probenecid has been researched along with Malaria, Falciparum in 5 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antifolate sulphadoxine-pyrimethamine (SP) has been used in the intermittent prevention of malaria in pregnancy (IPTp)." | 8.88 | Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy. ( Gutman, J; Kachur, SP; Mutabingwa, T; Nzila, A; Slutsker, L, 2012) |
| "The antifolate sulphadoxine-pyrimethamine (SP) has been used in the intermittent prevention of malaria in pregnancy (IPTp)." | 4.88 | Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy. ( Gutman, J; Kachur, SP; Mutabingwa, T; Nzila, A; Slutsker, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gutman, J | 1 |
| Kachur, SP | 1 |
| Slutsker, L | 1 |
| Nzila, A | 1 |
| Mutabingwa, T | 1 |
| Sowunmi, A | 2 |
| Fehintola, FA | 2 |
| Adedeji, AA | 2 |
| Gbotosho, GO | 1 |
| Falade, CO | 1 |
| Tambo, E | 1 |
| Fateye, BA | 2 |
| Happi, TC | 1 |
| Oduola, AM | 1 |
| Nzila, AM | 1 |
| Kokwaro, G | 1 |
| Winstanley, PA | 1 |
| Marsh, K | 1 |
| Ward, SA | 1 |
| Tahar, R | 1 |
| Basco, LK | 1 |
2 reviews available for probenecid and Malaria, Falciparum
| Article | Year |
|---|---|
Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy.
Topics: Antimalarials; Chemoprevention; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malari | 2012 |
Therapeutic potential of folate uptake inhibition in Plasmodium falciparum.
Topics: Animals; Antimalarials; Drug Combinations; Drug Resistance; Drug Synergism; Drug Therapy, Combinatio | 2004 |
1 trial available for probenecid and Malaria, Falciparum
| Article | Year |
|---|---|
Open randomized study of pyrimethamine-sulphadoxine vs. pyrimethamine-sulphadoxine plus probenecid for the treatment of uncomplicated Plasmodium falciparum malaria in children.
Topics: Acute Disease; Antimalarials; Child; Child, Preschool; Drug Combinations; Drug Interactions; Drug Re | 2004 |
2 other studies available for probenecid and Malaria, Falciparum
| Article | Year |
|---|---|
Comparative effects of pyrimethamine-sulfadoxine, with and without probenecid, on Plasmodium falciparum gametocytes in children with acute, uncomplicated malaria.
Topics: Acute Disease; Animals; Antimalarials; Child; Drug Combinations; Drug Therapy, Combination; Endemic | 2004 |
Molecular epidemiology of malaria in Cameroon. XXVI. Twelve-year in vitro and molecular surveillance of pyrimethamine resistance and experimental studies to modulate pyrimethamine resistance.
Topics: Adolescent; Animals; Antimalarials; Cameroon; DNA, Protozoan; Drug Resistance; Drug Therapy, Combina | 2007 |