRP) in chemoresistance of human melanoma cells.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP-Binding Cass | 1997 |
Detection of P-glycoprotein in the Golgi apparatus of drug-untreated human melanoma cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Compartmentation | 1998 |