Page last updated: 2024-11-03

probenecid and Intellectual Disability

probenecid has been researched along with Intellectual Disability in 4 studies

Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.

Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)

Research Excerpts

ExcerptRelevanceReference
"It is postulated that the seizures and neurological deterioration of the patient were related to a deficiency in the synthesis of biogenic amine neurotransmitters."1.26Biogenic amine synthesis defect in dihydropteridine reductase deficiency. ( Butler, IJ; Koslow, SH, 1977)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19904 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Michener, WM1
Koslow, SH1
Butler, IJ1
Airaksinen, EM1
Kauko, K1
Manzke, H1
Harms, D1
Dörner, K1

Other Studies

4 other studies available for probenecid and Intellectual Disability

ArticleYear
Hyperuricemia and mental retardation with athetosis and self-mutilation.
    American journal of diseases of children (1960), 1967, Volume: 113, Issue:2

    Topics: Allopurinol; Athetosis; Body Height; Body Weight; Child; Child, Preschool; Chorea; Humans; Infant; I

1967
Biogenic amine synthesis defect in dihydropteridine reductase deficiency.
    Science (New York, N.Y.), 1977, Nov-04, Volume: 198, Issue:4316

    Topics: 5-Hydroxytryptophan; Biogenic Amines; Carbidopa; Dopamine; Homovanillic Acid; Humans; Hydroxyindolea

1977
Effect of probenecid on 5-hydroxyindoles in cerebrospinal fluid in Down's syndrome.
    Annals of clinical research, 1973, Volume: 5, Issue:6

    Topics: Administration, Oral; Adolescent; Child; Chromatography, Gel; Depression, Chemical; Down Syndrome; F

1973
[Treatment of congenital hyperuricemia].
    Monatsschrift fur Kinderheilkunde, 1971, Volume: 119, Issue:7

    Topics: Adolescent; Allopurinol; Athetosis; Child; Humans; Hypoxanthines; Intellectual Disability; Lesch-Nyh

1971