probenecid has been researched along with MPTP Neurotoxicity Syndrome in 10 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin is a natural antioxidant and free radical scavenger that has been shown to effectively reduce cellular oxidative stress and protect mitochondrial functions in vitro." | 1.37 | Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson's disease. ( Lau, YS; Patki, G, 2011) |
| "Animal models of Parkinson's disease have been widely used for investigating the mechanisms of neurodegenerative process and for discovering alternative strategies for treating the disease." | 1.35 | Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration. ( Kurz, MJ; Lau, YS; Pothakos, K, 2009) |
| "Three common dosing regimens of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model of Parkinson's disease (PD) were compared in C57BL/6 mice on behavior, striatal and extra-striatal neurotransmission, and brain cytokines, to clarify the differences between regimens on these variables." | 1.35 | Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease. ( Luchtman, DW; Shao, D; Song, C, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, W | 1 |
| Hao, W | 1 |
| Meng, Z | 1 |
| Ding, S | 1 |
| Li, X | 1 |
| Zhang, T | 1 |
| Huang, W | 1 |
| Xu, L | 1 |
| Zhang, Y | 1 |
| Yang, J | 1 |
| Gu, X | 1 |
| Ferguson, SA | 1 |
| Law, CD | 1 |
| Sarkar, S | 1 |
| Janakiraman, U | 1 |
| Manivasagam, T | 3 |
| Thenmozhi, AJ | 1 |
| Essa, MM | 3 |
| Barathidasan, R | 1 |
| SaravanaBabu, C | 1 |
| Guillemin, GJ | 1 |
| Khan, MA | 1 |
| Nataraj, J | 1 |
| Justin Thenmozhi, A | 1 |
| Pothakos, K | 1 |
| Kurz, MJ | 1 |
| Lau, YS | 3 |
| Luchtman, DW | 2 |
| Shao, D | 1 |
| Song, C | 2 |
| Patki, G | 2 |
| Meng, Q | 1 |
| Anandhan, A | 1 |
10 other studies available for probenecid and MPTP Neurotoxicity Syndrome
| Article | Year |
|---|---|
Molecular Regulatory Mechanism and Toxicology of Neurodegenerative Processes in MPTP/Probenecid-Induced Progressive Parkinson's Disease Mice Model Revealed by Transcriptome.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Disease Models, Animal; Gen | 2021 |
Chronic MPTP treatment produces hyperactivity in male mice which is not alleviated by concurrent trehalose treatment.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Disease Models, Animal; Hyp | 2015 |
Influences of Chronic Mild Stress Exposure on Motor, Non-Motor Impairments and Neurochemical Variables in Specific Brain Areas of MPTP/Probenecid Induced Neurotoxicity in Mice.
Topics: alpha-Synuclein; Animals; Behavior, Animal; Brain; Dopamine; Locomotion; Male; Mice; Mice, Inbred C5 | 2016 |
Neurotrophic Effect of Asiatic acid, a Triterpene of Centella asiatica Against Chronic 1-Methyl 4-Phenyl 1, 2, 3, 6-Tetrahydropyridine Hydrochloride/Probenecid Mouse Model of Parkinson's disease: The Role of MAPK, PI3K-Akt-GSK3β and mTOR Signalling Pathwa
Topics: Animals; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein | 2017 |
Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Animals; Ataxia; Disease Models, Animal; | 2009 |
Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Brain Chemistry; Chromatography, High Pressure Liquid; Cytokines; Inflamm | 2009 |
Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson's disease.
Topics: Adenosine Triphosphate; Animals; Antiparkinson Agents; Behavior, Animal; Corpus Striatum; Free Radic | 2011 |
Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson's disease.
Topics: Animals; Biogenic Monoamines; Brain; Cyclooxygenase 2; Cytokines; Eicosapentaenoic Acid; Exploratory | 2012 |
Impact of exercise on mitochondrial transcription factor expression and damage in the striatum of a chronic mouse model of Parkinson's disease.
Topics: Adjuvants, Pharmaceutic; Analysis of Variance; Animals; Chronic Disease; Corpus Striatum; Cytochrome | 2011 |
Therapeutic attenuation of neuroinflammation and apoptosis by black tea theaflavin in chronic MPTP/probenecid model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants; Apoptosis; bcl-2-Associated X P | 2013 |