probenecid has been researched along with Leukemia L 1210 in 12 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since IAHQ has only modest activity against L1210 leukemia in mice, it was tested in combination with methotrexate (MTX), probenecid, or verapamil in an effort to enhance efficacy." | 1.27 | Effects of 5,8-dideazaisopteroylglutamate (IAHQ) on L1210 leukemia in mice when given alone and in combination with methotrexate, probenecid, or verapamil. ( Gale, GR; Hynes, JB; Smith, AB, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (50.00) | 18.7374 |
| 1990's | 6 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gangji, D | 1 |
| Ross, WE | 1 |
| Bleyer, WA | 1 |
| Poplack, DG | 1 |
| Glaubiger, DL | 1 |
| Sirotnak, FM | 3 |
| Moccio, DM | 2 |
| Hancock, CH | 1 |
| Young, CW | 2 |
| Sierra, EE | 2 |
| Brigle, KE | 2 |
| Spinella, MJ | 2 |
| Goldman, ID | 2 |
| Henderson, GB | 5 |
| Hughes, TR | 1 |
| O'Leary, DF | 1 |
| Tsuji, JM | 2 |
| Hynes, JB | 1 |
| Smith, AB | 1 |
| Gale, GR | 1 |
| Kumar, HP | 1 |
| Zevely, EM | 1 |
12 other studies available for probenecid and Leukemia L 1210
| Article | Year |
|---|---|
Probenecid inhibition of methotrexate cytotoxicity in mouse L1210 leukemia cells.
Topics: Animals; Cell Survival; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Drug Interacti | 1984 |
Improved methotrexate therapy of murine tumors obtained by probenecid-mediated pharmacological modulation at the level of membrane transport.
Topics: Animals; Biological Transport, Active; Bone Marrow; Female; Kidney; Kinetics; Leukemia L1210; Liver; | 1981 |
Increased accumulation of methotrexate by murine tumor cells in vitro in the presence of probenecid which is mediated by a preferential inhibition of efflux.
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Leukemia L1210; Methotrexate; Mice; Neoplas | 1981 |
Comparison of transport properties of the reduced folate carrier and folate receptor in murine L1210 leukemia cells.
Topics: Animals; Biological Transport; Carrier Proteins; Folate Receptors, GPI-Anchored; Hydrogen-Ion Concen | 1995 |
Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells.
Topics: Alkenes; Animals; Biological Transport; Carrier Proteins; Energy Metabolism; Folate Receptors, GPI-A | 1995 |
Altered expression of unidirectional extrusion routes for methotrexate and cholate in an efflux variant of L1210 cells.
Topics: Animals; Cell Division; Cholic Acids; Drug Interactions; Drug Tolerance; Exocytosis; Leukemia L1210; | 1993 |
Separation and inhibitor specificity of a second unidirectional efflux route for methotrexate in L1210 cells.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Le | 1992 |
The issues of transport multiplicity and energetics pertaining to methotrexate efflux in L1210 cells addressed by an analysis of cis and trans effects of inhibitors.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Energy Metabolism; Leukemia L1210; Methotrexa | 1991 |
Identification of cholate as a shared substrate for the unidirectional efflux systems for methotrexate in L1210 mouse cells.
Topics: Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cholic Acids; Cytochalasin | 1990 |
Effects of 5,8-dideazaisopteroylglutamate (IAHQ) on L1210 leukemia in mice when given alone and in combination with methotrexate, probenecid, or verapamil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Folic Acid Antagonists; Leukemia L1210; Mal | 1986 |
Characterization of the individual transport routes that mediate the influx and efflux of methotrexate in CCRF-CEM human lymphoblastic cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; | 1986 |
Inhibitory effects of probenecid on the individual transport routes which mediate the influx and efflux of methotrexate in L1210 cells.
Topics: Animals; Biological Transport; Cells, Cultured; Energy Metabolism; Leukemia L1210; Methotrexate; Mic | 1985 |