probenecid has been researched along with Kidney Tubular Necrosis, Acute in 6 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Kidney Tubular Necrosis, Acute: Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with probenecid prevented increased plasma creatinine and tubulointerstitial injuries, and reduced both the extent and the severity of ultrastructural lesions induced by aristolochic acid, such as the loss of brush border, mitochondrial edema, and the disappearance of mitochondrial crests." | 1.38 | Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy. ( Antoine, MH; Arlt, VM; Baudoux, TE; De Prez, EG; Goujon, JM; Nortier, JL; Pozdzik, AA; Quellard, N, 2012) |
| "Probenecid pretreatment did not decrease the toxicity of BH4." | 1.27 | The toxicity of tetrahydrobiopterin: acute and subchronic studies in mice. ( Combs, AB; Folkers, K; Lewandowski, EM, 1986) |
| "Phenacetin pretreatment (597 mg/kg) was less effective, while paracetamol (503 mg/kg) was without effect in this regard." | 1.26 | Studies on the modification of renal lesions due to aspirin and oxyphenbutazone in the rat and the effects on the kidney of 2:4 dinitrophenol. ( Arnold, L; Collins, C; Starmer, GA, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baudoux, TE | 1 |
| Pozdzik, AA | 1 |
| Arlt, VM | 1 |
| De Prez, EG | 1 |
| Antoine, MH | 1 |
| Quellard, N | 1 |
| Goujon, JM | 1 |
| Nortier, JL | 1 |
| Arnold, L | 1 |
| Collins, C | 1 |
| Starmer, GA | 1 |
| Tune, BM | 1 |
| Hill, BA | 1 |
| Monks, TJ | 1 |
| Lau, SS | 1 |
| Lewandowski, EM | 1 |
| Combs, AB | 1 |
| Folkers, K | 1 |
| Elfarra, AA | 1 |
| Baggs, RB | 1 |
| Anders, MW | 1 |
6 other studies available for probenecid and Kidney Tubular Necrosis, Acute
| Article | Year |
|---|---|
Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy.
Topics: Animals; Aristolochic Acids; Atrophy; Biomarkers; Cell Proliferation; Cell Survival; Creatinine; Cyt | 2012 |
Studies on the modification of renal lesions due to aspirin and oxyphenbutazone in the rat and the effects on the kidney of 2:4 dinitrophenol.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Aspirin; Dinitrophenols; Female; Kidney Tubular Necrosi | 1976 |
Relationship between the transport and toxicity of cephalosporins in the kidney.
Topics: Acute Kidney Injury; Aminohippuric Acids; Animals; Animals, Newborn; Biological Transport; Cefazolin | 1975 |
The effects of 2,3,5-(triglutathion-S-yl)hydroquinone on renal mitochondrial respiratory function in vivo and in vitro: possible role in cytotoxicity.
Topics: Animals; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Glutathione; Hydroquinones; Ki | 1992 |
The toxicity of tetrahydrobiopterin: acute and subchronic studies in mice.
Topics: Administration, Oral; Animals; Biopterins; Body Weight; Female; Injections, Intraperitoneal; Kidney | 1986 |
Structure-nephrotoxicity relationships of S-(2-chloroethyl)-DL-cysteine and analogs: role for an episulfonium ion.
Topics: Acute Kidney Injury; Alanine Transaminase; Animals; Blood Urea Nitrogen; Cysteine; Glycosuria; Ions; | 1985 |