probenecid has been researched along with Kidney Failure, Chronic in 14 studies
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Probenecid has been shown to decrease renal and biliary excretion of organic acids." | 2.67 | Lack of probenecid effect on nonrenal excretion of ceftriaxone in anephric patients. ( Audet, PR; Carbone, JJ; Gibson, GA; Morrison, G; Patel, IH; Soni, PP, 1990) |
| " The mean serum half-life in normals was 1." | 1.25 | Pharmacodynamics of cefazolin in the presence of normal and impaired renal function. ( Rein, MF; Sande, MA; Westervelt, FB, 1973) |
| "Cephalexin IG was given by intravenous injection to eight normal volunteers, five patients with chronic renal failure, and three patients during a period of haemodialysis." | 1.25 | Clinical pharmacology of cephalexin administered by intravenous injection. ( Davies, JA; Holt, JM, 1972) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (50.00) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jhawar, S | 1 |
| Singh, P | 1 |
| Torres, D | 1 |
| Ramirez-Valle, F | 1 |
| Kassem, H | 1 |
| Banerjee, T | 1 |
| Dolgalev, I | 1 |
| Heguy, A | 1 |
| Zavadil, J | 1 |
| Lowenstein, J | 1 |
| Fujita, T | 1 |
| Ishihara, K | 1 |
| Yasuda, S | 1 |
| Nakamura, T | 1 |
| Maeda, M | 1 |
| Kobayashi, M | 1 |
| Sahashi, K | 1 |
| Ikeda, Y | 1 |
| Kumagai, Y | 1 |
| Majima, M | 1 |
| Araya, CE | 1 |
| Lew, JF | 1 |
| Fennell, RS | 1 |
| Neiberger, RE | 1 |
| Dharnidharka, VR | 1 |
| Hisatome, I | 1 |
| Kosaka, H | 1 |
| Ohtahara, K | 1 |
| Tsuboi, M | 1 |
| Manabe, I | 1 |
| Ohtahara, A | 1 |
| Sawaguchi, M | 1 |
| Igawa, O | 1 |
| Tanaka, Y | 1 |
| Fujimoto, Y | 1 |
| Yoshida, A | 1 |
| Takeda, A | 1 |
| Shigemasa, C | 1 |
| Lhotta, K | 1 |
| Gruber, J | 1 |
| Sgonc, R | 1 |
| Fend, F | 1 |
| König, P | 1 |
| Deguchi, T | 1 |
| Ohtsuki, S | 1 |
| Otagiri, M | 1 |
| Takanaga, H | 1 |
| Asaba, H | 1 |
| Mori, S | 1 |
| Terasaki, T | 1 |
| Patel, IH | 1 |
| Soni, PP | 1 |
| Carbone, JJ | 1 |
| Audet, PR | 1 |
| Morrison, G | 1 |
| Gibson, GA | 1 |
| Garyfallos, A | 1 |
| Magoula, I | 1 |
| Tsapas, G | 1 |
| Barza, M | 1 |
| Weinstein, L | 1 |
| Danovitch, GM | 1 |
| Grantham, JJ | 1 |
| Irwin, RL | 1 |
| Qualizza, PB | 1 |
| Tucker, DR | 1 |
| Whittier, FC | 1 |
| Rein, MF | 1 |
| Westervelt, FB | 1 |
| Sande, MA | 1 |
| Davies, JA | 1 |
| Holt, JM | 1 |
| Sjöberg, KH | 1 |
1 review available for probenecid and Kidney Failure, Chronic
| Article | Year |
|---|---|
Uric acid transport in renal failure. A review.
Topics: Absorption; Biological Transport; Depression, Chemical; Homeostasis; Humans; Kidney; Kidney Failure, | 1972 |
1 trial available for probenecid and Kidney Failure, Chronic
| Article | Year |
|---|---|
Lack of probenecid effect on nonrenal excretion of ceftriaxone in anephric patients.
Topics: Adult; Ceftriaxone; Chromatography, High Pressure Liquid; Humans; Kidney Failure, Chronic; Middle Ag | 1990 |
12 other studies available for probenecid and Kidney Failure, Chronic
| Article | Year |
|---|---|
Functional genomic analysis identifies indoxyl sulfate as a major, poorly dialyzable uremic toxin in end-stage renal disease.
Topics: Adult; Aged; Animals; Cell Line; Chromatography, High Pressure Liquid; Culture Media; Female; Gene E | 2015 |
In vivo kinetics of indoxyl sulfate in humans and its renal interaction with angiotensin-converting enzyme inhibitor quinapril in rats.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Animals; Area Under Curve; Chromatography, High Pre | 2012 |
Intermediate-dose cidofovir without probenecid in the treatment of BK virus allograft nephropathy.
Topics: Adult; Antiviral Agents; Biopsy; BK Virus; Child; Cidofovir; Contraindications; Cytosine; DNA, Viral | 2006 |
Renal handling of urate in a patient with familial juvenile gouty nephropathy.
Topics: Adolescent; Benzbromarone; Female; Genes, Dominant; Gout; Gout Suppressants; Humans; Kidney; Kidney | 1996 |
Apoptosis of tubular epithelial cells in familial juvenile gouty nephropathy.
Topics: Adult; Apoptosis; Benzbromarone; Biopsy; Biotin; Deoxyuracil Nucleotides; DNA Fragmentation; Family | 1998 |
Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.
Topics: Animals; Anions; Biological Transport; Dose-Response Relationship, Drug; Female; Furans; Indican; Ki | 2002 |
Evaluation of the renal mechanisms for urate homeostasis in uremic patients by probenecid and pyrazinamide test.
Topics: Absorption; Creatinine; Female; Glomerular Filtration Rate; Gout; Homeostasis; Humans; Kidney Failur | 1987 |
Some determinants of the distribution of penicillins and cephalosporins in the body. Practical and theoretical considerations.
Topics: Albumins; Binding Sites; Biopharmaceutics; Blood Proteins; Capillary Permeability; Cephalosporins; H | 1974 |
Fluid secretion in isolated proximal straight renal tubules. Effect of human uremic serum.
Topics: Acetates; Aminohippuric Acids; Animals; Benzoates; Blood Urea Nitrogen; Creatinine; Female; Guanidin | 1973 |
Pharmacodynamics of cefazolin in the presence of normal and impaired renal function.
Topics: Cephalosporins; Creatinine; Drug Interactions; Half-Life; Humans; Kidney Failure, Chronic; Kidney Fu | 1973 |
Clinical pharmacology of cephalexin administered by intravenous injection.
Topics: Adult; Cephalexin; Cephalosporins; Female; Half-Life; Humans; Injections, Intravenous; Kidney Failur | 1972 |
Allopurinol therapy of gout with renal complications.
Topics: Adult; Allopurinol; Calcium; Creatine; Enzyme Therapy; Gout; Humans; Kidney Failure, Chronic; Male; | 1966 |